CRCGN014_HEPG2_24H:B11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4'-(chloroacetyl)acetanilide 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN014_HEPG2_24H:B11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.63587
ZNF589 zinc finger protein 589 4.29727
CHN1 chimerin 1 3.99668
TBPL1 TBP-like 1 3.77834
HDGFL3 HDGF like 3 3.41803
PNKP polynucleotide kinase 3'-phosphatase 3.10781
GSTZ1 glutathione S-transferase zeta 1 2.75735
GPATCH8 G patch domain containing 8 2.57748
BACE2 beta-site APP-cleaving enzyme 2 2.56114
MSRA methionine sulfoxide reductase A 2.52632
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.49902
NOTCH1 notch 1 2.45325
MCOLN1 mucolipin 1 2.40462
BZW2 basic leucine zipper and W2 domains 2 2.34549
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.33273
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 2.30892
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.18161
BPHL biphenyl hydrolase-like (serine hydrolase) 2.06713
MCM3 minichromosome maintenance complex component 3 2.05543
MLH1 mutL homolog 1 2.00798

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -5.301
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.68773
ZMIZ1 zinc finger, MIZ-type containing 1 -4.60725
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.54513
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.33275
YME1L1 YME1-like 1 ATPase -4.0754
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -4.00716
HMG20B high mobility group 20B -3.94109
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.80306
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.69572
RGS2 regulator of G-protein signaling 2 -3.47628
FGFR4 fibroblast growth factor receptor 4 -3.04866
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.90792
ADI1 acireductone dioxygenase 1 -2.77837
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.73234
TRIB3 tribbles pseudokinase 3 -2.61743
PCNA proliferating cell nuclear antigen -2.56712
CD320 CD320 molecule -2.50831
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.36844
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -2.2905
EGF epidermal growth factor -2.24907
MAPK13 mitogen-activated protein kinase 13 -2.24188
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.20348
TOR1A torsin family 1, member A (torsin A) -2.20244
EPHA7 EPH receptor A7 -2.07933
CRISP3 cysteine-rich secretory protein 3 -2.07202
LIN37 lin-37 DREAM MuvB core complex component -2.06775
TES testin LIM domain protein -2.01751