CRCGN014_HEPG2_24H:B13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-anisidine.hcl 39.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

79 genes differentially expressed following the CRCGN014_HEPG2_24H:B13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 7.47319
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.54465
CCNF cyclin F 4.73173
MAP7 microtubule-associated protein 7 4.6063
E2F2 E2F transcription factor 2 4.39788
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.17852
UBQLN2 ubiquilin 2 4.11704
PNKP polynucleotide kinase 3'-phosphatase 4.11614
TATDN2 TatD DNase domain containing 2 3.92158
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.72854
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.69231
GATA3 GATA binding protein 3 3.48248
PEX11A peroxisomal biogenesis factor 11 alpha 3.22982
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.22054
DENND2D DENN/MADD domain containing 2D 3.1949
JADE2 jade family PHD finger 2 3.11419
BPHL biphenyl hydrolase-like (serine hydrolase) 2.87723
LYN LYN proto-oncogene, Src family tyrosine kinase 2.86941
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.83338
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.80764
PRR15L proline rich 15-like 2.69213
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.67353
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.66287
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 2.60441
RXYLT1 ribitol xylosyltransferase 1 2.54267
PLEKHA6 pleckstrin homology domain containing, family A member 6 2.52336
CENPS-CORT CENPS-CORT readthrough 2.48934
FIRRM FIGNL1 interacting regulator of recombination and mitosis 2.47723
STIMATE STIM activating enhancer 2.39342
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.36639
DYNLT3 dynein, light chain, Tctex-type 3 2.25487
TBX3 T-box 3 2.21459
MVD mevalonate (diphospho) decarboxylase 2.21455
PTCD2 pentatricopeptide repeat domain 2 2.17103
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.16866
EPN2 epsin 2 2.15115
BLM Bloom syndrome, RecQ helicase-like 2.13748
CXCL2 chemokine (C-X-C motif) ligand 2 2.07458
ANAPC1 anaphase promoting complex subunit 1 2.05483
USO1 USO1 vesicle transport factor 2.02799
PCID2 PCI domain containing 2 2.02455
KLHL12 kelch-like family member 12 2.01536
DDHD2 DDHD domain containing 2 2.01502

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
DSG2 desmoglein 2 -4.89621
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.75886
VAT1 vesicle amine transport 1 -4.38895
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.35924
GDF15 growth differentiation factor 15 -4.30939
THAP11 THAP domain containing 11 -4.29801
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.28592
MRPS2 mitochondrial ribosomal protein S2 -4.27525
KDM3A lysine (K)-specific demethylase 3A -4.27337
PCCB propionyl CoA carboxylase, beta polypeptide -4.25886
PCNA proliferating cell nuclear antigen -4.24116
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.10042
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.78418
CCDC86 coiled-coil domain containing 86 -3.60821
TRIB3 tribbles pseudokinase 3 -3.42439
SCAND1 SCAN domain containing 1 -2.99657
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.94619
CHMP4B charged multivesicular body protein 4B -2.85195
ZMIZ1 zinc finger, MIZ-type containing 1 -2.71347
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.52191
GNAS GNAS complex locus -2.50778
TCERG1 transcription elongation regulator 1 -2.44301
CDC20 cell division cycle 20 -2.38217
AP1S1 adaptor-related protein complex 1, sigma 1 subunit -2.3306
CCNB2 cyclin B2 -2.2332
PRPF4 pre-mRNA processing factor 4 -2.2278
MRPL9 mitochondrial ribosomal protein L9 -2.19547
CTDNEP1 CTD nuclear envelope phosphatase 1 -2.17226
MNT MAX network transcriptional repressor -2.1412
ADRM1 adhesion regulating molecule 1 -2.07931
VEGFB vascular endothelial growth factor B -2.07261
SLC35F2 solute carrier family 35, member F2 -2.05244
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.04748
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 -2.01132
FMNL1 formin-like 1 -2.00513