| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | phenformin 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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160 genes differentially expressed following the CRCGN014_HEPG2_24H:B14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CNPY3 | canopy FGF signaling regulator 3 | 6.43395 |
| KIFBP | kinesin family binding protein | 6.23814 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 6.22726 |
| INPP1 | inositol polyphosphate-1-phosphatase | 5.95383 |
| PNKP | polynucleotide kinase 3'-phosphatase | 5.06707 |
| TRIB3 | tribbles pseudokinase 3 | 4.69633 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 4.32415 |
| MVP | major vault protein | 3.90579 |
| VAT1 | vesicle amine transport 1 | 3.71772 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 3.55132 |
| STX1A | syntaxin 1A (brain) | 3.52842 |
| ACOT9 | acyl-CoA thioesterase 9 | 3.39578 |
| MSRA | methionine sulfoxide reductase A | 3.34263 |
| RAB21 | RAB21, member RAS oncogene family | 3.33316 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 3.22661 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 3.21882 |
| ZFP36 | ZFP36 ring finger protein | 3.21452 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 3.18234 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 3.13514 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 3.03599 |
| DNM1 | dynamin 1 | 2.99455 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.93155 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 2.89452 |
| CDC45 | cell division cycle 45 | 2.8198 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 2.75531 |
| SQOR | sulfide quinone oxidoreductase | 2.75305 |
| MED15 | mediator complex subunit 15 | 2.72779 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.70265 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 2.68467 |
| SQSTM1 | sequestosome 1 | 2.66085 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | 2.60026 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 2.59451 |
| IER3 | immediate early response 3 | 2.58252 |
| MAP7 | microtubule-associated protein 7 | 2.56459 |
| DUSP6 | dual specificity phosphatase 6 | 2.55757 |
| TRIB1 | tribbles pseudokinase 1 | 2.54745 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.53428 |
| EVL | Enah/Vasp-like | 2.51315 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 2.51241 |
| SLC35F2 | solute carrier family 35, member F2 | 2.50825 |
| IL4R | interleukin 4 receptor | 2.48431 |
| AARS1 | alanyl-tRNA synthetase 1 | 2.46966 |
| BLVRA | biliverdin reductase A | 2.42536 |
| GLRX | glutaredoxin (thioltransferase) | 2.39761 |
| FOSL1 | FOS-like antigen 1 | 2.39733 |
| GTF2E2 | general transcription factor IIE, polypeptide 2, beta 34kDa | 2.3956 |
| FHOD1 | formin homology 2 domain containing 1 | 2.38974 |
| CYCS | cytochrome c, somatic | 2.38359 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.37819 |
| EGR1 | early growth response 1 | 2.36023 |
| SFTPB | surfactant protein B | 2.34776 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 2.34756 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.33051 |
| RAP1GAP | RAP1 GTPase activating protein | 2.32404 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 2.31133 |
| MBNL2 | muscleblind-like splicing regulator 2 | 2.29747 |
| GARS1 | glycyl-tRNA synthetase 1 | 2.29713 |
| STAP2 | signal transducing adaptor family member 2 | 2.26213 |
| TXNRD1 | thioredoxin reductase 1 | 2.26066 |
| ACTN4 | actinin, alpha 4 | 2.25149 |
| GTPBP2 | GTP binding protein 2 | 2.25019 |
| LGALS8 | lectin, galactoside-binding, soluble, 8 | 2.14599 |
| PPRC1 | peroxisome proliferator-activated receptor gamma, coactivator-related 1 | 2.13871 |
| ZBTB35 | zinc finger and BTB domain containing 35 | 2.13329 |
| GRB10 | growth factor receptor-bound protein 10 | 2.12885 |
| JAM3 | junctional adhesion molecule 3 | 2.12863 |
| PIP4K2B | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | 2.11653 |
| YIPF3 | Yip1 domain family, member 3 | 2.11085 |
| SFXN3 | sideroflexin 3 | 2.1055 |
| AGTPBP1 | ATP/GTP binding protein 1 | 2.10286 |
| POLR3E | polymerase (RNA) III (DNA directed) polypeptide E (80kD) | 2.10123 |
| SARS1 | seryl-tRNA synthetase 1 | 2.0964 |
| ST18 | suppression of tumorigenicity 18, zinc finger | 2.09241 |
| COLGALT2 | collagen beta(1-O)galactosyltransferase 2 | 2.0907 |
| PLS1 | plastin 1 | 2.08952 |
| PLA1A | phospholipase A1 member A | 2.07382 |
| MGAT4A | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A | 2.07078 |
| MICU1 | mitochondrial calcium uptake 1 | 2.01627 |
| ITGB5 | integrin, beta 5 | 2.00891 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 2.00591 |
| NANOS3 | nanos homolog 3 (Drosophila) | 2.00565 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ISOC1 | isochorismatase domain containing 1 | -7.35575 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -5.72769 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -5.33375 |
| TCTN1 | tectonic family member 1 | -5.3261 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -5.0264 |
| CCNB1 | cyclin B1 | -4.62066 |
| MELK | maternal embryonic leucine zipper kinase | -4.58061 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -4.48544 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -4.20149 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -4.091 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -4.04746 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -3.80506 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -3.7079 |
| LDHD | lactate dehydrogenase D | -3.66428 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.64234 |
| AURKB | aurora kinase B | -3.59408 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -3.58003 |
| CDK1 | cyclin-dependent kinase 1 | -3.5316 |
| ZW10 | zw10 kinetochore protein | -3.4377 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -3.24045 |
| TLR4 | toll-like receptor 4 | -3.22351 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -3.18978 |
| CCNA2 | cyclin A2 | -3.13496 |
| TWF2 | twinfilin actin binding protein 2 | -3.11268 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -3.10798 |
| PLK1 | polo-like kinase 1 | -3.06209 |
| ICAM3 | intercellular adhesion molecule 3 | -2.91571 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.85147 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -2.84071 |
| WASHC4 | WASH complex subunit 4 | -2.83765 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -2.82466 |
| POLR1A | polymerase (RNA) I polypeptide A, 194kDa | -2.80252 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -2.77684 |
| CDC20 | cell division cycle 20 | -2.75157 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.71974 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.71791 |
| HAT1 | histone acetyltransferase 1 | -2.68308 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -2.5525 |
| TMEM97 | transmembrane protein 97 | -2.53003 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | -2.52053 |
| KIF11 | kinesin family member 11 | -2.50455 |
| PGAM4 | phosphoglycerate mutase family member 4 | -2.46432 |
| KIFC1 | kinesin family member C1 | -2.43044 |
| LBR | lamin B receptor | -2.3997 |
| ERCC6L | excision repair cross-complementation group 6-like | -2.3892 |
| DBF4 | DBF4 zinc finger | -2.38903 |
| ZNHIT1 | zinc finger, HIT-type containing 1 | -2.37906 |
| TMCO1 | transmembrane and coiled-coil domains 1 | -2.30557 |
| CYB5R1 | cytochrome b5 reductase 1 | -2.29752 |
| DCK | deoxycytidine kinase | -2.28945 |
| SS18L2 | synovial sarcoma translocation gene on chromosome 18-like 2 | -2.27064 |
| NUP85 | nucleoporin 85kDa | -2.25937 |
| KIF4A | kinesin family member 4A | -2.2454 |
| TEDC2 | tubulin epsilon and delta complex 2 | -2.24473 |
| KIF14 | kinesin family member 14 | -2.20771 |
| TBC1D10C | TBC1 domain family, member 10C | -2.1938 |
| LAP3 | leucine aminopeptidase 3 | -2.1891 |
| KIF15 | kinesin family member 15 | -2.17438 |
| PARPBP | PARP1 binding protein | -2.17194 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | -2.1485 |
| LMNB1 | lamin B1 | -2.12941 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | -2.12469 |
| PGRMC1 | progesterone receptor membrane component 1 | -2.12335 |
| DEF8 | differentially expressed in FDCP 8 homolog (mouse) | -2.10559 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.09919 |
| YME1L1 | YME1-like 1 ATPase | -2.08297 |
| CHEK2 | checkpoint kinase 2 | -2.06913 |
| EMD | emerin | -2.06823 |
| CKAP2 | cytoskeleton associated protein 2 | -2.05438 |
| MLEC | malectin | -2.05404 |
| MCM10 | minichromosome maintenance complex component 10 | -2.05128 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | -2.04737 |
| FIRRM | FIGNL1 interacting regulator of recombination and mitosis | -2.03951 |
| C5 | complement component 5 | -2.02842 |
| ARF5 | ADP-ribosylation factor 5 | -2.01005 |
| ADORA2A | adenosine A2a receptor | -2.00997 |
| SDHAF1 | succinate dehydrogenase complex assembly factor 1 | -2.00383 |
| UPF2 | UPF2 regulator of nonsense transcripts homolog (yeast) | -2.00322 |
| RPN1 | ribophorin I | -2.00279 |
