CRCGN014_HEPG2_24H:B16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caffeine 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

95 genes differentially expressed following the CRCGN014_HEPG2_24H:B16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 5.94397
CNPY3 canopy FGF signaling regulator 3 5.655
INPP1 inositol polyphosphate-1-phosphatase 5.22292
CDPF1 cysteine-rich, DPF motif domain containing 1 5.0301
TXNRD1 thioredoxin reductase 1 4.42244
ADGRE5 adhesion G protein-coupled receptor E5 4.26632
PHKA1 phosphorylase kinase, alpha 1 (muscle) 4.24945
SFTPB surfactant protein B 4.15327
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.05704
FOSL1 FOS-like antigen 1 3.81853
STK10 serine/threonine kinase 10 3.50803
UBQLN2 ubiquilin 2 3.50349
TRIB3 tribbles pseudokinase 3 3.49403
PPARG peroxisome proliferator-activated receptor gamma 3.47825
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.46475
ZFP36 ZFP36 ring finger protein 3.38242
SQSTM1 sequestosome 1 3.30083
IER3 immediate early response 3 3.28307
MEF2C myocyte enhancer factor 2C 3.23126
MVP major vault protein 3.11015
LCN2 lipocalin 2 3.04839
MAP7 microtubule-associated protein 7 3.00488
STX1A syntaxin 1A (brain) 2.95707
CCP110 centriolar coiled coil protein 110kDa 2.82096
CDK7 cyclin-dependent kinase 7 2.72645
EGR1 early growth response 1 2.65162
SQOR sulfide quinone oxidoreductase 2.63339
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.55203
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.55138
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.51861
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.51323
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 2.49572
MBNL2 muscleblind-like splicing regulator 2 2.46653
CASC3 cancer susceptibility candidate 3 2.32993
UBA1 ubiquitin-like modifier activating enzyme 1 2.31255
YARS1 tyrosyl-tRNA synthetase 1 2.29702
CYCS cytochrome c, somatic 2.28917
TUBB6 tubulin, beta 6 class V 2.28082
WBP2 WW domain binding protein 2 2.24988
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.23393
RALB v-ral simian leukemia viral oncogene homolog B 2.2297
GRB10 growth factor receptor-bound protein 10 2.17812
ABHD4 abhydrolase domain containing 4 2.15581
NANOS3 nanos homolog 3 (Drosophila) 2.11661
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.11479
BLVRA biliverdin reductase A 2.10379
TEX10 testis expressed 10 2.09849
IL4R interleukin 4 receptor 2.08717
GARS1 glycyl-tRNA synthetase 1 2.0678
RAB7A RAB7A, member RAS oncogene family 2.05979
CDC45 cell division cycle 45 2.05724
GTPBP2 GTP binding protein 2 2.01906
VAT1 vesicle amine transport 1 2.00752
ACOT9 acyl-CoA thioesterase 9 2.00271
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.00056

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
PCNA proliferating cell nuclear antigen -6.76995
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.58401
ZNF586 zinc finger protein 586 -4.52047
HAT1 histone acetyltransferase 1 -4.49283
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.2177
PLK1 polo-like kinase 1 -4.12477
PEG10 paternally expressed 10 -3.71435
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.65094
CCNB1 cyclin B1 -3.64202
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.32543
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -3.27401
ZW10 zw10 kinetochore protein -3.13213
ISOC1 isochorismatase domain containing 1 -3.13178
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.96922
TCTN1 tectonic family member 1 -2.91364
FBXO7 F-box protein 7 -2.8935
ALDOC aldolase C, fructose-bisphosphate -2.83572
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.74709
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.70374
RFC2 replication factor C (activator 1) 2, 40kDa -2.69914
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.66174
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.63726
RBM15B RNA binding motif protein 15B -2.62798
EIF5 eukaryotic translation initiation factor 5 -2.62623
DSG2 desmoglein 2 -2.57726
CRELD2 cysteine-rich with EGF-like domains 2 -2.45884
PSRC1 proline/serine-rich coiled-coil 1 -2.27204
PDZD2 PDZ domain containing 2 -2.24562
PDIA3 protein disulfide isomerase family A, member 3 -2.24131
SOAT2 sterol O-acyltransferase 2 -2.22616
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.21506
MED22 mediator complex subunit 22 -2.20075
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.1987
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.1977
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.08207
TNIP1 TNFAIP3 interacting protein 1 -2.04738
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.0437
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.03724
CCNA2 cyclin A2 -2.02852