| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | o-aminoazotoluene 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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137 genes differentially expressed following the CRCGN014_HEPG2_24H:B22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 5.51239 |
| VAT1 | vesicle amine transport 1 | 4.5975 |
| RAP1GAP | RAP1 GTPase activating protein | 4.45733 |
| PPARG | peroxisome proliferator-activated receptor gamma | 4.23643 |
| ABHD4 | abhydrolase domain containing 4 | 4.04895 |
| FOXO4 | forkhead box O4 | 3.99298 |
| TXNRD1 | thioredoxin reductase 1 | 3.99137 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 3.94472 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 3.9421 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 3.83874 |
| KDM5A | lysine (K)-specific demethylase 5A | 3.67453 |
| DIPK1A | divergent protein kinase domain 1A | 3.54424 |
| NUCB2 | nucleobindin 2 | 3.44177 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 3.43576 |
| PLS1 | plastin 1 | 3.42998 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 3.38574 |
| MVP | major vault protein | 3.37449 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 3.28792 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 3.26196 |
| SQSTM1 | sequestosome 1 | 3.18745 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | 3.16677 |
| KIFBP | kinesin family binding protein | 3.13667 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 3.0372 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 2.99149 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | 2.95788 |
| UGDH | UDP-glucose 6-dehydrogenase | 2.91192 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.89293 |
| ZFP36 | ZFP36 ring finger protein | 2.89219 |
| SKIC2 | SKI2 subunit of superkiller complex | 2.86825 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 2.84044 |
| SFTPB | surfactant protein B | 2.83706 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 2.70732 |
| CHN1 | chimerin 1 | 2.69442 |
| TRIM16 | tripartite motif containing 16 | 2.68467 |
| MAP7 | microtubule-associated protein 7 | 2.64761 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 2.61718 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.56783 |
| ANKRD10 | ankyrin repeat domain 10 | 2.5564 |
| CBR1 | carbonyl reductase 1 | 2.50781 |
| CYP11B2 | cytochrome P450, family 11, subfamily B, polypeptide 2 | 2.49106 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 2.48652 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.43208 |
| ANKRA2 | ankyrin repeat, family A (RFXANK-like), 2 | 2.39631 |
| CCL2 | chemokine (C-C motif) ligand 2 | 2.37728 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 2.32619 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.30968 |
| ZBTB35 | zinc finger and BTB domain containing 35 | 2.29311 |
| STX4 | syntaxin 4 | 2.27674 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 2.23393 |
| MUC13 | mucin 13, cell surface associated | 2.22731 |
| HMOX1 | heme oxygenase 1 | 2.21901 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 2.21528 |
| BBC3 | BCL2 binding component 3 | 2.21258 |
| KEAP1 | kelch-like ECH-associated protein 1 | 2.20795 |
| STAP2 | signal transducing adaptor family member 2 | 2.20589 |
| CYTH1 | cytohesin 1 | 2.19628 |
| PRKCD | protein kinase C, delta | 2.167 |
| ZMYM2 | zinc finger, MYM-type 2 | 2.15883 |
| INPP1 | inositol polyphosphate-1-phosphatase | 2.12722 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | 2.12344 |
| FBXW4 | F-box and WD repeat domain containing 4 | 2.11577 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 2.10157 |
| KCTD5 | potassium channel tetramerization domain containing 5 | 2.08901 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | 2.05979 |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 2.04569 |
| FAH | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 2.03857 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | 2.03136 |
| PHGDH | phosphoglycerate dehydrogenase | 2.02088 |
| MMUT | methylmalonyl-CoA mutase | 2.00966 |
| BSDC1 | BSD domain containing 1 | 2.00711 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC35F2 | solute carrier family 35, member F2 | -8.47322 |
| CDC20 | cell division cycle 20 | -6.38475 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -5.11807 |
| PLK1 | polo-like kinase 1 | -5.09091 |
| TCTN1 | tectonic family member 1 | -4.48532 |
| CDK1 | cyclin-dependent kinase 1 | -4.38823 |
| MELK | maternal embryonic leucine zipper kinase | -4.2439 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -4.22689 |
| DNM1L | dynamin 1-like | -3.83463 |
| CCNA2 | cyclin A2 | -3.83079 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | -3.81568 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -3.70834 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.65714 |
| TCERG1 | transcription elongation regulator 1 | -3.55828 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -3.52449 |
| TSPAN4 | tetraspanin 4 | -3.46404 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -3.46319 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -3.43275 |
| SPAG4 | sperm associated antigen 4 | -3.40849 |
| TLR4 | toll-like receptor 4 | -3.35532 |
| LBR | lamin B receptor | -3.28541 |
| GTF2A2 | general transcription factor IIA, 2, 12kDa | -3.23507 |
| FGFR4 | fibroblast growth factor receptor 4 | -3.22572 |
| HMGA2 | high mobility group AT-hook 2 | -3.21506 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.15051 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | -3.14517 |
| POLR1A | polymerase (RNA) I polypeptide A, 194kDa | -3.09363 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -3.05731 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -3.00016 |
| HAT1 | histone acetyltransferase 1 | -2.96297 |
| IER3 | immediate early response 3 | -2.94966 |
| CAB39 | calcium binding protein 39 | -2.94073 |
| ZNF586 | zinc finger protein 586 | -2.89462 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.8707 |
| AURKB | aurora kinase B | -2.84568 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.82687 |
| PGAM4 | phosphoglycerate mutase family member 4 | -2.73676 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | -2.73522 |
| CDCA8 | cell division cycle associated 8 | -2.70171 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.62264 |
| FAIM | Fas apoptotic inhibitory molecule | -2.55762 |
| CEP55 | centrosomal protein 55kDa | -2.50509 |
| CCNF | cyclin F | -2.48462 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | -2.4563 |
| RGS2 | regulator of G-protein signaling 2 | -2.43971 |
| DERA | deoxyribose-phosphate aldolase (putative) | -2.43165 |
| KIF4A | kinesin family member 4A | -2.38761 |
| RPIA | ribose 5-phosphate isomerase A | -2.33834 |
| STMN1 | stathmin 1 | -2.33623 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.32425 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -2.31041 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | -2.21051 |
| SOAT2 | sterol O-acyltransferase 2 | -2.17991 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -2.17446 |
| EXT1 | exostosin glycosyltransferase 1 | -2.17044 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | -2.12995 |
| NFIL3 | nuclear factor, interleukin 3 regulated | -2.11419 |
| RGS4 | regulator of G-protein signaling 4 | -2.08129 |
| STOML1 | stomatin (EPB72)-like 1 | -2.07306 |
| CCNB1 | cyclin B1 | -2.06935 |
| PUF60 | poly-U binding splicing factor 60KDa | -2.06546 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -2.03333 |
| ZNF274 | zinc finger protein 274 | -2.02418 |
| DEPDC1 | DEP domain containing 1 | -2.02418 |
| MRPL17 | mitochondrial ribosomal protein L17 | -2.02395 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -2.01311 |
| TUBA3E | tubulin, alpha 3e | -2.00738 |
