CRCGN014_HEPG2_24H:C03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetrakis(hydroxymethyl)phosphonium sulfate 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

221 genes differentially expressed following the CRCGN014_HEPG2_24H:C03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 7.32862
PNKP polynucleotide kinase 3'-phosphatase 6.93487
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.82919
NOTCH1 notch 1 6.44658
CARMIL1 capping protein regulator and myosin 1 linker 1 5.74967
ATP11B ATPase, class VI, type 11B 5.38184
CCDC92 coiled-coil domain containing 92 4.01078
GPER1 G protein-coupled estrogen receptor 1 3.89388
E2F2 E2F transcription factor 2 3.86804
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.81093
ADGRE5 adhesion G protein-coupled receptor E5 3.80167
ADRB2 adrenoceptor beta 2, surface 3.66248
ABHD4 abhydrolase domain containing 4 3.56534
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.50254
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.43071
AMDHD2 amidohydrolase domain containing 2 3.42986
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.41623
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.33726
KLHL21 kelch-like family member 21 3.31938
ANO1 anoctamin 1, calcium activated chloride channel 3.29845
LAGE3 L antigen family, member 3 3.26483
MINDY1 MINDY lysine 48 deubiquitinase 1 3.26201
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 3.22855
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.17639
HDGFL3 HDGF like 3 3.15346
CXCL2 chemokine (C-X-C motif) ligand 2 3.06395
MOK MOK protein kinase 3.03951
CHMP6 charged multivesicular body protein 6 3.01325
EPHB2 EPH receptor B2 3.00175
CRTAP cartilage associated protein 2.96043
SYNE2 spectrin repeat containing, nuclear envelope 2 2.92016
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.91448
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.90446
EPN2 epsin 2 2.90382
DOCK1 dedicator of cytokinesis 1 2.89818
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.88193
LAG3 lymphocyte-activation gene 3 2.85385
PPARG peroxisome proliferator-activated receptor gamma 2.81533
TTPA tocopherol (alpha) transfer protein 2.77934
CEP85 centrosomal protein 85kDa 2.7561
BZW2 basic leucine zipper and W2 domains 2 2.75276
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.73911
TIAM1 T-cell lymphoma invasion and metastasis 1 2.70228
DIPK1A divergent protein kinase domain 1A 2.70193
VAV3 vav 3 guanine nucleotide exchange factor 2.64895
NFIL3 nuclear factor, interleukin 3 regulated 2.64107
CGRRF1 cell growth regulator with ring finger domain 1 2.60738
KDM5A lysine (K)-specific demethylase 5A 2.55554
PEX11A peroxisomal biogenesis factor 11 alpha 2.46845
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2.46836
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.45506
MTNR1A melatonin receptor 1A 2.44478
PFKL phosphofructokinase, liver 2.39332
GATA3 GATA binding protein 3 2.38879
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 2.3699
BICRA BRD4 interacting chromatin remodeling complex associated protein 2.36155
IL26 interleukin 26 2.36148
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 2.35797
NUCB2 nucleobindin 2 2.35271
KIF13A kinesin family member 13A 2.3461
ETAA1 Ewing tumor-associated antigen 1 2.33688
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.32893
SQSTM1 sequestosome 1 2.3287
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.32541
LGALS14 lectin, galactoside-binding, soluble, 14 2.31067
IL21 interleukin 21 2.3102
IDE insulin-degrading enzyme 2.31017
UGDH UDP-glucose 6-dehydrogenase 2.292
CCL16 chemokine (C-C motif) ligand 16 2.28824
CEP97 centrosomal protein 97kDa 2.28652
EAPP E2F-associated phosphoprotein 2.27967
TBC1D17 TBC1 domain family, member 17 2.27274
SLC66A3 solute carrier family 66 member 3 2.2678
EPHB3 EPH receptor B3 2.25898
ABHD6 abhydrolase domain containing 6 2.25823
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.25324
ZIC4 Zic family member 4 2.2485
HOXB13 homeobox B13 2.23602
GREB1L growth regulation by estrogen in breast cancer-like 2.23219
NRG2 neuregulin 2 2.22988
PDZD7 PDZ domain containing 7 2.21138
TXNRD1 thioredoxin reductase 1 2.20661
LONP2 lon peptidase 2, peroxisomal 2.20054
LUZP4 leucine zipper protein 4 2.20032
SLC75A1 solute carrier family 75 member 1 2.1996
MEX3C mex-3 RNA binding family member C 2.19319
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 2.1903
IFNA6 interferon, alpha 6 2.18192
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.17919
SERF1A small EDRK-rich factor 1A (telomeric) 2.16994
SCN10A sodium channel, voltage gated, type X alpha subunit 2.16967
AXIN1 axin 1 2.16947
LAMA4 laminin, alpha 4 2.16653
ULBP1 UL16 binding protein 1 2.16605
GEMIN7 gem (nuclear organelle) associated protein 7 2.15406
ZNF660-ZNF197 ZNF660-ZNF197 readthrough 2.15033
CILK1 ciliogenesis associated kinase 1 2.14708
GSTZ1 glutathione S-transferase zeta 1 2.1423
CNTLN centlein, centrosomal protein 2.13849
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 2.13481
MDM4 MDM4, p53 regulator 2.13391
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 2.12437
KRTAP1-3 keratin associated protein 1-3 2.12413
PGPEP1 pyroglutamyl-peptidase I 2.12023
PMM2 phosphomannomutase 2 2.11955
RGSL1 regulator of G-protein signaling like 1 2.1181
VGLL4 vestigial-like family member 4 2.11638
SIRT3 sirtuin 3 2.09868
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.09588
DENND2D DENN/MADD domain containing 2D 2.09463
WIF1 WNT inhibitory factor 1 2.09224
FBN2 fibrillin 2 2.09061
ZNF446 zinc finger protein 446 2.08876
LOC122526780 uncharacterized LOC122526780 2.07808
SH2D3C SH2 domain containing 3C 2.06982
STIMATE STIM activating enhancer 2.0662
PCDHGA10 protocadherin gamma subfamily A, 10 2.06577
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 2.06152
YTHDC2 YTH domain containing 2 2.06101
SPTBN5 spectrin, beta, non-erythrocytic 5 2.05645
EPHA3 EPH receptor A3 2.05636
STRA6 stimulated by retinoic acid 6 2.0545
DMTF1 cyclin D binding myb-like transcription factor 1 2.05271
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 2.05209
IDUA iduronidase, alpha-L- 2.05099
LZTR1 leucine-zipper-like transcription regulator 1 2.04889
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.04759
DAPK2 death-associated protein kinase 2 2.03905
SELE selectin E 2.03657
RANBP17 RAN binding protein 17 2.0357
RPA4 replication protein A4, 30kDa 2.03493
MID2 midline 2 2.03383
NPFF neuropeptide FF-amide peptide precursor 2.03381
KATNIP katanin interacting protein 2.03324
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 2.02871
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.0252
MBIP MAP3K12 binding inhibitory protein 1 2.01137
LYN LYN proto-oncogene, Src family tyrosine kinase 2.01126
CABP5 calcium binding protein 5 2.01099
COPZ2 coatomer protein complex, subunit zeta 2 2.00817
TAS2R7 taste receptor, type 2, member 7 2.00786
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 2.00252
POU3F4 POU class 3 homeobox 4 2.00091
PRH1-TAS2R14 PRH1-TAS2R14 readthrough 2.00081

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -6.58865
RFC2 replication factor C (activator 1) 2, 40kDa -6.5285
CCNB2 cyclin B2 -5.37342
PEG10 paternally expressed 10 -5.27965
CDC20 cell division cycle 20 -4.98417
CCNB1 cyclin B1 -4.5388
PLK1 polo-like kinase 1 -4.53526
THAP11 THAP domain containing 11 -4.04018
CCDC86 coiled-coil domain containing 86 -4.03395
MRPS2 mitochondrial ribosomal protein S2 -3.9948
MAPK13 mitogen-activated protein kinase 13 -3.81709
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.79515
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.75496
KDM3A lysine (K)-specific demethylase 3A -3.60143
FBXL12 F-box and leucine-rich repeat protein 12 -3.58417
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.57841
TUBB6 tubulin, beta 6 class V -3.57505
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.57042
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.53537
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -3.51954
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.47814
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.44874
ZDHHC6 zinc finger, DHHC-type containing 6 -3.44288
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.42991
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.39851
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.39782
LAP3 leucine aminopeptidase 3 -3.36919
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.36419
DSG2 desmoglein 2 -3.34573
C2CD5 C2 calcium-dependent domain containing 5 -3.34239
ZW10 zw10 kinetochore protein -3.33346
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.26176
GTPBP8 GTP-binding protein 8 (putative) -3.25273
DUSP6 dual specificity phosphatase 6 -3.12077
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.07863
VAT1 vesicle amine transport 1 -2.98308
LDHD lactate dehydrogenase D -2.9419
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.91568
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.85863
NVL nuclear VCP-like -2.84845
TSPAN4 tetraspanin 4 -2.83646
ACOT9 acyl-CoA thioesterase 9 -2.72866
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.71123
TLCD3A TLC domain containing 3A -2.70278
MPHOSPH6 M-phase phosphoprotein 6 -2.68927
YME1L1 YME1-like 1 ATPase -2.63431
CHMP4B charged multivesicular body protein 4B -2.61145
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.59193
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.55308
TOR1A torsin family 1, member A (torsin A) -2.53114
WASHC4 WASH complex subunit 4 -2.51747
TRIB3 tribbles pseudokinase 3 -2.5029
GALP galanin-like peptide -2.49196
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.48879
TM9SF3 transmembrane 9 superfamily member 3 -2.48717
NGRN neugrin, neurite outgrowth associated -2.28005
EIF5 eukaryotic translation initiation factor 5 -2.27253
COG2 component of oligomeric golgi complex 2 -2.25799
LIAS lipoic acid synthetase -2.25359
PRDX4 peroxiredoxin 4 -2.23921
UBE2C ubiquitin-conjugating enzyme E2C -2.21899
FGFR4 fibroblast growth factor receptor 4 -2.20566
INTS5 integrator complex subunit 5 -2.1766
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.16812
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.16335
EMC8 ER membrane protein complex subunit 8 -2.14748
LYPLA1 lysophospholipase I -2.14477
EIF3I eukaryotic translation initiation factor 3, subunit I -2.13064
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.11121
NT5DC2 5'-nucleotidase domain containing 2 -2.08089
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -2.06677
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -2.06585
TRIAP1 TP53 regulated inhibitor of apoptosis 1 -2.05744
EIF1B eukaryotic translation initiation factor 1B -2.05136
GNAS GNAS complex locus -2.03496
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.02979
TMEM248 transmembrane protein 248 -2.00398