| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | n-phenyl-p-phenylenediamine.hcl 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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90 genes differentially expressed following the CRCGN014_HEPG2_24H:C04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DYNLT3 | dynein, light chain, Tctex-type 3 | 4.90316 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 4.48456 |
| MAP7 | microtubule-associated protein 7 | 4.37054 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 3.99211 |
| CDC25B | cell division cycle 25B | 3.95903 |
| PNKP | polynucleotide kinase 3'-phosphatase | 3.90928 |
| CBR3 | carbonyl reductase 3 | 3.73909 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 3.63016 |
| ADRB2 | adrenoceptor beta 2, surface | 3.50133 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 3.47216 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 3.39481 |
| HOXA5 | homeobox A5 | 3.27442 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 3.19709 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.15615 |
| IDE | insulin-degrading enzyme | 3.00676 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 2.97766 |
| MICALL1 | MICAL-like 1 | 2.95431 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 2.87734 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 2.84886 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 2.82002 |
| ABHD4 | abhydrolase domain containing 4 | 2.8199 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | 2.81885 |
| BLCAP | bladder cancer associated protein | 2.78575 |
| GAA | glucosidase, alpha; acid | 2.76066 |
| ABHD6 | abhydrolase domain containing 6 | 2.71132 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 2.68344 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 2.50207 |
| BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 | 2.49805 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 2.45945 |
| ZNF589 | zinc finger protein 589 | 2.41248 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | 2.37322 |
| SMIM40 | small integral membrane protein 40 | 2.35889 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 2.35369 |
| ANO10 | anoctamin 10 | 2.29438 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | 2.28146 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 2.26367 |
| CCNF | cyclin F | 2.25604 |
| INPP1 | inositol polyphosphate-1-phosphatase | 2.24969 |
| ELAC2 | elaC ribonuclease Z 2 | 2.20466 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | 2.19908 |
| HSPA1A | heat shock 70kDa protein 1A | 2.19675 |
| PSME2 | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 2.19585 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) | 2.18972 |
| LAGE3 | L antigen family, member 3 | 2.17763 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.174 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.16347 |
| CYCS | cytochrome c, somatic | 2.14963 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.14102 |
| BLMH | bleomycin hydrolase | 2.07034 |
| SQSTM1 | sequestosome 1 | 2.0326 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -6.68771 |
| LDHD | lactate dehydrogenase D | -6.55575 |
| RPIA | ribose 5-phosphate isomerase A | -4.20638 |
| HYOU1 | hypoxia up-regulated 1 | -4.16752 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -3.99348 |
| TRIB3 | tribbles pseudokinase 3 | -3.82256 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -3.66191 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -3.55729 |
| GOLT1B | golgi transport 1B | -3.52668 |
| CCDC86 | coiled-coil domain containing 86 | -3.51019 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -3.43185 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.37003 |
| SLC35F2 | solute carrier family 35, member F2 | -3.29648 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -3.1429 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -3.04193 |
| ADI1 | acireductone dioxygenase 1 | -2.99011 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -2.92994 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.8407 |
| ZNF586 | zinc finger protein 586 | -2.74726 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.72365 |
| S100A4 | S100 calcium binding protein A4 | -2.69598 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -2.6509 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -2.65046 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -2.64549 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.60911 |
| EDN1 | endothelin 1 | -2.46552 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.44134 |
| GNAS | GNAS complex locus | -2.31478 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -2.2347 |
| SCG5 | secretogranin V | -2.19851 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -2.15713 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.112 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -2.09061 |
| AVEN | apoptosis, caspase activation inhibitor | -2.08428 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -2.06116 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -2.0593 |
| TIMM10 | translocase of inner mitochondrial membrane 10 homolog (yeast) | -2.04519 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | -2.03551 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -2.01559 |
| MYBPC2 | myosin binding protein C, fast type | -2.01001 |
