CRCGN014_HEPG2_24H:C06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caprolactam 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN014_HEPG2_24H:C06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.12198
CXCL2 chemokine (C-X-C motif) ligand 2 5.6019
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.42122
GPER1 G protein-coupled estrogen receptor 1 3.27574
MYLK myosin light chain kinase 3.23259
PEX11A peroxisomal biogenesis factor 11 alpha 3.2155
DIPK1A divergent protein kinase domain 1A 3.12195
BACE2 beta-site APP-cleaving enzyme 2 2.8361
GPATCH8 G patch domain containing 8 2.80182
PLSCR3 phospholipid scramblase 3 2.58479
CSK c-src tyrosine kinase 2.45678
MAP7 microtubule-associated protein 7 2.18574
CXCL6 chemokine (C-X-C motif) ligand 6 2.1853
DMAC2L distal membrane arm assembly component 2 like 2.10015
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.05767
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.03404

decreased expression

Symbol Name Standardized Value
LAP3 leucine aminopeptidase 3 -4.57732
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.27119
ZNF586 zinc finger protein 586 -3.62022
ZDHHC6 zinc finger, DHHC-type containing 6 -3.34768
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.09051
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.9992
GNAS GNAS complex locus -2.48042
NGRN neugrin, neurite outgrowth associated -2.3752
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.31593
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.17477
DNM1L dynamin 1-like -2.15
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.12605
CDC20 cell division cycle 20 -2.04253