| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | n-vinylpyrrolidone-2 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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63 genes differentially expressed following the CRCGN014_HEPG2_24H:C08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 6.96378 |
| PNKP | polynucleotide kinase 3'-phosphatase | 5.18313 |
| MAMLD1 | mastermind-like domain containing 1 | 4.53838 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 4.39553 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 4.32599 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 4.29618 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 4.26439 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 4.24856 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 4.175 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.98552 |
| PRR15L | proline rich 15-like | 3.91443 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 3.79592 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 3.59908 |
| MEF2C | myocyte enhancer factor 2C | 3.22594 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.06182 |
| PFKL | phosphofructokinase, liver | 2.95745 |
| ABHD6 | abhydrolase domain containing 6 | 2.93588 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.93193 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.45757 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 2.44006 |
| MMP1 | matrix metallopeptidase 1 | 2.42217 |
| OPCML | opioid binding protein/cell adhesion molecule-like | 2.26149 |
| MAOB | monoamine oxidase B | 2.22379 |
| AAR2 | AAR2 splicing factor homolog (S. cerevisiae) | 2.22225 |
| EPN2 | epsin 2 | 2.21312 |
| MDM4 | MDM4, p53 regulator | 2.19473 |
| DGKG | diacylglycerol kinase, gamma 90kDa | 2.0941 |
| AGPAT3 | 1-acylglycerol-3-phosphate O-acyltransferase 3 | 2.08161 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 2.07582 |
| APBB1IP | amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein | 2.0484 |
| EDA2R | ectodysplasin A2 receptor | 2.01469 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -5.08517 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -5.0398 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -4.57104 |
| TP53BP2 | tumor protein p53 binding protein 2 | -4.48033 |
| PCNA | proliferating cell nuclear antigen | -4.38371 |
| SLC35F2 | solute carrier family 35, member F2 | -4.17452 |
| TLR4 | toll-like receptor 4 | -3.91011 |
| RGS2 | regulator of G-protein signaling 2 | -3.72884 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.50628 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -3.21888 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -3.03782 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.9801 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -2.94495 |
| KDM3A | lysine (K)-specific demethylase 3A | -2.92302 |
| HSPB1 | heat shock 27kDa protein 1 | -2.84807 |
| VAT1 | vesicle amine transport 1 | -2.83911 |
| MACF1 | microtubule-actin crosslinking factor 1 | -2.65737 |
| CD320 | CD320 molecule | -2.5904 |
| CCNB2 | cyclin B2 | -2.58993 |
| DUSP6 | dual specificity phosphatase 6 | -2.58046 |
| LDHD | lactate dehydrogenase D | -2.51902 |
| CD58 | CD58 molecule | -2.41993 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -2.37953 |
| WASHC4 | WASH complex subunit 4 | -2.32969 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -2.31647 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -2.23131 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.19672 |
| RPS5 | ribosomal protein S5 | -2.18679 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -2.13489 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | -2.1033 |
| RGS5 | regulator of G-protein signaling 5 | -2.10112 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -2.05737 |
