CRCGN014_HEPG2_24H:C09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description bromodichloromethane 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

97 genes differentially expressed following the CRCGN014_HEPG2_24H:C09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MOK MOK protein kinase 9.83023
MAP7 microtubule-associated protein 7 7.49769
CIAO3 cytosolic iron-sulfur assembly component 3 7.12589
CXCL2 chemokine (C-X-C motif) ligand 2 5.50005
NOTCH1 notch 1 5.41343
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.74944
CHN1 chimerin 1 4.54409
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.50784
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.45139
MAMLD1 mastermind-like domain containing 1 3.26091
GPER1 G protein-coupled estrogen receptor 1 3.16288
BZW2 basic leucine zipper and W2 domains 2 3.06942
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 2.80804
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.79245
EGF epidermal growth factor 2.79134
NOSIP nitric oxide synthase interacting protein 2.7711
CCNF cyclin F 2.72528
ECEL1 endothelin converting enzyme-like 1 2.67384
LPAR2 lysophosphatidic acid receptor 2 2.66107
MYLK myosin light chain kinase 2.64632
SQOR sulfide quinone oxidoreductase 2.59688
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 2.59072
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.53843
ADGRE5 adhesion G protein-coupled receptor E5 2.47118
RXYLT1 ribitol xylosyltransferase 1 2.44261
DMTF1 cyclin D binding myb-like transcription factor 1 2.33676
BACE2 beta-site APP-cleaving enzyme 2 2.33249
CAPN11 calpain 11 2.30071
CLDN6 claudin 6 2.29464
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.2934
CHRM3 cholinergic receptor, muscarinic 3 2.28743
ACE2 angiotensin I converting enzyme 2 2.23031
CYCS cytochrome c, somatic 2.22502
ROPN1B rhophilin associated tail protein 1B 2.18995
HGD homogentisate 1,2-dioxygenase 2.18599
LEMD3 LEM domain containing 3 2.18226
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) 2.15545
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.14025
NECAB2 N-terminal EF-hand calcium binding protein 2 2.13896
SSUH2 ssu-2 homolog (C. elegans) 2.13553
PLA2G3 phospholipase A2, group III 2.12593
SLC30A3 solute carrier family 30 (zinc transporter), member 3 2.12437
NME2 NME/NM23 nucleoside diphosphate kinase 2 2.12351
SEC31B SEC31 homolog B (S. cerevisiae) 2.1163
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.11607
MTM1 myotubularin 1 2.10704
ADM2 adrenomedullin 2 2.08921
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.08311
TREML2 triggering receptor expressed on myeloid cells-like 2 2.08229
PNKP polynucleotide kinase 3'-phosphatase 2.08121
DUX4 double homeobox 4 2.07125
EVX1 even-skipped homeobox 1 2.0665
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma 2.05167
BCO1 beta-carotene oxygenase 1 2.0476
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 2.04231
MMP2 matrix metallopeptidase 2 2.02892
ZHX2 zinc fingers and homeoboxes 2 2.02606
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.01626

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.80778
KDM3A lysine (K)-specific demethylase 3A -6.35305
HACD3 3-hydroxyacyl-CoA dehydratase 3 -6.10619
TLR4 toll-like receptor 4 -5.20233
MRPS2 mitochondrial ribosomal protein S2 -4.90245
ZDHHC6 zinc finger, DHHC-type containing 6 -3.98333
TRIB3 tribbles pseudokinase 3 -3.75067
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.66061
ZNF586 zinc finger protein 586 -3.42409
CDC20 cell division cycle 20 -3.20589
ADI1 acireductone dioxygenase 1 -3.14444
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.04247
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.96742
CCNB2 cyclin B2 -2.90467
MRPS16 mitochondrial ribosomal protein S16 -2.88484
GOLT1B golgi transport 1B -2.78512
COG7 component of oligomeric golgi complex 7 -2.77389
TUBB6 tubulin, beta 6 class V -2.71055
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.65605
ZMIZ1 zinc finger, MIZ-type containing 1 -2.62335
CCDC86 coiled-coil domain containing 86 -2.6122
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.61193
CHMP4B charged multivesicular body protein 4B -2.61028
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.56602
THAP11 THAP domain containing 11 -2.42392
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing -2.34367
CLIC4 chloride intracellular channel 4 -2.34193
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.33137
YME1L1 YME1-like 1 ATPase -2.29342
ISOC1 isochorismatase domain containing 1 -2.29193
CAB39 calcium binding protein 39 -2.27765
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.22112
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.21702
RGS2 regulator of G-protein signaling 2 -2.12077
ABHD11 abhydrolase domain containing 11 -2.10895
HCAR3 hydroxycarboxylic acid receptor 3 -2.08943
HEATR1 HEAT repeat containing 1 -2.08571
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.0129