| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | maleic hydrazide 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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77 genes differentially expressed following the CRCGN014_HEPG2_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 6.10528 |
| SMIM40 | small integral membrane protein 40 | 5.48866 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.97943 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 3.71817 |
| LCN2 | lipocalin 2 | 3.57292 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.56221 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 3.43385 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 3.32742 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 3.29936 |
| NOTCH1 | notch 1 | 3.1977 |
| CCDC92 | coiled-coil domain containing 92 | 3.17415 |
| AMDHD2 | amidohydrolase domain containing 2 | 3.15472 |
| ADRB2 | adrenoceptor beta 2, surface | 2.91668 |
| BIRC2 | baculoviral IAP repeat containing 2 | 2.86967 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.84593 |
| MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | 2.83313 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 2.79859 |
| DDR1 | discoidin domain receptor tyrosine kinase 1 | 2.78781 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.77092 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 2.63715 |
| EPHB2 | EPH receptor B2 | 2.6226 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 2.565 |
| CYCS | cytochrome c, somatic | 2.46087 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 2.40369 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 2.3946 |
| KDM5A | lysine (K)-specific demethylase 5A | 2.25675 |
| PFKL | phosphofructokinase, liver | 2.21395 |
| PAGR1 | PAXIP1 associated glutamate-rich protein 1 | 2.10022 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 2.08879 |
| RING1 | ring finger protein 1 | 2.0866 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 2.07474 |
| GLI3 | GLI family zinc finger 3 | 2.06334 |
| FZD7 | frizzled class receptor 7 | 2.06062 |
| PRPF39 | pre-mRNA processing factor 39 | 2.05559 |
| GATA3 | GATA binding protein 3 | 2.02835 |
| TRAPPC8 | trafficking protein particle complex 8 | 2.02811 |
| AGPAT1 | 1-acylglycerol-3-phosphate O-acyltransferase 1 | 2.02802 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -7.05496 |
| PCNA | proliferating cell nuclear antigen | -5.2865 |
| UGDH | UDP-glucose 6-dehydrogenase | -3.94269 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -3.8419 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -3.73433 |
| KDM3A | lysine (K)-specific demethylase 3A | -3.72171 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -3.56026 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -3.55606 |
| CD320 | CD320 molecule | -3.51181 |
| GTPBP8 | GTP-binding protein 8 (putative) | -3.46194 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -3.39816 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -3.3689 |
| ZNF586 | zinc finger protein 586 | -3.31248 |
| CCDC86 | coiled-coil domain containing 86 | -3.30677 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.2986 |
| TRIB3 | tribbles pseudokinase 3 | -3.20385 |
| RPIA | ribose 5-phosphate isomerase A | -3.15433 |
| TSPAN4 | tetraspanin 4 | -3.13526 |
| CTSD | cathepsin D | -3.09155 |
| CCNB2 | cyclin B2 | -3.00899 |
| HMG20B | high mobility group 20B | -3.00565 |
| CD58 | CD58 molecule | -2.97138 |
| RGS2 | regulator of G-protein signaling 2 | -2.88452 |
| HAT1 | histone acetyltransferase 1 | -2.85496 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -2.84865 |
| CHMP4B | charged multivesicular body protein 4B | -2.72153 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.68961 |
| THAP11 | THAP domain containing 11 | -2.61511 |
| GNAS | GNAS complex locus | -2.58831 |
| LRPAP1 | low density lipoprotein receptor-related protein associated protein 1 | -2.49588 |
| SNX11 | sorting nexin 11 | -2.41252 |
| PLA2G4C | phospholipase A2, group IVC (cytosolic, calcium-independent) | -2.32336 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -2.22889 |
| NVL | nuclear VCP-like | -2.2247 |
| HSPBAP1 | HSPB (heat shock 27kDa) associated protein 1 | -2.20851 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -2.15628 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -2.13414 |
| SNTB2 | syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) | -2.12253 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -2.07127 |
| ANKRD10 | ankyrin repeat domain 10 | -2.05486 |
