CRCGN014_HEPG2_24H:C12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description geranyl acetate 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

78 genes differentially expressed following the CRCGN014_HEPG2_24H:C12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 7.81712
E2F2 E2F transcription factor 2 5.31255
ADRB2 adrenoceptor beta 2, surface 5.1531
ADGRE5 adhesion G protein-coupled receptor E5 5.09885
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.98087
UBQLN2 ubiquilin 2 4.92617
GSTZ1 glutathione S-transferase zeta 1 4.92512
MSRA methionine sulfoxide reductase A 4.88086
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.86032
LCN2 lipocalin 2 4.79948
CIAO3 cytosolic iron-sulfur assembly component 3 4.71957
CXCL2 chemokine (C-X-C motif) ligand 2 4.71888
PLS1 plastin 1 4.3666
AMDHD2 amidohydrolase domain containing 2 4.29911
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.0713
EPHA3 EPH receptor A3 3.75346
EPHB2 EPH receptor B2 3.68361
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.66146
ABHD6 abhydrolase domain containing 6 3.51221
PPARG peroxisome proliferator-activated receptor gamma 3.35046
PIH1D1 PIH1 domain containing 1 3.20708
TIAM1 T-cell lymphoma invasion and metastasis 1 3.15369
CCNF cyclin F 3.02579
HLA-DRA major histocompatibility complex, class II, DR alpha 2.99798
NOTCH1 notch 1 2.96855
KDM5A lysine (K)-specific demethylase 5A 2.86714
TBXA2R thromboxane A2 receptor 2.80554
EVL Enah/Vasp-like 2.74163
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.71354
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.71323
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.7074
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.61532
CCL2 chemokine (C-C motif) ligand 2 2.54404
CBR3 carbonyl reductase 3 2.50257
STIMATE STIM activating enhancer 2.39893
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.35786
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.29323
MAST2 microtubule associated serine/threonine kinase 2 2.23744
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.21622
MAGED2 melanoma antigen family D2 2.11808
CDK19 cyclin-dependent kinase 19 2.11279
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.1031
APOM apolipoprotein M 2.07599
MAP7 microtubule-associated protein 7 2.05473

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -5.19692
MRPS2 mitochondrial ribosomal protein S2 -5.17516
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.11176
NUP85 nucleoporin 85kDa -5.06162
CD320 CD320 molecule -5.02708
KDM3A lysine (K)-specific demethylase 3A -4.94047
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.73986
THAP11 THAP domain containing 11 -4.737
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.60756
GADD45A growth arrest and DNA-damage-inducible, alpha -4.47676
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.43783
SCAND1 SCAN domain containing 1 -3.98418
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.93861
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.7365
NGRN neugrin, neurite outgrowth associated -3.61356
PEG10 paternally expressed 10 -3.4539
RFC2 replication factor C (activator 1) 2, 40kDa -3.36159
YME1L1 YME1-like 1 ATPase -3.24061
SNX11 sorting nexin 11 -3.23346
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.1885
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.08489
TES testin LIM domain protein -3.03622
GTPBP8 GTP-binding protein 8 (putative) -2.7943
GNAS GNAS complex locus -2.67568
MAPK13 mitogen-activated protein kinase 13 -2.62303
RPS5 ribosomal protein S5 -2.52422
LOC124907782 dual specificity protein phosphatase 22 -2.43255
HMG20B high mobility group 20B -2.3585
EGF epidermal growth factor -2.29141
PCNA proliferating cell nuclear antigen -2.28554
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 -2.23857
KCTD2 potassium channel tetramerization domain containing 2 -2.12078
PFKP phosphofructokinase, platelet -2.07686
RPL8 ribosomal protein L8 -2.0293