CRCGN014_HEPG2_24H:C13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

77 genes differentially expressed following the CRCGN014_HEPG2_24H:C13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 6.5534
CXCL2 chemokine (C-X-C motif) ligand 2 5.98653
MAP7 microtubule-associated protein 7 5.55882
STK10 serine/threonine kinase 10 5.1795
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.38097
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.1377
PLS1 plastin 1 4.13712
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.03249
GSTZ1 glutathione S-transferase zeta 1 3.82452
NANOS3 nanos homolog 3 (Drosophila) 3.81904
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.65604
DENND2D DENN/MADD domain containing 2D 3.48903
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 3.48541
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.4603
LCN2 lipocalin 2 3.43289
MYLK myosin light chain kinase 3.42119
CCNF cyclin F 3.38492
E2F2 E2F transcription factor 2 3.23082
ABHD6 abhydrolase domain containing 6 3.21405
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.19444
PRKCH protein kinase C, eta 2.99895
SNAP25 synaptosomal-associated protein, 25kDa 2.86808
UBQLN2 ubiquilin 2 2.82543
CARMIL1 capping protein regulator and myosin 1 linker 1 2.69612
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.65164
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.61328
MTA2 metastasis associated 1 family, member 2 2.58683
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.50241
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.47088
RXYLT1 ribitol xylosyltransferase 1 2.46654
WWC3 WWC family member 3 2.45843
GPATCH8 G patch domain containing 8 2.30049
CEPT1 choline/ethanolamine phosphotransferase 1 2.29011
PNKP polynucleotide kinase 3'-phosphatase 2.28162
TIAM1 T-cell lymphoma invasion and metastasis 1 2.27504
KDM5A lysine (K)-specific demethylase 5A 2.22337
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.21764
HLA-DRA major histocompatibility complex, class II, DR alpha 2.19589
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.19378
GMPS guanine monphosphate synthase 2.18242
SATB1 SATB homeobox 1 2.17743
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.16228
MDC1 mediator of DNA-damage checkpoint 1 2.11263
FZD7 frizzled class receptor 7 2.09422
MOGAT1 monoacylglycerol O-acyltransferase 1 2.0749
CD244 CD244 molecule, natural killer cell receptor 2B4 2.04994
PKDREJ polycystin (PKD) family receptor for egg jelly 2.02233

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.46858
PEG10 paternally expressed 10 -5.90253
TLCD3A TLC domain containing 3A -4.52862
GDF15 growth differentiation factor 15 -4.15756
DSG2 desmoglein 2 -4.13453
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.0087
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.83426
MRPS2 mitochondrial ribosomal protein S2 -3.74243
TUBB6 tubulin, beta 6 class V -3.63406
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.49464
OXA1L oxidase (cytochrome c) assembly 1-like -3.47197
GADD45A growth arrest and DNA-damage-inducible, alpha -3.36662
PTPRK protein tyrosine phosphatase, receptor type, K -3.3544
THAP11 THAP domain containing 11 -3.29956
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.29053
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.2004
CHMP4B charged multivesicular body protein 4B -3.18701
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.15948
GOLT1B golgi transport 1B -3.1539
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.9714
TLR4 toll-like receptor 4 -2.92656
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.88779
GNAS GNAS complex locus -2.50767
NVL nuclear VCP-like -2.27758
TLE5 TLE family member 5, transcriptional modulator -2.27212
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.21648
CHIC2 cysteine-rich hydrophobic domain 2 -2.14174
CYREN cell cycle regulator of NHEJ -2.10776
COX5A cytochrome c oxidase subunit Va -2.04385
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.01222