CRCGN014_HEPG2_24H:C17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indole 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

72 genes differentially expressed following the CRCGN014_HEPG2_24H:C17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNPY3 canopy FGF signaling regulator 3 5.16619
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.92709
FCHO1 FCH domain only 1 4.88076
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.33316
CCDC92 coiled-coil domain containing 92 3.9393
MOK MOK protein kinase 3.79831
CXCL2 chemokine (C-X-C motif) ligand 2 3.68529
NOTCH1 notch 1 3.59725
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.58238
VAT1 vesicle amine transport 1 3.54048
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.47417
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.18392
CCL2 chemokine (C-C motif) ligand 2 3.1263
SOCS2 suppressor of cytokine signaling 2 3.10619
CBR3 carbonyl reductase 3 3.05442
NMU neuromedin U 2.98641
STIMATE STIM activating enhancer 2.96481
ATP11B ATPase, class VI, type 11B 2.82285
CDC45 cell division cycle 45 2.73487
TXNRD1 thioredoxin reductase 1 2.73117
RAP1GAP RAP1 GTPase activating protein 2.65158
ZNF652 zinc finger protein 652 2.61155
DIPK1A divergent protein kinase domain 1A 2.52034
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.51888
CRYZ crystallin, zeta (quinone reductase) 2.41427
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.39011
LPAR2 lysophosphatidic acid receptor 2 2.36249
CYCS cytochrome c, somatic 2.32269
GPER1 G protein-coupled estrogen receptor 1 2.30057
LCN2 lipocalin 2 2.28444
KIFBP kinesin family binding protein 2.28155
MVP major vault protein 2.17368
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.16856
PLS1 plastin 1 2.15396
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.15257
ZFP36 ZFP36 ring finger protein 2.15031
CTSL cathepsin L 2.13255
MTERF3 mitochondrial transcription termination factor 3 2.12709
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) 2.08792
BPHL biphenyl hydrolase-like (serine hydrolase) 2.0413
ZNF589 zinc finger protein 589 2.02103
GARRE1 granule associated Rac and RHOG effector 1 2.01825
STAP2 signal transducing adaptor family member 2 2.01798

decreased expression

Symbol Name Standardized Value
NGRN neugrin, neurite outgrowth associated -6.18425
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.07903
ACAA1 acetyl-CoA acyltransferase 1 -4.71207
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.68449
ADI1 acireductone dioxygenase 1 -4.37752
ARID5B AT rich interactive domain 5B (MRF1-like) -4.10717
RGS2 regulator of G-protein signaling 2 -3.91734
CD320 CD320 molecule -3.401
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.07268
OXA1L oxidase (cytochrome c) assembly 1-like -2.89527
TLR4 toll-like receptor 4 -2.68395
GOLT1B golgi transport 1B -2.57165
ISOC1 isochorismatase domain containing 1 -2.56805
PSRC1 proline/serine-rich coiled-coil 1 -2.51691
PDHX pyruvate dehydrogenase complex, component X -2.39097
TBC1D10C TBC1 domain family, member 10C -2.37153
TATDN2 TatD DNase domain containing 2 -2.36842
MELK maternal embryonic leucine zipper kinase -2.3563
TRIB3 tribbles pseudokinase 3 -2.33905
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -2.2795
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.27494
NCAPD2 non-SMC condensin I complex, subunit D2 -2.17413
FHL2 four and a half LIM domains 2 -2.15598
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.15205
CRELD2 cysteine-rich with EGF-like domains 2 -2.13015
LBR lamin B receptor -2.11499
TCTN1 tectonic family member 1 -2.10289
HAT1 histone acetyltransferase 1 -2.07441
ZNF226 zinc finger protein 226 -2.03995