CRCGN014_HEPG2_24H:C18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-(p-chlorophenyl)-1,1-di?methyl?urea 39.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

24 genes differentially expressed following the CRCGN014_HEPG2_24H:C18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MOK MOK protein kinase 4.477
C2CD2 C2 calcium-dependent domain containing 2 4.16408
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.04645
UBQLN2 ubiquilin 2 3.64019
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.4705
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.3763
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.10598
CXCL2 chemokine (C-X-C motif) ligand 2 2.91914
MINDY1 MINDY lysine 48 deubiquitinase 1 2.89087
CCNF cyclin F 2.69211
GPER1 G protein-coupled estrogen receptor 1 2.63732
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.54024
CORO1A coronin, actin binding protein, 1A 2.27489
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.23186
NOSIP nitric oxide synthase interacting protein 2.13687
STXBP2 syntaxin binding protein 2 2.06062

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -4.96229
LAP3 leucine aminopeptidase 3 -4.09585
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.86027
OXA1L oxidase (cytochrome c) assembly 1-like -3.42159
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.2084
LDHD lactate dehydrogenase D -2.79506
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.33244
CCNB2 cyclin B2 -2.08104