CRCGN014_HEPG2_24H:C22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description lithocholic-acid 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

97 genes differentially expressed following the CRCGN014_HEPG2_24H:C22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPP1R13B protein phosphatase 1, regulatory subunit 13B 6.93685
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.62005
ADGRE5 adhesion G protein-coupled receptor E5 6.11298
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.10425
CXCL2 chemokine (C-X-C motif) ligand 2 5.60645
CNPY3 canopy FGF signaling regulator 3 5.21273
CARMIL1 capping protein regulator and myosin 1 linker 1 4.74275
PRKCH protein kinase C, eta 4.06643
C2CD2 C2 calcium-dependent domain containing 2 3.96025
NOTCH1 notch 1 3.70584
BZW2 basic leucine zipper and W2 domains 2 3.61478
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.32225
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.26988
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.23735
SFTPB surfactant protein B 3.1877
MX1 MX dynamin-like GTPase 1 3.07542
SLC75A1 solute carrier family 75 member 1 2.94953
PLSCR1 phospholipid scramblase 1 2.91122
ATP11B ATPase, class VI, type 11B 2.87283
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.78728
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.78384
KIFBP kinesin family binding protein 2.76825
WDR7 WD repeat domain 7 2.72872
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.6889
ADRB2 adrenoceptor beta 2, surface 2.63684
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.57975
ISG15 ISG15 ubiquitin-like modifier 2.57373
CCL2 chemokine (C-C motif) ligand 2 2.54711
PRR15L proline rich 15-like 2.54676
IFI44L interferon-induced protein 44-like 2.52476
XAF1 XIAP associated factor 1 2.4948
GRB10 growth factor receptor-bound protein 10 2.46452
RAB21 RAB21, member RAS oncogene family 2.43658
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.43652
SQOR sulfide quinone oxidoreductase 2.42898
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.41627
MCOLN1 mucolipin 1 2.41372
EDN1 endothelin 1 2.39465
CBR3 carbonyl reductase 3 2.36102
SNAP25 synaptosomal-associated protein, 25kDa 2.35503
PPARG peroxisome proliferator-activated receptor gamma 2.35443
PNKP polynucleotide kinase 3'-phosphatase 2.3188
TATDN2 TatD DNase domain containing 2 2.31803
HDGFL3 HDGF like 3 2.26298
TREM1 triggering receptor expressed on myeloid cells 1 2.23854
TUBB6 tubulin, beta 6 class V 2.18124
DOK2 docking protein 2, 56kDa 2.14742
MVP major vault protein 2.14229
IFI6 interferon, alpha-inducible protein 6 2.09934
BACE2 beta-site APP-cleaving enzyme 2 2.08578
GSTA1 glutathione S-transferase alpha 1 2.07888
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.05416
OASL 2'-5'-oligoadenylate synthetase-like 2.02779
IFI44 interferon-induced protein 44 2.02504
CCP110 centriolar coiled coil protein 110kDa 2.02159
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.01908
RSAD2 radical S-adenosyl methionine domain containing 2 2.01491
FMO3 flavin containing monooxygenase 3 2.00988
GLRX glutaredoxin (thioltransferase) 2.00128

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
KDM3A lysine (K)-specific demethylase 3A -6.30558
PCNA proliferating cell nuclear antigen -5.30795
NGRN neugrin, neurite outgrowth associated -4.74142
CCNB2 cyclin B2 -4.64761
FBXL12 F-box and leucine-rich repeat protein 12 -4.14324
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.09396
CCDC86 coiled-coil domain containing 86 -3.76064
TCTN1 tectonic family member 1 -3.73633
FGFR4 fibroblast growth factor receptor 4 -3.68385
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.66256
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.57409
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.51263
MTA1 metastasis associated 1 -3.34318
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.32841
TM9SF3 transmembrane 9 superfamily member 3 -3.11172
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.07023
ADI1 acireductone dioxygenase 1 -3.05323
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.04383
DNM1L dynamin 1-like -3.00628
CD320 CD320 molecule -2.94572
ZDHHC6 zinc finger, DHHC-type containing 6 -2.8973
MRPS2 mitochondrial ribosomal protein S2 -2.61409
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.5165
PTCD1 pentatricopeptide repeat domain 1 -2.38165
ALDOC aldolase C, fructose-bisphosphate -2.33377
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.27342
MVD mevalonate (diphospho) decarboxylase -2.23591
FADS2 fatty acid desaturase 2 -2.22947
ISCU iron-sulfur cluster assembly enzyme -2.22874
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.21025
CETN2 centrin, EF-hand protein, 2 -2.18757
FHL2 four and a half LIM domains 2 -2.18703
PSRC1 proline/serine-rich coiled-coil 1 -2.18625
NCK1 NCK adaptor protein 1 -2.09182
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.0659
KCTD7 potassium channel tetramerization domain containing 7 -2.03903
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.00934