CRCGN014_HEPG2_24H:D02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aroclor 1260 38.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

151 genes differentially expressed following the CRCGN014_HEPG2_24H:D02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 9.45089
CNPY3 canopy FGF signaling regulator 3 6.51427
CTSL cathepsin L 5.84715
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.18909
EPN2 epsin 2 5.06448
PRAF2 PRA1 domain family, member 2 5.03723
CDC45 cell division cycle 45 4.72632
EGF epidermal growth factor 4.52697
MOK MOK protein kinase 4.43556
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.14709
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.12104
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.76363
ABHD6 abhydrolase domain containing 6 3.74962
MVP major vault protein 3.73507
GATA3 GATA binding protein 3 3.71203
TXNRD1 thioredoxin reductase 1 3.6814
DYNLT3 dynein, light chain, Tctex-type 3 3.61936
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.45006
NPDC1 neural proliferation, differentiation and control, 1 3.36316
ALDOC aldolase C, fructose-bisphosphate 3.35983
PNKP polynucleotide kinase 3'-phosphatase 3.34101
CDPF1 cysteine-rich, DPF motif domain containing 1 3.27983
NANOS3 nanos homolog 3 (Drosophila) 3.26999
ZFP36 ZFP36 ring finger protein 3.23344
SQOR sulfide quinone oxidoreductase 3.22273
TIMP2 TIMP metallopeptidase inhibitor 2 3.2054
PLSCR1 phospholipid scramblase 1 3.20314
SQSTM1 sequestosome 1 3.07639
LCN2 lipocalin 2 3.00253
GPER1 G protein-coupled estrogen receptor 1 2.99488
LYN LYN proto-oncogene, Src family tyrosine kinase 2.96792
IL1B interleukin 1, beta 2.7885
IGFBP3 insulin-like growth factor binding protein 3 2.70811
PTBP2 polypyrimidine tract binding protein 2 2.70121
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.65109
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.65027
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.62786
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.54643
AKR1C3 aldo-keto reductase family 1, member C3 2.52768
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.51827
AMDHD2 amidohydrolase domain containing 2 2.50628
JADE2 jade family PHD finger 2 2.50474
LRP10 low density lipoprotein receptor-related protein 10 2.50286
MAST2 microtubule associated serine/threonine kinase 2 2.46346
DENND4A DENN/MADD domain containing 4A 2.44255
CIAO3 cytosolic iron-sulfur assembly component 3 2.43459
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.42814
PHOX2A paired-like homeobox 2a 2.42506
INPP1 inositol polyphosphate-1-phosphatase 2.42505
TRIM13 tripartite motif containing 13 2.41891
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.39338
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 2.3541
TFDP3 transcription factor Dp family, member 3 2.3443
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.30481
PGPEP1 pyroglutamyl-peptidase I 2.29991
FCHO1 FCH domain only 1 2.29842
UBQLN2 ubiquilin 2 2.29296
RRAS related RAS viral (r-ras) oncogene homolog 2.27443
DRC4 dynein regulatory complex subunit 4 2.26944
ADGRE5 adhesion G protein-coupled receptor E5 2.26753
SIN3B SIN3 transcription regulator family member B 2.24711
TXNL4B thioredoxin-like 4B 2.2464
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.22543
PRSS3 protease, serine, 3 2.22505
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.2249
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.22478
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.22182
ARHGAP12 Rho GTPase activating protein 12 2.17731
SKIC2 SKI2 subunit of superkiller complex 2.16836
RALB v-ral simian leukemia viral oncogene homolog B 2.15167
MYLK myosin light chain kinase 2.14608
LSR lipolysis stimulated lipoprotein receptor 2.14229
STXBP3 syntaxin binding protein 3 2.12156
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 2.12079
DYNC2I1 dynein 2 intermediate chain 1 2.10178
FOSL1 FOS-like antigen 1 2.07744
ERBB4 erb-b2 receptor tyrosine kinase 4 2.07313
GLRX glutaredoxin (thioltransferase) 2.07119
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.06567
ZNF248 zinc finger protein 248 2.05868
GRB10 growth factor receptor-bound protein 10 2.0445
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 2.04184
ZNF589 zinc finger protein 589 2.03532
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.0348
SEPTIN2 septin 2 2.0161
CXCL2 chemokine (C-X-C motif) ligand 2 2.01602

decreased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 -9.76377
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -6.93629
ISOC1 isochorismatase domain containing 1 -6.52215
TLCD3A TLC domain containing 3A -6.30421
MAPK13 mitogen-activated protein kinase 13 -6.09588
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.7048
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.45444
CDC20 cell division cycle 20 -4.63288
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.85639
CDK1 cyclin-dependent kinase 1 -3.79171
FBXL12 F-box and leucine-rich repeat protein 12 -3.78992
CCNB1 cyclin B1 -3.77539
ZNF586 zinc finger protein 586 -3.60343
ACAA1 acetyl-CoA acyltransferase 1 -3.55253
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.52157
ICAM3 intercellular adhesion molecule 3 -3.42819
GOLT1B golgi transport 1B -3.40182
HMG20B high mobility group 20B -3.32213
ZW10 zw10 kinetochore protein -3.31769
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.28156
RPIA ribose 5-phosphate isomerase A -3.24282
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.2301
CHEK1 checkpoint kinase 1 -3.13722
PSRC1 proline/serine-rich coiled-coil 1 -3.13698
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.02942
ADI1 acireductone dioxygenase 1 -2.99758
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.90422
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.84229
PLK1 polo-like kinase 1 -2.82925
RBM34 RNA binding motif protein 34 -2.75116
GLOD4 glyoxalase domain containing 4 -2.71005
AURKB aurora kinase B -2.67217
NVL nuclear VCP-like -2.65232
UBE2C ubiquitin-conjugating enzyme E2C -2.6496
CCNA2 cyclin A2 -2.58667
HEATR1 HEAT repeat containing 1 -2.5847
DBF4 DBF4 zinc finger -2.57877
WASHC4 WASH complex subunit 4 -2.53084
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.50509
TOR1A torsin family 1, member A (torsin A) -2.48616
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.45136
TOP2A topoisomerase (DNA) II alpha 170kDa -2.43111
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.41962
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.40559
NRIP1 nuclear receptor interacting protein 1 -2.37184
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.33561
MLEC malectin -2.29094
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.28916
TENT5C terminal nucleotidyltransferase 5C -2.24165
DERL1 derlin 1 -2.2084
CCDC86 coiled-coil domain containing 86 -2.17108
SH3D19 SH3 domain containing 19 -2.16094
MTFR1 mitochondrial fission regulator 1 -2.15629
DUSP14 dual specificity phosphatase 14 -2.14538
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.14286
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 -2.1377
THOP1 thimet oligopeptidase 1 -2.1047
S100A7 S100 calcium binding protein A7 -2.07784
COCH cochlin -2.07502
HADH hydroxyacyl-CoA dehydrogenase -2.07482
MRPS16 mitochondrial ribosomal protein S16 -2.07405
MELK maternal embryonic leucine zipper kinase -2.06278
NFYB nuclear transcription factor Y, beta -2.04594
HACD2 3-hydroxyacyl-CoA dehydratase 2 -2.02266
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.01441