CRCGN014_HEPG2_24H:D03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone 41.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

542 genes differentially expressed following the CRCGN014_HEPG2_24H:D03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MSRA methionine sulfoxide reductase A 9.30177
HEBP1 heme binding protein 1 8.89791
FOS FBJ murine osteosarcoma viral oncogene homolog 6.82785
LCN2 lipocalin 2 6.51311
GADD45B growth arrest and DNA-damage-inducible, beta 6.43327
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.34717
CIAO3 cytosolic iron-sulfur assembly component 3 6.34285
ATP11B ATPase, class VI, type 11B 5.65554
CXCR4 chemokine (C-X-C motif) receptor 4 5.29182
SHB Src homology 2 domain containing adaptor protein B 5.18357
ALAS1 5'-aminolevulinate synthase 1 5.12312
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 5.11058
MMP2 matrix metallopeptidase 2 4.94014
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 4.7796
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.77849
ZFP36 ZFP36 ring finger protein 4.6125
GHR growth hormone receptor 4.52417
UBE2L6 ubiquitin-conjugating enzyme E2L 6 4.49457
TENT4A terminal nucleotidyltransferase 4A 4.43414
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 4.41305
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.3563
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 4.29079
DDIT4 DNA-damage-inducible transcript 4 4.22102
SMIM40 small integral membrane protein 40 4.18343
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.15441
MAP7 microtubule-associated protein 7 4.05197
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.03719
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 4.01637
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 3.86877
IL1B interleukin 1, beta 3.84941
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 3.82863
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.82545
SYNE2 spectrin repeat containing, nuclear envelope 2 3.81098
BLNK B-cell linker 3.78049
H2BC21 H2B clustered histone 21 3.76542
BAMBI BMP and activin membrane-bound inhibitor 3.76199
FZD1 frizzled class receptor 1 3.75271
GADD45A growth arrest and DNA-damage-inducible, alpha 3.67386
IER3 immediate early response 3 3.63722
HSPB1 heat shock 27kDa protein 1 3.57289
TMEM109 transmembrane protein 109 3.53399
H2BC12 H2B clustered histone 12 3.51307
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.49828
TSC22D3 TSC22 domain family, member 3 3.46358
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.42331
PPDPF pancreatic progenitor cell differentiation and proliferation factor 3.41931
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 3.41607
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.41383
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 3.41352
PTPRK protein tyrosine phosphatase, receptor type, K 3.35384
FAIM Fas apoptotic inhibitory molecule 3.34709
CAPN1 calpain 1, (mu/I) large subunit 3.34549
GPC1 glypican 1 3.3143
NVL nuclear VCP-like 3.31186
IFNAR1 interferon (alpha, beta and omega) receptor 1 3.30583
CTSD cathepsin D 3.28287
HTRA1 HtrA serine peptidase 1 3.27355
NOTCH1 notch 1 3.23635
JUN jun proto-oncogene 3.22098
PTMS parathymosin 3.21079
TCEA2 transcription elongation factor A (SII), 2 3.20979
RTL8A retrotransposon Gag like 8A 3.20759
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 3.19905
RAB21 RAB21, member RAS oncogene family 3.1799
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.17561
TIMP2 TIMP metallopeptidase inhibitor 2 3.16726
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 3.15272
DIPK1A divergent protein kinase domain 1A 3.13036
DPYSL3 dihydropyrimidinase-like 3 3.04313
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.01401
TRAPPC6A trafficking protein particle complex 6A 2.97809
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.93595
AMDHD2 amidohydrolase domain containing 2 2.93041
HAO2 hydroxyacid oxidase 2 (long chain) 2.92644
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.92044
AIRIM AFG2 interacting ribosome maturation factor 2.90136
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 2.89123
PRKX protein kinase, X-linked 2.88166
HSPA1A heat shock 70kDa protein 1A 2.86631
EGR1 early growth response 1 2.82192
PRR15L proline rich 15-like 2.80117
PLGLB2 plasminogen-like B2 2.78621
ALDOC aldolase C, fructose-bisphosphate 2.78195
HAT1 histone acetyltransferase 1 2.77668
SCRN1 secernin 1 2.7565
ZNF362 zinc finger protein 362 2.74996
H1-2 H1.2 linker histone, cluster member 2.7387
SOX2 SRY (sex determining region Y)-box 2 2.73168
IPO13 importin 13 2.72876
STAP1 signal transducing adaptor family member 1 2.72867
RGS16 regulator of G-protein signaling 16 2.72322
HTATSF1 HIV-1 Tat specific factor 1 2.70846
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.70325
ADGRG1 adhesion G protein-coupled receptor G1 2.69907
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 2.69633
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 2.67964
CTNND1 catenin (cadherin-associated protein), delta 1 2.66822
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.66612
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 2.64725
TESK1 testis-specific kinase 1 2.64619
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 2.63637
NT5E 5'-nucleotidase, ecto (CD73) 2.62016
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 2.6144
HSPA1B heat shock 70kDa protein 1B 2.61167
FCHO1 FCH domain only 1 2.61112
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 2.60274
ZNF395 zinc finger protein 395 2.59883
ARL4C ADP-ribosylation factor-like 4C 2.59771
RBM8A RNA binding motif protein 8A 2.59598
LYN LYN proto-oncogene, Src family tyrosine kinase 2.58615
BHMT betaine--homocysteine S-methyltransferase 2.57318
RAB43 RAB43, member RAS oncogene family 2.57137
EN1 engrailed homeobox 1 2.56326
HABP2 hyaluronan binding protein 2 2.54407
CD200R1 CD200 receptor 1 2.53259
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 2.53055
TERT telomerase reverse transcriptase 2.52429
EDN1 endothelin 1 2.5218
ALDOB aldolase B, fructose-bisphosphate 2.52171
MBTD1 mbt domain containing 1 2.51507
KDM8 lysine (K)-specific demethylase 8 2.51126
MSI1 musashi RNA-binding protein 1 2.4907
RAI14 retinoic acid induced 14 2.48367
INSRR insulin receptor-related receptor 2.48152
FAM234B family with sequence similarity 234 member B 2.47973
PRAMEF10 PRAME family member 10 2.47937
PTPRC protein tyrosine phosphatase, receptor type, C 2.47315
SBDS Shwachman-Bodian-Diamond syndrome 2.47201
CEP72 centrosomal protein 72kDa 2.47195
AFM afamin 2.46797
PLG plasminogen 2.46785
CNOT3 CCR4-NOT transcription complex, subunit 3 2.46717
ERCC5 excision repair cross-complementation group 5 2.46555
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.46302
F9 coagulation factor IX 2.45898
ADGRB2 adhesion G protein-coupled receptor B2 2.45819
LDOC1 leucine zipper, down-regulated in cancer 1 2.45769
VAC14 Vac14 homolog (S. cerevisiae) 2.44245
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.44039
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 2.43662
MYL9 myosin, light chain 9, regulatory 2.42747
FAM246A family with sequence similarity 246 member A 2.42656
ONECUT1 one cut homeobox 1 2.41948
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.41812
WASHC5 WASH complex subunit 5 2.41569
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.40838
EZR ezrin 2.40706
TP53 tumor protein p53 2.40584
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.39874
SATB1 SATB homeobox 1 2.39676
SNRPA small nuclear ribonucleoprotein polypeptide A 2.39519
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 2.37861
FETUB fetuin B 2.37249
FGFR2 fibroblast growth factor receptor 2 2.36843
ARHGAP8 Rho GTPase activating protein 8 2.36636
APCS amyloid P component, serum 2.36593
ECM1 extracellular matrix protein 1 2.36196
RNLS renalase, FAD-dependent amine oxidase 2.36164
PTH1R parathyroid hormone 1 receptor 2.34939
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 2.3436
CNGA1 cyclic nucleotide gated channel alpha 1 2.33907
CCDC25 coiled-coil domain containing 25 2.33806
CA7 carbonic anhydrase VII 2.33688
SDC1 syndecan 1 2.33163
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 2.32329
NUP93 nucleoporin 93kDa 2.32113
KCNA10 potassium channel, voltage gated shaker related subfamily A, member 10 2.31884
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 2.31883
CARMIL1 capping protein regulator and myosin 1 linker 1 2.31864
THSD4 thrombospondin, type I, domain containing 4 2.30389
DPYS dihydropyrimidinase 2.30127
TEX14 testis expressed 14 2.29833
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 2.29818
PTPN14 protein tyrosine phosphatase, non-receptor type 14 2.2968
GRB10 growth factor receptor-bound protein 10 2.29333
STMN3 stathmin-like 3 2.29184
TES testin LIM domain protein 2.28781
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.27905
ZG16 zymogen granule protein 16 2.27863
RIDA reactive intermediate imine deaminase A homolog 2.26602
HUNK hormonally up-regulated Neu-associated kinase 2.26342
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.25924
MAMLD1 mastermind-like domain containing 1 2.2517
TMEM40 transmembrane protein 40 2.25151
CRMP1 collapsin response mediator protein 1 2.24762
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 2.24667
NCAN neurocan 2.24231
USP53 ubiquitin specific peptidase 53 2.23863
RIPOR1 RHO family interacting cell polarization regulator 1 2.23504
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 2.23331
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.229
SCRN3 secernin 3 2.22892
EFHD1 EF-hand domain family, member D1 2.22849
STK10 serine/threonine kinase 10 2.22344
VGLL1 vestigial-like family member 1 2.22279
ASIC1 acid sensing (proton gated) ion channel 1 2.22105
KNG1 kininogen 1 2.21603
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 2.21488
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 2.21174
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.21116
ANGPTL3 angiopoietin-like 3 2.21058
PSENEN presenilin enhancer gamma secretase subunit 2.20574
RGCC regulator of cell cycle 2.20544
RASA3 RAS p21 protein activator 3 2.19975
CRABP2 cellular retinoic acid binding protein 2 2.19794
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 2.19752
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 2.19498
BAD BCL2-associated agonist of cell death 2.19067
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.18869
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 2.18848
CCL2 chemokine (C-C motif) ligand 2 2.186
OXCT1 3-oxoacid CoA transferase 1 2.18454
CD72 CD72 molecule 2.18426
ATG10 autophagy related 10 2.18339
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 2.18219
H2AJ H2A.J histone 2.18125
FCRLB Fc receptor-like B 2.17876
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.17742
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 2.17722
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.17554
FGF18 fibroblast growth factor 18 2.17499
RB1 retinoblastoma 1 2.17419
FGF23 fibroblast growth factor 23 2.17258
SMG9 SMG9 nonsense mediated mRNA decay factor 2.16721
KIRREL1 kirre like nephrin family adhesion molecule 1 2.16654
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.16193
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 2.15962
RND1 Rho family GTPase 1 2.15926
BNC1 basonuclin 1 2.15766
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 2.15677
OPRK1 opioid receptor, kappa 1 2.15524
ZHX3 zinc fingers and homeoboxes 3 2.15372
EYA3 EYA transcriptional coactivator and phosphatase 3 2.15101
PTK6 protein tyrosine kinase 6 2.15012
ATP2A3 ATPase, Ca++ transporting, ubiquitous 2.14924
COL8A2 collagen, type VIII, alpha 2 2.14904
EPX eosinophil peroxidase 2.14766
PROP1 PROP paired-like homeobox 1 2.14451
TBXA2R thromboxane A2 receptor 2.14173
GPR18 G protein-coupled receptor 18 2.1371
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.1361
HSFX2 heat shock transcription factor family, X linked 2 2.13352
CAMK1D calcium/calmodulin-dependent protein kinase ID 2.13328
H2BC5 H2B clustered histone 5 2.13074
IFT54 intraflagellar transport 54 2.13009
TEX13A testis expressed 13A 2.12915
SLITRK2 SLIT and NTRK-like family, member 2 2.12468
RARG retinoic acid receptor, gamma 2.1244
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 2.12378
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 2.12282
SYNGAP1 synaptic Ras GTPase activating protein 1 2.12011
DENND1B DENN/MADD domain containing 1B 2.1176
WRNIP1 Werner helicase interacting protein 1 2.11678
NMU neuromedin U 2.11537
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 2.11467
PLA2G2F phospholipase A2, group IIF 2.11192
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 2.11023
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.10797
MYH4 myosin, heavy chain 4, skeletal muscle 2.10632
OR10H3 olfactory receptor, family 10, subfamily H, member 3 2.10538
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 2.10509
ZBED2 zinc finger, BED-type containing 2 2.10434
MKRN3 makorin ring finger protein 3 2.10337
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.10088
ADRB2 adrenoceptor beta 2, surface 2.10054
CD24 CD24 molecule 2.09868
ERI3 ERI1 exoribonuclease family member 3 2.09767
CLPTM1 cleft lip and palate associated transmembrane protein 1 2.09711
PDE9A phosphodiesterase 9A 2.09538
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.09403
MPC2 mitochondrial pyruvate carrier 2 2.09355
AMELY amelogenin, Y-linked 2.0899
BICDL1 BICD family like cargo adaptor 1 2.08877
ADAM28 ADAM metallopeptidase domain 28 2.08757
SLC4A3 solute carrier family 4 (anion exchanger), member 3 2.08668
ZFR2 zinc finger RNA binding protein 2 2.08004
IGFBP3 insulin-like growth factor binding protein 3 2.0798
CORO1A coronin, actin binding protein, 1A 2.07943
CEMP1 cementum protein 1 2.07838
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 2.07794
IFT38 intraflagellar transport 38 2.07788
LRRK1 leucine-rich repeat kinase 1 2.0768
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 2.07598
MMP24OS MMP24 opposite strand 2.07556
TAS2R9 taste receptor, type 2, member 9 2.07387
ZNF331 zinc finger protein 331 2.06982
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.06695
EXD3 exonuclease 3'-5' domain containing 3 2.06403
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2.06311
PATJ PATJ crumbs cell polarity complex component 2.06035
NIPSNAP3B nipsnap homolog 3B (C. elegans) 2.06008
FKBP4 FK506 binding protein 4, 59kDa 2.05975
NHLH2 nescient helix loop helix 2 2.05935
PDE5A phosphodiesterase 5A, cGMP-specific 2.05771
KIAA0408 KIAA0408 2.05585
AMIGO2 adhesion molecule with Ig-like domain 2 2.05303
AEBP1 AE binding protein 1 2.05245
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 2.05115
TMEM158 transmembrane protein 158 (gene/pseudogene) 2.04897
THY1 Thy-1 cell surface antigen 2.04714
CLDN14 claudin 14 2.04028
SYT13 synaptotagmin XIII 2.03934
IGFBP5 insulin-like growth factor binding protein 5 2.03504
PON1 paraoxonase 1 2.03335
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 2.03263
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 2.02664
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.02582
OR10H1 olfactory receptor, family 10, subfamily H, member 1 2.02567
SCN4A sodium channel, voltage gated, type IV alpha subunit 2.02525
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 2.02373
CDK5RAP2 CDK5 regulatory subunit associated protein 2 2.02335
AP3B2 adaptor-related protein complex 3, beta 2 subunit 2.02274
UMOD uromodulin 2.02216
BTK Bruton agammaglobulinemia tyrosine kinase 2.02032
IKZF2 IKAROS family zinc finger 2 (Helios) 2.01792
MOSPD3 motile sperm domain containing 3 2.01732
CAB39L calcium binding protein 39-like 2.01622
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 2.01441
MRPL18 mitochondrial ribosomal protein L18 2.01341
MTERF3 mitochondrial transcription termination factor 3 2.0134
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 2.01164
GHRH growth hormone releasing hormone 2.00919
ADRA2B adrenoceptor alpha 2B 2.0087
L1CAM L1 cell adhesion molecule 2.0071
FEZF2 FEZ family zinc finger 2 2.00467
GPR12 G protein-coupled receptor 12 2.00454
BIRC7 baculoviral IAP repeat containing 7 2.00357
TBX6 T-box 6 2.00116
SOCS2 suppressor of cytokine signaling 2 2.00113
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 2.00083
TPD52-MRPS28 TPD52-MRPS28 readthrough 2.00068

decreased expression

Symbol Name Standardized Value
FASTKD5 FAST kinase domains 5 -9.85488
MYC v-myc avian myelocytomatosis viral oncogene homolog -8.83838
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -8.82856
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.80908
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -6.65714
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.57942
LDHD lactate dehydrogenase D -6.38007
NCK1 NCK adaptor protein 1 -5.78968
BLCAP bladder cancer associated protein -5.64787
TLCD3A TLC domain containing 3A -5.58946
C2CD5 C2 calcium-dependent domain containing 5 -5.55922
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.34282
GTPBP8 GTP-binding protein 8 (putative) -5.32604
NISCH nischarin -5.26235
TRIB1 tribbles pseudokinase 1 -5.23871
B4GAT1 beta-1,4-glucuronyltransferase 1 -4.90079
TOP2A topoisomerase (DNA) II alpha 170kDa -4.85365
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -4.84722
PCCB propionyl CoA carboxylase, beta polypeptide -4.84521
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -4.73553
MRPS2 mitochondrial ribosomal protein S2 -4.53286
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.43852
RFC2 replication factor C (activator 1) 2, 40kDa -4.36255
KEAP1 kelch-like ECH-associated protein 1 -4.29349
INTS3 integrator complex subunit 3 -4.28522
AKAP8 A kinase (PRKA) anchor protein 8 -4.26833
CDK1 cyclin-dependent kinase 1 -4.13939
ADO 2-aminoethanethiol (cysteamine) dioxygenase -4.06976
RBM15B RNA binding motif protein 15B -4.05386
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.96785
HOXA5 homeobox A5 -3.8183
CD320 CD320 molecule -3.79567
CDKN2A cyclin-dependent kinase inhibitor 2A -3.7282
DUSP6 dual specificity phosphatase 6 -3.71634
LBR lamin B receptor -3.6989
KDM3A lysine (K)-specific demethylase 3A -3.61594
THAP11 THAP domain containing 11 -3.53076
ADAM10 ADAM metallopeptidase domain 10 -3.51319
TXLNA taxilin alpha -3.47557
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -3.42203
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -3.41722
TCERG1 transcription elongation regulator 1 -3.34487
CASC3 cancer susceptibility candidate 3 -3.27295
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -3.26084
NNT nicotinamide nucleotide transhydrogenase -3.21091
CASP3 caspase 3, apoptosis-related cysteine peptidase -3.20933
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -3.17937
SPAG4 sperm associated antigen 4 -3.13998
NUP85 nucleoporin 85kDa -3.12345
VGLL4 vestigial-like family member 4 -3.11386
DUSP14 dual specificity phosphatase 14 -3.11126
CYTH1 cytohesin 1 -3.10523
SKIC2 SKI2 subunit of superkiller complex -3.05014
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -3.02749
KIAA0232 KIAA0232 -2.97567
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.95971
RBM7 RNA binding motif protein 7 -2.93827
SUCO SUN domain containing ossification factor -2.92289
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa -2.90121
NKAPD1 NKAP domain containing 1 -2.89348
ADI1 acireductone dioxygenase 1 -2.89327
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -2.86534
BTBD3 BTB (POZ) domain containing 3 -2.86447
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.85798
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.85739
AFG3L2 AFG3-like AAA ATPase 2 -2.85462
CGRRF1 cell growth regulator with ring finger domain 1 -2.85318
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.83058
GABPB1 GA binding protein transcription factor, beta subunit 1 -2.80675
HAPSTR1 HUWE1 associated protein modifying stress responses -2.79515
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.78776
GOLGA7 golgin A7 -2.78566
CAPN7 calpain 7 -2.73887
TATDN2 TatD DNase domain containing 2 -2.73737
TMEM33 transmembrane protein 33 -2.73655
THAP12 THAP domain containing 12 -2.72093
PRKCD protein kinase C, delta -2.71975
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -2.70724
ZNF106 zinc finger protein 106 -2.69505
RBM14-RBM4 RBM14-RBM4 readthrough -2.68916
ZMIZ1 zinc finger, MIZ-type containing 1 -2.68328
NRIP1 nuclear receptor interacting protein 1 -2.67684
TMEM168 transmembrane protein 168 -2.65035
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -2.64799
TMEM165 transmembrane protein 165 -2.63849
TM9SF3 transmembrane 9 superfamily member 3 -2.63742
MED28 mediator complex subunit 28 -2.63736
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) -2.63392
ENDOG endonuclease G -2.63265
SP3 Sp3 transcription factor -2.62538
PRUNE1 prune exopolyphosphatase 1 -2.59813
RNF4 ring finger protein 4 -2.59579
ZDHHC6 zinc finger, DHHC-type containing 6 -2.58901
TCTN1 tectonic family member 1 -2.58434
NLRP2B NLR family pyrin domain containing 2B -2.55897
BTBD1 BTB (POZ) domain containing 1 -2.55496
ASDURF ASNSD1 upstream open reading frame -2.55149
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -2.54383
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 -2.53836
EMID1 EMI domain containing 1 -2.53827
MARCKSL1 MARCKS-like 1 -2.53597
MGA MGA, MAX dimerization protein -2.53513
PSRC1 proline/serine-rich coiled-coil 1 -2.53181
MAT2A methionine adenosyltransferase II, alpha -2.52289
DOLK dolichol kinase -2.51391
PCNA proliferating cell nuclear antigen -2.51298
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.50244
MAPK6 mitogen-activated protein kinase 6 -2.50164
CCNA2 cyclin A2 -2.49675
RBM15 RNA binding motif protein 15 -2.49478
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 -2.49327
TWF2 twinfilin actin binding protein 2 -2.48498
ZNF318 zinc finger protein 318 -2.48477
ATMIN ATM interactor -2.48359
MELK maternal embryonic leucine zipper kinase -2.47589
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.46402
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) -2.44917
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.44199
MYLK myosin light chain kinase -2.40043
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.38833
SNIP1 Smad nuclear interacting protein 1 -2.35999
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 -2.35857
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.35561
MUL1 mitochondrial E3 ubiquitin protein ligase 1 -2.35397
GRSF1 G-rich RNA sequence binding factor 1 -2.34478
BST2 bone marrow stromal cell antigen 2 -2.33153
ZW10 zw10 kinetochore protein -2.3282
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) -2.32741
FRYL FRY-like -2.32185
ANKRD17 ankyrin repeat domain 17 -2.32009
SETX senataxin -2.31232
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.30516
PRPF38B pre-mRNA processing factor 38B -2.30426
NPTN neuroplastin -2.30174
CENPN centromere protein N -2.30145
GOLT1B golgi transport 1B -2.29291
SEC23A Sec23 homolog A (S. cerevisiae) -2.2925
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') -2.28111
SYNGR3 synaptogyrin 3 -2.28079
TMED1 transmembrane emp24 protein transport domain containing 1 -2.27356
LOC124907090 ankyrin repeat domain-containing protein SOWAHC-like -2.26849
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -2.2681
NFIL3 nuclear factor, interleukin 3 regulated -2.26627
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -2.25866
SACS sacsin molecular chaperone -2.25443
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 -2.24825
IFT88 intraflagellar transport 88 -2.24332
MAP2K4 mitogen-activated protein kinase kinase 4 -2.24097
MIS12 MIS12 kinetochore complex component -2.22305
TMX1 thioredoxin-related transmembrane protein 1 -2.22272
UBE3C ubiquitin protein ligase E3C -2.1992
AKAP11 A kinase (PRKA) anchor protein 11 -2.1961
TOR1A torsin family 1, member A (torsin A) -2.19609
STARD13 StAR-related lipid transfer (START) domain containing 13 -2.19589
SIRAL2 SIR2 antiphage like 2 -2.19399
HMGXB4 HMG box domain containing 4 -2.19392
RBM12 RNA binding motif protein 12 -2.19303
TMEM115 transmembrane protein 115 -2.19228
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.19084
ARGLU1 arginine and glutamate rich 1 -2.18438
NEK4 NIMA-related kinase 4 -2.18281
HMG20B high mobility group 20B -2.17847
CDK6 cyclin-dependent kinase 6 -2.17708
DENND4B DENN/MADD domain containing 4B -2.16951
KLHL9 kelch-like family member 9 -2.16865
NPR2 natriuretic peptide receptor 2 -2.16227
GAS7 growth arrest-specific 7 -2.15432
BCL10 B-cell CLL/lymphoma 10 -2.15151
RBBP4 retinoblastoma binding protein 4 -2.1492
ZFYVE16 zinc finger, FYVE domain containing 16 -2.1491
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -2.1471
KLHDC2 kelch domain containing 2 -2.14346
SLIRP SRA stem-loop interacting RNA binding protein -2.14264
ELF2 E74-like factor 2 (ets domain transcription factor) -2.13729
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.13725
PLP1 proteolipid protein 1 -2.13693
ZNF518A zinc finger protein 518A -2.13026
TRIB3 tribbles pseudokinase 3 -2.10837
IQGAP2 IQ motif containing GTPase activating protein 2 -2.10763
ACBD3 acyl-CoA binding domain containing 3 -2.10234
NUP54 nucleoporin 54kDa -2.0963
ARID4B AT rich interactive domain 4B (RBP1-like) -2.09571
PDIA2 protein disulfide isomerase family A, member 2 -2.09002
UBIAD1 UbiA prenyltransferase domain containing 1 -2.08995
CRYZ crystallin, zeta (quinone reductase) -2.08483
TASOR2 transcription activation suppressor family member 2 -2.0848
SMG8 SMG8 nonsense mediated mRNA decay factor -2.08394
RGS2 regulator of G-protein signaling 2 -2.08282
SELENOT selenoprotein T -2.0777
DCK deoxycytidine kinase -2.07674
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase -2.07075
SPPL2A signal peptide peptidase like 2A -2.06997
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 -2.06868
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -2.06798
TM9SF2 transmembrane 9 superfamily member 2 -2.06288
GDE1 glycerophosphodiester phosphodiesterase 1 -2.0627
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -2.05857
ZNF140 zinc finger protein 140 -2.05736
SSUH2 ssu-2 homolog (C. elegans) -2.05274
ALG6 ALG6, alpha-1,3-glucosyltransferase -2.04521
CHSY1 chondroitin sulfate synthase 1 -2.04451
DLAT dihydrolipoamide S-acetyltransferase -2.04298
SCAF8 SR-related CTD-associated factor 8 -2.03975
GGNBP2 gametogenetin binding protein 2 -2.03525
FBXO34 F-box protein 34 -2.03227
RELN reelin -2.01677
ZCCHC24 zinc finger, CCHC domain containing 24 -2.01524
FAT1 FAT atypical cadherin 1 -2.01506
PANX1 pannexin 1 -2.01379
RBM4 RNA binding motif protein 4 -2.00918
PLAGL2 pleiomorphic adenoma gene-like 2 -2.00896