| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | tretinoin 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
| Downloads & Tools |
80 genes differentially expressed following the CRCGN014_HEPG2_24H:D04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 6.89463 |
| HOXA5 | homeobox A5 | 5.97989 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 5.80658 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 5.63212 |
| DDIT4 | DNA-damage-inducible transcript 4 | 4.79328 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | 4.05299 |
| CHMP6 | charged multivesicular body protein 6 | 3.92449 |
| LCN2 | lipocalin 2 | 3.9096 |
| UBQLN2 | ubiquilin 2 | 3.80473 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.80079 |
| E2F2 | E2F transcription factor 2 | 3.71858 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 3.56733 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.38318 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 3.2698 |
| TRIB3 | tribbles pseudokinase 3 | 3.2113 |
| MSRA | methionine sulfoxide reductase A | 3.10245 |
| AMDHD2 | amidohydrolase domain containing 2 | 3.06154 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 2.97356 |
| TATDN2 | TatD DNase domain containing 2 | 2.93449 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 2.88612 |
| MICALL1 | MICAL-like 1 | 2.86434 |
| STK10 | serine/threonine kinase 10 | 2.85414 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 2.85315 |
| MAP7 | microtubule-associated protein 7 | 2.83105 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 2.71144 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.66826 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 2.64471 |
| ECH1 | enoyl CoA hydratase 1, peroxisomal | 2.5306 |
| PDLIM1 | PDZ and LIM domain 1 | 2.45531 |
| PARP2 | poly (ADP-ribose) polymerase 2 | 2.43796 |
| SQOR | sulfide quinone oxidoreductase | 2.42032 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 2.34237 |
| ABHD4 | abhydrolase domain containing 4 | 2.30351 |
| MEST | mesoderm specific transcript | 2.28419 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 2.27721 |
| HEBP1 | heme binding protein 1 | 2.19297 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 2.08308 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.05435 |
| SHMT1 | serine hydroxymethyltransferase 1 (soluble) | 2.02891 |
| GFI1B | growth factor independent 1B transcription repressor | 2.01647 |
| PHGDH | phosphoglycerate dehydrogenase | 2.00868 |
| TGM1 | transglutaminase 1 | 2.00204 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -6.74172 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -5.35772 |
| MAPK13 | mitogen-activated protein kinase 13 | -4.46323 |
| ZNF586 | zinc finger protein 586 | -4.31549 |
| DUSP6 | dual specificity phosphatase 6 | -3.90583 |
| USP6NL | USP6 N-terminal like | -3.69518 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | -3.44433 |
| TLR4 | toll-like receptor 4 | -3.30577 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -2.94452 |
| CDC25B | cell division cycle 25B | -2.85895 |
| VAT1 | vesicle amine transport 1 | -2.84348 |
| THAP11 | THAP domain containing 11 | -2.83004 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -2.79151 |
| PLS1 | plastin 1 | -2.77921 |
| EDN1 | endothelin 1 | -2.6275 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | -2.47686 |
| SNX11 | sorting nexin 11 | -2.4751 |
| LYPLA1 | lysophospholipase I | -2.46517 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -2.41877 |
| KBTBD2 | kelch repeat and BTB (POZ) domain containing 2 | -2.38139 |
| S100A4 | S100 calcium binding protein A4 | -2.36597 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -2.35559 |
| MVP | major vault protein | -2.35438 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -2.31032 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.26807 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -2.26219 |
| FASTKD5 | FAST kinase domains 5 | -2.25586 |
| IER3 | immediate early response 3 | -2.18841 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -2.18359 |
| TNIP1 | TNFAIP3 interacting protein 1 | -2.16669 |
| GLRX | glutaredoxin (thioltransferase) | -2.15558 |
| ZNF223 | zinc finger protein 223 | -2.13266 |
| DPYD | dihydropyrimidine dehydrogenase | -2.09849 |
| MTFR1 | mitochondrial fission regulator 1 | -2.04983 |
| ZNF574 | zinc finger protein 574 | -2.04977 |
| EGF | epidermal growth factor | -2.0482 |
| ND5 | NADH dehydrogenase subunit 5 | -2.02178 |
| FAT1 | FAT atypical cadherin 1 | -2.01015 |
