CRCGN014_HEPG2_24H:D05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pentachlorophenol 39.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

320 genes differentially expressed following the CRCGN014_HEPG2_24H:D05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 6.53519
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.50391
TIMP2 TIMP metallopeptidase inhibitor 2 6.29136
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.22177
PEX11A peroxisomal biogenesis factor 11 alpha 5.92869
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.91072
KIFBP kinesin family binding protein 5.88174
BZW2 basic leucine zipper and W2 domains 2 5.77836
STAP2 signal transducing adaptor family member 2 5.74069
SQOR sulfide quinone oxidoreductase 5.6068
PPARG peroxisome proliferator-activated receptor gamma 5.37955
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 5.34993
CHMP6 charged multivesicular body protein 6 5.26061
CNPY3 canopy FGF signaling regulator 3 5.17016
PLSCR1 phospholipid scramblase 1 5.11448
ZFP36 ZFP36 ring finger protein 5.10512
PFKL phosphofructokinase, liver 4.75706
CYTH1 cytohesin 1 4.48189
CARMIL1 capping protein regulator and myosin 1 linker 1 4.41503
SOCS2 suppressor of cytokine signaling 2 4.31284
C2CD2 C2 calcium-dependent domain containing 2 4.30745
ADGRE5 adhesion G protein-coupled receptor E5 4.27715
MVP major vault protein 4.2353
CGRRF1 cell growth regulator with ring finger domain 1 4.05829
NANOS3 nanos homolog 3 (Drosophila) 3.90339
CRYZ crystallin, zeta (quinone reductase) 3.80673
RAP1GAP RAP1 GTPase activating protein 3.79153
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.65504
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.64349
CCDC92 coiled-coil domain containing 92 3.6367
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.57845
GPER1 G protein-coupled estrogen receptor 1 3.44156
SNAP25 synaptosomal-associated protein, 25kDa 3.40079
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.37909
JADE2 jade family PHD finger 2 3.37896
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 3.37088
SPTAN1 spectrin, alpha, non-erythrocytic 1 3.32633
CYCS cytochrome c, somatic 3.30396
MINDY1 MINDY lysine 48 deubiquitinase 1 3.25997
RSU1 Ras suppressor protein 1 3.22751
FOSL1 FOS-like antigen 1 3.1771
GPATCH8 G patch domain containing 8 3.16222
INPP1 inositol polyphosphate-1-phosphatase 3.07742
HMOX1 heme oxygenase 1 3.01008
CAB39 calcium binding protein 39 3.00975
ATP11B ATPase, class VI, type 11B 3.00165
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.98424
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.97463
STK10 serine/threonine kinase 10 2.96154
RPP38 ribonuclease P/MRP 38kDa subunit 2.955
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.93047
CBR3 carbonyl reductase 3 2.90968
BMP4 bone morphogenetic protein 4 2.879
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.8736
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.86258
CXCL2 chemokine (C-X-C motif) ligand 2 2.84159
LSR lipolysis stimulated lipoprotein receptor 2.8251
DUSP3 dual specificity phosphatase 3 2.82206
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 2.74053
SMTN smoothelin 2.72944
MST1R macrophage stimulating 1 receptor 2.69246
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 2.68544
FBN1 fibrillin 1 2.68368
ATP13A2 ATPase type 13A2 2.68276
COL18A1 collagen, type XVIII, alpha 1 2.68212
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.67981
GLRX glutaredoxin (thioltransferase) 2.6621
BACE2 beta-site APP-cleaving enzyme 2 2.63916
DYNLT3 dynein, light chain, Tctex-type 3 2.63328
PLEC plectin 2.62517
SLC75A1 solute carrier family 75 member 1 2.62473
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.62271
STX4 syntaxin 4 2.59492
PARP12 poly (ADP-ribose) polymerase family, member 12 2.59121
EPHB2 EPH receptor B2 2.58709
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 2.57821
RALB v-ral simian leukemia viral oncogene homolog B 2.56746
MTERF3 mitochondrial transcription termination factor 3 2.55616
GLT8D2 glycosyltransferase 8 domain containing 2 2.55075
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 2.53387
TXNRD1 thioredoxin reductase 1 2.51339
ABHD4 abhydrolase domain containing 4 2.51001
ADRB2 adrenoceptor beta 2, surface 2.50446
HOXA4 homeobox A4 2.50347
INF2 inverted formin, FH2 and WH2 domain containing 2.50284
PLS1 plastin 1 2.50275
PROCR protein C receptor, endothelial 2.48868
EPN2 epsin 2 2.45973
IFI35 interferon-induced protein 35 2.45608
CTSL cathepsin L 2.43808
HDGFL3 HDGF like 3 2.433
JMJD1C jumonji domain containing 1C 2.43003
ANO10 anoctamin 10 2.42855
BAD BCL2-associated agonist of cell death 2.42691
OLFML2B olfactomedin-like 2B 2.42566
DACT1 dishevelled-binding antagonist of beta-catenin 1 2.40244
ANKRD28 ankyrin repeat domain 28 2.39292
RSBN1 round spermatid basic protein 1 2.37617
NPC1 Niemann-Pick disease, type C1 2.36589
DENND5A DENN/MADD domain containing 5A 2.36541
DMXL1 Dmx-like 1 2.35739
NOSIP nitric oxide synthase interacting protein 2.34909
FNBP1L formin binding protein 1-like 2.34845
EBF2 early B-cell factor 2 2.33943
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.32361
MMP2 matrix metallopeptidase 2 2.32295
RBM7 RNA binding motif protein 7 2.31339
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 2.31132
UGDH UDP-glucose 6-dehydrogenase 2.30071
THY1 Thy-1 cell surface antigen 2.30029
MAPK3 mitogen-activated protein kinase 3 2.29175
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.29078
YIPF3 Yip1 domain family, member 3 2.28516
CLIP2 CAP-GLY domain containing linker protein 2 2.26528
ANO1 anoctamin 1, calcium activated chloride channel 2.24652
MAST2 microtubule associated serine/threonine kinase 2 2.24168
FBXO2 F-box protein 2 2.23285
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.23094
TPRA1 transmembrane protein, adipocyte asscociated 1 2.22313
SNX24 sorting nexin 24 2.21062
CPQ carboxypeptidase Q 2.19527
LOC122526780 uncharacterized LOC122526780 2.17882
COL6A2 collagen, type VI, alpha 2 2.17658
MYOF myoferlin 2.17278
MED15 mediator complex subunit 15 2.16579
MGLL monoglyceride lipase 2.16261
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 2.16012
MX1 MX dynamin-like GTPase 1 2.14654
GOLGB1 golgin B1 2.14292
PRKCD protein kinase C, delta 2.14132
PDE8A phosphodiesterase 8A 2.14051
CUL7 cullin 7 2.13956
HLA-DRA major histocompatibility complex, class II, DR alpha 2.13914
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 2.13743
FLNB filamin B, beta 2.1314
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 2.13002
MATN2 matrilin 2 2.12535
STXBP3 syntaxin binding protein 3 2.1239
CTTN cortactin 2.11752
HSPG2 heparan sulfate proteoglycan 2 2.11225
CD34 CD34 molecule 2.10913
MYLK myosin light chain kinase 2.10844
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 2.10008
MEX3C mex-3 RNA binding family member C 2.09973
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.09713
SQSTM1 sequestosome 1 2.09216
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.08077
SPATA7 spermatogenesis associated 7 2.07136
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.06538
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 2.06509
TIAM1 T-cell lymphoma invasion and metastasis 1 2.05975
ISLR immunoglobulin superfamily containing leucine-rich repeat 2.05677
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 2.05601
THSD7A thrombospondin, type I, domain containing 7A 2.0522
CCDC86 coiled-coil domain containing 86 2.04979
TOB2 transducer of ERBB2, 2 2.04811
ISG15 ISG15 ubiquitin-like modifier 2.04242
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 2.04118
CARD10 caspase recruitment domain family, member 10 2.03452
PTBP2 polypyrimidine tract binding protein 2 2.03093
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 2.0285
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.02702
AHCYL1 adenosylhomocysteinase-like 1 2.02505
PDE1A phosphodiesterase 1A, calmodulin-dependent 2.02406
TRAK2 trafficking protein, kinesin binding 2 2.02084
KIFC3 kinesin family member C3 2.02051
NR1D2 nuclear receptor subfamily 1, group D, member 2 2.01565
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.01278
ITGB5 integrin, beta 5 2.01179
AZIN2 antizyme inhibitor 2 2.00706
AHR aryl hydrocarbon receptor 2.00167

decreased expression

Symbol Name Standardized Value
ISOC1 isochorismatase domain containing 1 -7.89027
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -6.80297
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -6.56863
TRIB3 tribbles pseudokinase 3 -6.22821
CDC20 cell division cycle 20 -5.96364
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.66268
PCNA proliferating cell nuclear antigen -5.58513
PSRC1 proline/serine-rich coiled-coil 1 -5.51657
NUP85 nucleoporin 85kDa -5.31277
ADI1 acireductone dioxygenase 1 -5.26331
MELK maternal embryonic leucine zipper kinase -4.97211
RPIA ribose 5-phosphate isomerase A -4.85674
TCTN1 tectonic family member 1 -4.68264
CDK1 cyclin-dependent kinase 1 -4.6223
CCNA2 cyclin A2 -4.47648
C5 complement component 5 -4.4751
UBE2C ubiquitin-conjugating enzyme E2C -4.35939
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.28967
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.28202
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -4.23417
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.18286
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.13922
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -4.09664
CCNB1 cyclin B1 -4.04444
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -4.01492
ZDHHC6 zinc finger, DHHC-type containing 6 -3.82557
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.72919
POLR1A polymerase (RNA) I polypeptide A, 194kDa -3.6386
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.59183
THAP11 THAP domain containing 11 -3.49459
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.4493
TCERG1 transcription elongation regulator 1 -3.43482
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -3.42419
AURKB aurora kinase B -3.40786
DPH2 DPH2 homolog (S. cerevisiae) -3.31768
TOPBP1 topoisomerase (DNA) II binding protein 1 -3.21589
RPS5 ribosomal protein S5 -3.21292
NVL nuclear VCP-like -3.21093
F9 coagulation factor IX -3.16787
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.13732
HAT1 histone acetyltransferase 1 -3.1364
PECR peroxisomal trans-2-enoyl-CoA reductase -3.09973
TMEM97 transmembrane protein 97 -3.08872
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.0487
YME1L1 YME1-like 1 ATPase -2.98662
SLC35F2 solute carrier family 35, member F2 -2.98122
PLK1 polo-like kinase 1 -2.96709
GOLT1B golgi transport 1B -2.94525
CDK4 cyclin-dependent kinase 4 -2.93885
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.93293
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.91507
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.90471
LAP3 leucine aminopeptidase 3 -2.88543
TOP2A topoisomerase (DNA) II alpha 170kDa -2.85432
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.85077
EXT1 exostosin glycosyltransferase 1 -2.7995
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.78428
MLEC malectin -2.77141
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) -2.75356
CCNB2 cyclin B2 -2.75109
HYOU1 hypoxia up-regulated 1 -2.69965
LDHD lactate dehydrogenase D -2.69001
TM9SF3 transmembrane 9 superfamily member 3 -2.66529
LBR lamin B receptor -2.64556
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.64467
MAPK13 mitogen-activated protein kinase 13 -2.64377
STMN1 stathmin 1 -2.64115
FEN1 flap structure-specific endonuclease 1 -2.63449
JMJD6 jumonji domain containing 6 -2.63204
CHMP4B charged multivesicular body protein 4B -2.59327
COG2 component of oligomeric golgi complex 2 -2.58228
MAT1A methionine adenosyltransferase I, alpha -2.57566
PRDX5 peroxiredoxin 5 -2.5586
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.52842
SAA4 serum amyloid A4, constitutive -2.51317
RFC3 replication factor C (activator 1) 3, 38kDa -2.49551
HMGA2 high mobility group AT-hook 2 -2.4951
HPD 4-hydroxyphenylpyruvate dioxygenase -2.46421
COL3A1 collagen, type III, alpha 1 -2.46285
DSCC1 DNA replication and sister chromatid cohesion 1 -2.44773
BIRC5 baculoviral IAP repeat containing 5 -2.42957
ORM2 orosomucoid 2 -2.41707
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.401
MCM10 minichromosome maintenance complex component 10 -2.39898
CDC6 cell division cycle 6 -2.38372
POMK protein-O-mannose kinase -2.37471
TRIP13 thyroid hormone receptor interactor 13 -2.37203
C8A complement component 8, alpha polypeptide -2.36963
ATAD2 ATPase family, AAA domain containing 2 -2.36629
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.33512
S100A8 S100 calcium binding protein A8 -2.31559
DSG2 desmoglein 2 -2.3118
PLG plasminogen -2.3059
MYH10 myosin, heavy chain 10, non-muscle -2.30287
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2 -2.29682
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -2.2906
TBC1D31 TBC1 domain family, member 31 -2.27913
HPX hemopexin -2.27307
BABAM1 BRISC and BRCA1 A complex member 1 -2.26839
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.26656
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.26329
RFC4 replication factor C (activator 1) 4, 37kDa -2.26316
CTNND1 catenin (cadherin-associated protein), delta 1 -2.25381
TTI1 TELO2 interacting protein 1 -2.24171
ACAA1 acetyl-CoA acyltransferase 1 -2.22657
KIF11 kinesin family member 11 -2.22507
HMG20B high mobility group 20B -2.22096
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 -2.21483
SPDL1 spindle apparatus coiled-coil protein 1 -2.20683
TIPIN TIMELESS interacting protein -2.20561
FGA fibrinogen alpha chain -2.2028
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) -2.19967
FANCG Fanconi anemia, complementation group G -2.19784
AMDHD2 amidohydrolase domain containing 2 -2.1954
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) -2.19228
C4BPA complement component 4 binding protein, alpha -2.18151
VDAC1 voltage-dependent anion channel 1 -2.17517
HEATR1 HEAT repeat containing 1 -2.16848
ARID3A AT rich interactive domain 3A (BRIGHT-like) -2.16774
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.16519
SLC35B1 solute carrier family 35, member B1 -2.16417
APOA1 apolipoprotein A-I -2.16114
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.16001
UXT ubiquitously-expressed, prefoldin-like chaperone -2.15321
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.14969
SMC4 structural maintenance of chromosomes 4 -2.13626
DNM1L dynamin 1-like -2.13448
TTC13 tetratricopeptide repeat domain 13 -2.1202
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.09866
SARS2 seryl-tRNA synthetase 2, mitochondrial -2.08195
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.0691
ASGR2 asialoglycoprotein receptor 2 -2.06786
WDR18 WD repeat domain 18 -2.06157
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) -2.06023
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.05552
COPS7A COP9 signalosome subunit 7A -2.04516
SPTBN2 spectrin, beta, non-erythrocytic 2 -2.04348
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 -2.04055
TMEM209 transmembrane protein 209 -2.03799
TLR4 toll-like receptor 4 -2.03042
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.02787
BLMH bleomycin hydrolase -2.02555
ZMIZ1 zinc finger, MIZ-type containing 1 -2.02187
NCAPH non-SMC condensin I complex, subunit H -2.0128
KHSRP KH-type splicing regulatory protein -2.01053
NCAPD2 non-SMC condensin I complex, subunit D2 -2.01024
PUM3 pumilio RNA binding family member 3 -2.00827
LAPTM4A lysosomal protein transmembrane 4 alpha -2.00793
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -2.00566