CRCGN014_HEPG2_24H:D10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description toluene diisocyanate 40.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN014_HEPG2_24H:D10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADRB2 adrenoceptor beta 2, surface 6.82735
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.72991
PPARG peroxisome proliferator-activated receptor gamma 5.95189
TIAM1 T-cell lymphoma invasion and metastasis 1 4.63055
RPP38 ribonuclease P/MRP 38kDa subunit 4.49452
SYNE2 spectrin repeat containing, nuclear envelope 2 3.75549
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.60117
CHMP6 charged multivesicular body protein 6 3.42963
MCOLN1 mucolipin 1 3.40378
SQOR sulfide quinone oxidoreductase 3.22881
MOK MOK protein kinase 3.20975
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.17189
CCNF cyclin F 3.03788
INTS3 integrator complex subunit 3 3.0014
CDPF1 cysteine-rich, DPF motif domain containing 1 2.92637
SOCS2 suppressor of cytokine signaling 2 2.48231
FZD7 frizzled class receptor 7 2.39791
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.25728
NOSIP nitric oxide synthase interacting protein 2.15063
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.12983
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.11702
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.06984
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.0035

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -6.07334
CHMP4B charged multivesicular body protein 4B -5.7358
PCNA proliferating cell nuclear antigen -4.73397
LDHD lactate dehydrogenase D -3.24589
TLR4 toll-like receptor 4 -3.23792
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.23235
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.14759
TM9SF2 transmembrane 9 superfamily member 2 -3.13733
TUBB6 tubulin, beta 6 class V -3.09566
KDM3A lysine (K)-specific demethylase 3A -3.00567
CDC20 cell division cycle 20 -3.00274
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.9743
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.97315
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.91641
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.83742
SCAND1 SCAN domain containing 1 -2.75583
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.67847
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.60545
ANO3 anoctamin 3 -2.59627
GSE1 Gse1 coiled-coil protein -2.49827
SNX11 sorting nexin 11 -2.47087
DGKB diacylglycerol kinase, beta 90kDa -2.4383
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.40488
CTNND1 catenin (cadherin-associated protein), delta 1 -2.3777
CLIP3 CAP-GLY domain containing linker protein 3 -2.16735
RGS9BP regulator of G protein signaling 9 binding protein -2.14238
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.10627
GPR6 G protein-coupled receptor 6 -2.10537
ARC activity-regulated cytoskeleton-associated protein -2.08798
PPP1R9A protein phosphatase 1, regulatory subunit 9A -2.08749
PECR peroxisomal trans-2-enoyl-CoA reductase -2.08465
ZNF345 zinc finger protein 345 -2.06053
ADORA2A adenosine A2a receptor -2.0517
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.03058
HMG20B high mobility group 20B -2.01965
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 -2.0157
FBXL7 F-box and leucine-rich repeat protein 7 -2.00469