CRCGN014_HEPG2_24H:D12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimethyl terephthalate 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

75 genes differentially expressed following the CRCGN014_HEPG2_24H:D12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 8.28101
MAP7 microtubule-associated protein 7 7.6047
TIAM1 T-cell lymphoma invasion and metastasis 1 7.1572
RPP38 ribonuclease P/MRP 38kDa subunit 6.63682
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.68319
SYNE2 spectrin repeat containing, nuclear envelope 2 4.4872
MINDY1 MINDY lysine 48 deubiquitinase 1 4.34456
DYNLT3 dynein, light chain, Tctex-type 3 4.24081
C2CD2 C2 calcium-dependent domain containing 2 3.92808
E2F2 E2F transcription factor 2 3.8402
CBR3 carbonyl reductase 3 3.10979
GPER1 G protein-coupled estrogen receptor 1 3.04971
DNM1 dynamin 1 3.00411
ATP11B ATPase, class VI, type 11B 2.85831
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.72328
STIMATE STIM activating enhancer 2.51207
ADRB2 adrenoceptor beta 2, surface 2.50836
RGS2 regulator of G-protein signaling 2 2.50634
CXCR4 chemokine (C-X-C motif) receptor 4 2.47406
SMIM40 small integral membrane protein 40 2.43657
NOSIP nitric oxide synthase interacting protein 2.39049
CARMIL1 capping protein regulator and myosin 1 linker 1 2.30995
PRR15L proline rich 15-like 2.30796
AMDHD2 amidohydrolase domain containing 2 2.29995
TSPAN6 tetraspanin 6 2.22081
SKIC8 SKI8 subunit of superkiller complex 2.1796
IGSF1 immunoglobulin superfamily, member 1 2.13069
RALGDS ral guanine nucleotide dissociation stimulator 2.10926
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.07732

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -8.21678
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.45134
PCNA proliferating cell nuclear antigen -5.1281
TM9SF3 transmembrane 9 superfamily member 3 -5.04144
DERA deoxyribose-phosphate aldolase (putative) -4.49799
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.62334
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.596
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.49579
TLR4 toll-like receptor 4 -3.23244
ZDHHC6 zinc finger, DHHC-type containing 6 -2.79127
TMC5 transmembrane channel-like 5 -2.72574
MRPS2 mitochondrial ribosomal protein S2 -2.49787
ACLY ATP citrate lyase -2.46923
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.45095
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.45047
DSG2 desmoglein 2 -2.4481
GNAS GNAS complex locus -2.40205
CCNB2 cyclin B2 -2.39125
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.36598
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 -2.36198
SNX11 sorting nexin 11 -2.35204
ATAD3A ATPase family, AAA domain containing 3A -2.33276
GFER growth factor, augmenter of liver regeneration -2.32935
EGF epidermal growth factor -2.26212
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.20804
MYL7 myosin, light chain 7, regulatory -2.18761
PSENEN presenilin enhancer gamma secretase subunit -2.17735
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) -2.17643
REEP5 receptor accessory protein 5 -2.15983
RIN1 Ras and Rab interactor 1 -2.15084
TMEM147 transmembrane protein 147 -2.14943
RNF167 ring finger protein 167 -2.14684
KDM3A lysine (K)-specific demethylase 3A -2.13324
TM9SF2 transmembrane 9 superfamily member 2 -2.12401
HDAC7 histone deacetylase 7 -2.11428
HAUS5 HAUS augmin-like complex, subunit 5 -2.11121
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.07972
PPOX protoporphyrinogen oxidase -2.07503
EGLN2 egl-9 family hypoxia-inducible factor 2 -2.05256
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 -2.0407
MYOG myogenin (myogenic factor 4) -2.03709
CPLX3 complexin 3 -2.02961
FXR2 fragile X mental retardation, autosomal homolog 2 -2.01767
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -2.01363
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.01157
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 -2.00776