CRCGN014_HEPG2_24H:D15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description g-butyrolactone 39.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN014_HEPG2_24H:D15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 4.76254
SQOR sulfide quinone oxidoreductase 4.62554
LCN2 lipocalin 2 4.35169
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.30853
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.89851
SMIM40 small integral membrane protein 40 3.84404
GSTZ1 glutathione S-transferase zeta 1 3.42491
PLSCR3 phospholipid scramblase 3 3.08891
CHN1 chimerin 1 3.01885
MSRA methionine sulfoxide reductase A 2.89224
HLA-DRA major histocompatibility complex, class II, DR alpha 2.79674
SATB1 SATB homeobox 1 2.67903
NMU neuromedin U 2.45208
CIAO3 cytosolic iron-sulfur assembly component 3 2.4329
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.33579
KIF20A kinesin family member 20A 2.30862
DIPK1A divergent protein kinase domain 1A 2.28011
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.20809
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.13576
SIRT3 sirtuin 3 2.06342

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -7.34826
VAT1 vesicle amine transport 1 -5.30469
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.20967
TLR4 toll-like receptor 4 -3.67777
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.15862
MAPK13 mitogen-activated protein kinase 13 -3.03701
STX4 syntaxin 4 -3.02509
FAIM Fas apoptotic inhibitory molecule -2.92394
LAP3 leucine aminopeptidase 3 -2.86358
ZNF586 zinc finger protein 586 -2.66914
NUP85 nucleoporin 85kDa -2.45059
CHMP4B charged multivesicular body protein 4B -2.05182