| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | (s)-cyano(3-phenoxyphenyl)methyl (1r,3r)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate 20.15 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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81 genes differentially expressed following the CRCGN014_HEPG2_24H:D17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 7.15741 |
| RXYLT1 | ribitol xylosyltransferase 1 | 4.25013 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 4.13772 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.11995 |
| SQOR | sulfide quinone oxidoreductase | 4.04703 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 3.98621 |
| ADRB2 | adrenoceptor beta 2, surface | 3.91061 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.90279 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.84376 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 3.8333 |
| PHKG2 | phosphorylase kinase, gamma 2 (testis) | 3.78307 |
| MYLK | myosin light chain kinase | 3.7147 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 3.63872 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.29274 |
| SATB1 | SATB homeobox 1 | 3.20493 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 3.16379 |
| ATP11B | ATPase, class VI, type 11B | 3.15071 |
| HDGFL3 | HDGF like 3 | 3.14904 |
| MAP7 | microtubule-associated protein 7 | 3.06115 |
| GATA3 | GATA binding protein 3 | 3.03915 |
| CCNF | cyclin F | 2.99291 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 2.8859 |
| EPN2 | epsin 2 | 2.83262 |
| CYCS | cytochrome c, somatic | 2.74216 |
| EPHB2 | EPH receptor B2 | 2.73872 |
| ICAM1 | intercellular adhesion molecule 1 | 2.69028 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.6764 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 2.63796 |
| KIF20A | kinesin family member 20A | 2.55193 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.50741 |
| CHAF1B | chromatin assembly factor 1, subunit B (p60) | 2.4866 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 2.44269 |
| CCL2 | chemokine (C-C motif) ligand 2 | 2.36979 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.36701 |
| CNTLN | centlein, centrosomal protein | 2.35151 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.34791 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 2.26113 |
| DHDDS | dehydrodolichyl diphosphate synthase | 2.20973 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 2.16414 |
| MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | 2.11767 |
| BAMBI | BMP and activin membrane-bound inhibitor | 2.10594 |
| CHEK2 | checkpoint kinase 2 | 2.09807 |
| RAPGEFL1 | Rap guanine nucleotide exchange factor (GEF)-like 1 | 2.06684 |
| BIRC2 | baculoviral IAP repeat containing 2 | 2.04653 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD320 | CD320 molecule | -6.07313 |
| CCDC86 | coiled-coil domain containing 86 | -4.28266 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -4.11392 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -4.10881 |
| KDM3A | lysine (K)-specific demethylase 3A | -4.09969 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -4.00921 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -3.93905 |
| DNM1L | dynamin 1-like | -3.93573 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -3.75259 |
| LDHD | lactate dehydrogenase D | -3.58175 |
| TUBB6 | tubulin, beta 6 class V | -3.51487 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -3.4952 |
| COG2 | component of oligomeric golgi complex 2 | -3.46218 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.45732 |
| TLCD3A | TLC domain containing 3A | -3.44154 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -3.43024 |
| CDC20 | cell division cycle 20 | -3.40506 |
| TRIB3 | tribbles pseudokinase 3 | -3.40227 |
| CDC25B | cell division cycle 25B | -3.21699 |
| PCNA | proliferating cell nuclear antigen | -3.17778 |
| VAT1 | vesicle amine transport 1 | -3.12062 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -3.10923 |
| TENT4A | terminal nucleotidyltransferase 4A | -2.91873 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.90942 |
| CHMP4B | charged multivesicular body protein 4B | -2.82885 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -2.53717 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.3718 |
| GNAS | GNAS complex locus | -2.36453 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -2.32517 |
| DPP8 | dipeptidyl-peptidase 8 | -2.32204 |
| HMG20B | high mobility group 20B | -2.3087 |
| GPHRA | golgi pH regulator A | -2.27535 |
| RNF167 | ring finger protein 167 | -2.23575 |
| CCNB1 | cyclin B1 | -2.22327 |
| FOXO4 | forkhead box O4 | -2.1149 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -2.11053 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.01841 |
