CRCGN014_HEPG2_24H:D19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description d-mannitol 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN014_HEPG2_24H:D19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 10.0
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
EVL Enah/Vasp-like 3.82575
MAMLD1 mastermind-like domain containing 1 3.3116
EPN2 epsin 2 3.27812
HLA-DRA major histocompatibility complex, class II, DR alpha 3.26945
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.02349
LOC122526780 uncharacterized LOC122526780 2.95543
SQOR sulfide quinone oxidoreductase 2.91789
RPP38 ribonuclease P/MRP 38kDa subunit 2.89477
FZD7 frizzled class receptor 7 2.85113
STK10 serine/threonine kinase 10 2.83592
HOXA10 homeobox A10 2.74504
MSRA methionine sulfoxide reductase A 2.71187
NOTCH1 notch 1 2.69038
HEBP1 heme binding protein 1 2.651
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.48705
E2F2 E2F transcription factor 2 2.46385
GARRE1 granule associated Rac and RHOG effector 1 2.4296
TRAM2 translocation associated membrane protein 2 2.37861
SLC66A2 solute carrier family 66 member 2 2.30903
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 2.30423
UIMC1 ubiquitin interaction motif containing 1 2.2654
MRNIP MRN complex interacting protein 2.26263
SIRT3 sirtuin 3 2.22813
GPR3 G protein-coupled receptor 3 2.18062
ENTREP2 endosomal transmembrane epsin interactor 2 2.17182
POU4F1 POU class 4 homeobox 1 2.17059
VGLL4 vestigial-like family member 4 2.14527
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.14116
MAP7 microtubule-associated protein 7 2.13411
SLC26A2 solute carrier family 26 (anion exchanger), member 2 2.11778
RXYLT1 ribitol xylosyltransferase 1 2.0972
ZSCAN32 zinc finger and SCAN domain containing 32 2.09585
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 2.0811
SPTBN5 spectrin, beta, non-erythrocytic 5 2.07307
ALOX12 arachidonate 12-lipoxygenase 2.03986
FAM234B family with sequence similarity 234 member B 2.0363
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 2.01653
TAGLN3 transgelin 3 2.00839
MXD3 MAX dimerization protein 3 2.00196

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -6.67016
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.05473
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.76434
RFC2 replication factor C (activator 1) 2, 40kDa -4.08953
PLK1 polo-like kinase 1 -3.71377
GDF15 growth differentiation factor 15 -3.67703
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.33174
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.32984
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.13707
CCNB1 cyclin B1 -3.10021
VDAC1 voltage-dependent anion channel 1 -2.86644
MRPS2 mitochondrial ribosomal protein S2 -2.80493
GOLT1B golgi transport 1B -2.80349
TUBB6 tubulin, beta 6 class V -2.59672
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.29791
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.24877
WDR46 WD repeat domain 46 -2.24255
ITM2A integral membrane protein 2A -2.20422
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.12894
GSTT1 glutathione S-transferase theta 1 -2.10818
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.0821