| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 9-ethyl-9h-carbazol-3-amine hydrochloride 20.26 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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120 genes differentially expressed following the CRCGN014_HEPG2_24H:D20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 9.96422 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 6.47833 |
| PPARG | peroxisome proliferator-activated receptor gamma | 6.34591 |
| STIMATE | STIM activating enhancer | 4.94517 |
| GATA3 | GATA binding protein 3 | 4.36344 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 4.24135 |
| NOSIP | nitric oxide synthase interacting protein | 4.13053 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.72026 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 3.71152 |
| CBR3 | carbonyl reductase 3 | 3.69889 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 3.69265 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 3.64534 |
| E2F2 | E2F transcription factor 2 | 3.50614 |
| CHN1 | chimerin 1 | 3.48282 |
| PLS1 | plastin 1 | 3.40602 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 3.28941 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.1997 |
| NOTCH1 | notch 1 | 3.14977 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 3.07437 |
| VGLL4 | vestigial-like family member 4 | 3.06625 |
| PLSCR1 | phospholipid scramblase 1 | 2.98302 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 2.94369 |
| TATDN2 | TatD DNase domain containing 2 | 2.87787 |
| ATG7 | autophagy related 7 | 2.84232 |
| PFKL | phosphofructokinase, liver | 2.79221 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | 2.79171 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.68713 |
| CCNF | cyclin F | 2.67866 |
| STXBP1 | syntaxin binding protein 1 | 2.59975 |
| MCM3 | minichromosome maintenance complex component 3 | 2.59273 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | 2.58497 |
| ABHD6 | abhydrolase domain containing 6 | 2.49296 |
| CYCS | cytochrome c, somatic | 2.44777 |
| ABHD4 | abhydrolase domain containing 4 | 2.40879 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 2.40448 |
| ACOX1 | acyl-CoA oxidase 1, palmitoyl | 2.37372 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 2.3352 |
| SLC30A10 | solute carrier family 30, member 10 | 2.30439 |
| MACROH2A2 | macroH2A.2 histone | 2.26743 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 2.25898 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.25026 |
| PLSCR3 | phospholipid scramblase 3 | 2.21231 |
| ACOT8 | acyl-CoA thioesterase 8 | 2.19494 |
| KDM5A | lysine (K)-specific demethylase 5A | 2.19249 |
| PIK3R2 | phosphoinositide-3-kinase, regulatory subunit 2 (beta) | 2.18414 |
| DNAL4 | dynein, axonemal, light chain 4 | 2.18065 |
| NAGA | N-acetylgalactosaminidase, alpha- | 2.1803 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 2.15668 |
| HSPA1A | heat shock 70kDa protein 1A | 2.15614 |
| GET3 | guided entry of tail-anchored proteins factor 3, ATPase | 2.13492 |
| THOC6 | THO complex 6 | 2.133 |
| TOR3A | torsin family 3, member A | 2.13235 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.13208 |
| SULT1E1 | sulfotransferase family 1E, estrogen-preferring, member 1 | 2.12888 |
| FZD7 | frizzled class receptor 7 | 2.08016 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 2.06897 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | 2.03145 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.02552 |
| TACO1 | translational activator of mitochondrially encoded cytochrome c oxidase I | 2.02388 |
| DCAF11 | DDB1 and CUL4 associated factor 11 | 2.02106 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 2.00025 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -9.664 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -8.86559 |
| PCNA | proliferating cell nuclear antigen | -8.18657 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -6.68923 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -6.59779 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -5.36827 |
| ADI1 | acireductone dioxygenase 1 | -5.3629 |
| KDM3A | lysine (K)-specific demethylase 3A | -4.40571 |
| DUSP6 | dual specificity phosphatase 6 | -4.17062 |
| DNM1L | dynamin 1-like | -4.08477 |
| TLCD3A | TLC domain containing 3A | -4.00237 |
| THAP11 | THAP domain containing 11 | -3.86959 |
| TUBB6 | tubulin, beta 6 class V | -3.82917 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -3.29473 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.21162 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -3.20829 |
| CD320 | CD320 molecule | -3.14059 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -3.06482 |
| TRIB3 | tribbles pseudokinase 3 | -3.03193 |
| ZNF586 | zinc finger protein 586 | -3.01052 |
| NGRN | neugrin, neurite outgrowth associated | -2.99308 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.91501 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.89809 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -2.89191 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -2.86424 |
| RBM34 | RNA binding motif protein 34 | -2.73555 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -2.72908 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -2.71145 |
| COPB1 | coatomer protein complex, subunit beta 1 | -2.68956 |
| LYPLA1 | lysophospholipase I | -2.6525 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.63629 |
| INSIG1 | insulin induced gene 1 | -2.54137 |
| HSPB1 | heat shock 27kDa protein 1 | -2.48942 |
| HEATR1 | HEAT repeat containing 1 | -2.47603 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.36625 |
| FHOD1 | formin homology 2 domain containing 1 | -2.35624 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -2.34066 |
| VAT1 | vesicle amine transport 1 | -2.32112 |
| SNRPE | small nuclear ribonucleoprotein polypeptide E | -2.22469 |
| LAMTOR5 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 | -2.21029 |
| ETFA | electron-transfer-flavoprotein, alpha polypeptide | -2.20893 |
| RPN1 | ribophorin I | -2.20859 |
| GOLGA8F | golgin A8 family, member F | -2.18073 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -2.17609 |
| MRGBP | MRG/MORF4L binding protein | -2.16088 |
| FAIM | Fas apoptotic inhibitory molecule | -2.14378 |
| ACTMAP | actin maturation protease | -2.12986 |
| PDCD5 | programmed cell death 5 | -2.10721 |
| NEK7 | NIMA-related kinase 7 | -2.10642 |
| EIF3M | eukaryotic translation initiation factor 3, subunit M | -2.09518 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.0841 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -2.08118 |
| PPM1A | protein phosphatase, Mg2+/Mn2+ dependent, 1A | -2.08101 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -2.0791 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -2.06829 |
| PAXIP1 | PAX interacting (with transcription-activation domain) protein 1 | -2.0549 |
| CHEK1 | checkpoint kinase 1 | -2.01847 |
| RAI1 | retinoic acid induced 1 | -2.00696 |
| RNF11 | ring finger protein 11 | -2.00535 |
