CRCGN014_HEPG2_24H:D21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description iq 21.02 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN014_HEPG2_24H:D21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.58839
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.26514
NMU neuromedin U 3.81198
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.48365
PPARG peroxisome proliferator-activated receptor gamma 3.4689
MSRA methionine sulfoxide reductase A 3.25956
PNKP polynucleotide kinase 3'-phosphatase 3.13277
CHN1 chimerin 1 2.79385
NOSIP nitric oxide synthase interacting protein 2.63556
TREM1 triggering receptor expressed on myeloid cells 1 2.47453
DIPK1A divergent protein kinase domain 1A 2.40595
SFTPB surfactant protein B 2.38993
CNPY3 canopy FGF signaling regulator 3 2.26561
GARRE1 granule associated Rac and RHOG effector 1 2.18514
NES nestin 2.07991
KDM5A lysine (K)-specific demethylase 5A 2.07659
SLC75A1 solute carrier family 75 member 1 2.02814

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.9779
PCCB propionyl CoA carboxylase, beta polypeptide -3.28081
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.23747
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.07784
PGAM4 phosphoglycerate mutase family member 4 -3.07732
PTPRK protein tyrosine phosphatase, receptor type, K -3.07029
FBXL12 F-box and leucine-rich repeat protein 12 -2.77986
CCP110 centriolar coiled coil protein 110kDa -2.5541
MAPK13 mitogen-activated protein kinase 13 -2.3569
INPP1 inositol polyphosphate-1-phosphatase -2.20228
C5 complement component 5 -2.12924
GADD45A growth arrest and DNA-damage-inducible, alpha -2.08299
FGFR4 fibroblast growth factor receptor 4 -2.04341
SOAT2 sterol O-acyltransferase 2 -2.02114