CRCGN014_HEPG2_24H:D22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description thioacetamide 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN014_HEPG2_24H:D22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 4.20314
RPP38 ribonuclease P/MRP 38kDa subunit 4.0531
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 3.77708
HOXA10 homeobox A10 3.73578
NOTCH1 notch 1 3.57821
CASP10 caspase 10, apoptosis-related cysteine peptidase 3.41899
CXCL2 chemokine (C-X-C motif) ligand 2 3.37366
GPER1 G protein-coupled estrogen receptor 1 3.00738
GSTZ1 glutathione S-transferase zeta 1 3.00452
MAP7 microtubule-associated protein 7 3.00071
KIF5C kinesin family member 5C 2.73143
SOCS2 suppressor of cytokine signaling 2 2.64994
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.48923
RBMX RNA binding motif protein, X-linked 2.37115
CD1D CD1d molecule 2.1563
CYCS cytochrome c, somatic 2.05541
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 2.02143

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -9.5697
COG2 component of oligomeric golgi complex 2 -5.72892
PCNA proliferating cell nuclear antigen -5.40617
CCNB2 cyclin B2 -4.71113
PEG10 paternally expressed 10 -4.42931
ACOT9 acyl-CoA thioesterase 9 -4.19231
LDHD lactate dehydrogenase D -3.6573
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.58802
TLCD3A TLC domain containing 3A -3.35179
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.85389
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.79306
MAPK13 mitogen-activated protein kinase 13 -2.77812
GNAS GNAS complex locus -2.5997
EGF epidermal growth factor -2.34867
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -2.24927
RBBP7 retinoblastoma binding protein 7 -2.03174