CRCGN014_HEPG2_24H:D24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description propyl gallate 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN014_HEPG2_24H:D24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 5.66829
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 4.655
TXNRD1 thioredoxin reductase 1 4.19223
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 4.18453
CDC45 cell division cycle 45 3.90491
DIPK1A divergent protein kinase domain 1A 3.70789
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.67862
ABHD4 abhydrolase domain containing 4 3.60867
CIAO3 cytosolic iron-sulfur assembly component 3 3.52474
NOTCH1 notch 1 3.46118
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.21755
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.17311
EVL Enah/Vasp-like 3.12892
HMOX1 heme oxygenase 1 3.11725
KEAP1 kelch-like ECH-associated protein 1 3.11166
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.09987
EPHB2 EPH receptor B2 3.0354
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.0105
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.96519
UGDH UDP-glucose 6-dehydrogenase 2.96373
CXCL2 chemokine (C-X-C motif) ligand 2 2.88944
SFTPB surfactant protein B 2.86667
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.75644
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.6794
DDIT4 DNA-damage-inducible transcript 4 2.57317
CHMP6 charged multivesicular body protein 6 2.55324
TENT4A terminal nucleotidyltransferase 4A 2.36749
ALAS1 5'-aminolevulinate synthase 1 2.33114
RPP38 ribonuclease P/MRP 38kDa subunit 2.29696
CCP110 centriolar coiled coil protein 110kDa 2.2
TBC1D31 TBC1 domain family, member 31 2.17953
ALDOC aldolase C, fructose-bisphosphate 2.11006
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.10616
KDM3A lysine (K)-specific demethylase 3A 2.08366

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.72586
CDC20 cell division cycle 20 -5.49841
SLC35F2 solute carrier family 35, member F2 -5.10312
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.99181
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.97383
ZDHHC6 zinc finger, DHHC-type containing 6 -3.78983
PLK1 polo-like kinase 1 -3.62487
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.61196
ARID5B AT rich interactive domain 5B (MRF1-like) -3.5459
UBE2C ubiquitin-conjugating enzyme E2C -3.05401
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.97553
TLR4 toll-like receptor 4 -2.96959
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.81329
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.66689
PSRC1 proline/serine-rich coiled-coil 1 -2.64463
ILK integrin-linked kinase -2.59017
FGFR4 fibroblast growth factor receptor 4 -2.51799
NUP62 nucleoporin 62kDa -2.47743
CD320 CD320 molecule -2.46747
FBXL12 F-box and leucine-rich repeat protein 12 -2.4168
MYL9 myosin, light chain 9, regulatory -2.37345
GNAS GNAS complex locus -2.31278
CDC25B cell division cycle 25B -2.30758
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.27601
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.12729
CCNB2 cyclin B2 -2.12282
ZNF862 zinc finger protein 862 -2.12218
PUF60 poly-U binding splicing factor 60KDa -2.0443
CYTL1 cytokine-like 1 -2.03901
HAT1 histone acetyltransferase 1 -2.01544