CRCGN014_HEPG2_24H:E01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description [(phosphonomethyl)amino]acetic acid compound with 2-propanamine (1:1) 20.45 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

353 genes differentially expressed following the CRCGN014_HEPG2_24H:E01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 6.86795
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.81388
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.70464
RPL39L ribosomal protein L39-like 6.46223
ADRB2 adrenoceptor beta 2, surface 6.39897
CXCL2 chemokine (C-X-C motif) ligand 2 5.56418
CCNF cyclin F 4.59878
MAP7 microtubule-associated protein 7 4.54484
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 4.23909
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.22376
GPATCH8 G patch domain containing 8 3.94982
PRKCH protein kinase C, eta 3.9344
TBXA2R thromboxane A2 receptor 3.90458
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.80766
STAP2 signal transducing adaptor family member 2 3.71203
INTS3 integrator complex subunit 3 3.64864
MAST2 microtubule associated serine/threonine kinase 2 3.62954
AMDHD2 amidohydrolase domain containing 2 3.59591
GSTZ1 glutathione S-transferase zeta 1 3.57555
EGF epidermal growth factor 3.56262
CCDC92 coiled-coil domain containing 92 3.53795
PNKP polynucleotide kinase 3'-phosphatase 3.52625
SYNE2 spectrin repeat containing, nuclear envelope 2 3.494
KLHL21 kelch-like family member 21 3.41023
EVL Enah/Vasp-like 3.31594
HDGFL3 HDGF like 3 3.23794
NNT nicotinamide nucleotide transhydrogenase 3.23149
UBQLN2 ubiquilin 2 3.22545
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.21731
BACE2 beta-site APP-cleaving enzyme 2 3.20978
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 3.20948
SFTPB surfactant protein B 3.19754
LAGE3 L antigen family, member 3 3.19196
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.17097
CHMP6 charged multivesicular body protein 6 3.15026
RPP38 ribonuclease P/MRP 38kDa subunit 3.05968
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.00803
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.97601
CHN1 chimerin 1 2.9545
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.94983
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.86857
MRLN myoregulin 2.86379
VAV3 vav 3 guanine nucleotide exchange factor 2.8635
TMEM223 transmembrane protein 223 2.85443
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.85301
PAX7 paired box 7 2.84917
INSRR insulin receptor-related receptor 2.84774
MOK MOK protein kinase 2.8467
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.82771
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.82677
NPY4R2 neuropeptide Y receptor Y4-2 2.82129
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 2.81868
PLA2G2E phospholipase A2, group IIE 2.77525
ADGRE5 adhesion G protein-coupled receptor E5 2.76588
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.76363
FSCN2 fascin actin-bundling protein 2, retinal 2.75822
SQOR sulfide quinone oxidoreductase 2.7579
DGKQ diacylglycerol kinase, theta 110kDa 2.75395
TSPO2 translocator protein 2 2.72332
FOXB1 forkhead box B1 2.72123
PDZD7 PDZ domain containing 7 2.69782
KIF17 kinesin family member 17 2.69672
PLS1 plastin 1 2.69631
OR3A3 olfactory receptor, family 3, subfamily A, member 3 2.69464
SNAP25 synaptosomal-associated protein, 25kDa 2.6909
CAPN11 calpain 11 2.67143
STK10 serine/threonine kinase 10 2.66952
OR1E2 olfactory receptor, family 1, subfamily E, member 2 2.66771
PYGM phosphorylase, glycogen, muscle 2.6653
RIOX1 ribosomal oxygenase 1 2.65942
S1PR5 sphingosine-1-phosphate receptor 5 2.6529
LAG3 lymphocyte-activation gene 3 2.64761
MICALL1 MICAL-like 1 2.64581
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.64374
NOTCH1 notch 1 2.64244
HOPX HOP homeobox 2.63576
PARP11 poly (ADP-ribose) polymerase family, member 11 2.61637
CBR3 carbonyl reductase 3 2.61075
PAX1 paired box 1 2.5952
TMEM40 transmembrane protein 40 2.57459
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.56261
CENPC centromere protein C 2.55339
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 2.54195
SHH sonic hedgehog 2.53976
GATA3 GATA binding protein 3 2.53941
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.53446
CCDC70 coiled-coil domain containing 70 2.5283
BICRA BRD4 interacting chromatin remodeling complex associated protein 2.52617
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 2.51431
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4 2.51156
IL22 interleukin 22 2.49773
PRLH prolactin releasing hormone 2.48265
MTNR1B melatonin receptor 1B 2.48182
PRSS50 protease, serine, 50 2.47591
GPR27 G protein-coupled receptor 27 2.47222
SHBG sex hormone-binding globulin 2.47082
ZBTB7B zinc finger and BTB domain containing 7B 2.45568
CSN1S1 casein alpha s1 2.44396
CAV3 caveolin 3 2.43632
OVOL3 ovo-like zinc finger 3 2.43269
ADGRG1 adhesion G protein-coupled receptor G1 2.43213
MYO19 myosin XIX 2.42944
POU3F3 POU class 3 homeobox 3 2.42284
SMG6 SMG6 nonsense mediated mRNA decay factor 2.42136
EPHB2 EPH receptor B2 2.42019
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 2.41453
ZSCAN2 zinc finger and SCAN domain containing 2 2.41059
SCN10A sodium channel, voltage gated, type X alpha subunit 2.40684
FN3K fructosamine 3 kinase 2.40086
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 2.39847
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.39537
CDX4 caudal type homeobox 4 2.38975
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.38727
KIFC3 kinesin family member C3 2.38409
AANAT aralkylamine N-acetyltransferase 2.37961
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 2.37835
EVX1 even-skipped homeobox 1 2.37738
NEUROG3 neurogenin 3 2.37489
ADM2 adrenomedullin 2 2.3697
NRDE2 NRDE-2, necessary for RNA interference, domain containing 2.36894
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.36677
MLYCD malonyl-CoA decarboxylase 2.36094
MAPK4 mitogen-activated protein kinase 4 2.34895
EMC10 ER membrane protein complex subunit 10 2.34692
SYNPO2L synaptopodin 2-like 2.34116
CSDC2 cold shock domain containing C2, RNA binding 2.34014
ACBD4 acyl-CoA binding domain containing 4 2.33852
IRGC immunity-related GTPase family, cinema 2.33814
CARD14 caspase recruitment domain family, member 14 2.33583
FBXW10B F-box and WD repeat domain containing 10B 2.33485
GALR2 galanin receptor 2 2.32661
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.32252
GUCY2F guanylate cyclase 2F, retinal 2.32167
PLSCR3 phospholipid scramblase 3 2.32041
CEND1 cell cycle exit and neuronal differentiation 1 2.31866
ZNF750 zinc finger protein 750 2.3115
NECTIN1 nectin cell adhesion molecule 1 2.31122
GPR173 G protein-coupled receptor 173 2.30957
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.307
TNNT3 troponin T type 3 (skeletal, fast) 2.30693
GJA5 gap junction protein, alpha 5, 40kDa 2.30688
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) 2.30522
MFSD6 major facilitator superfamily domain containing 6 2.30332
EPHA3 EPH receptor A3 2.29782
PITPNM3 PITPNM family member 3 2.28819
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.28161
EVC Ellis van Creveld protein 2.27933
ANGPT4 angiopoietin 4 2.27893
BICDL1 BICD family like cargo adaptor 1 2.27836
NKX2-8 NK2 homeobox 8 2.27693
PRDM8 PR domain containing 8 2.27453
PPARG peroxisome proliferator-activated receptor gamma 2.27382
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.27323
BRDT bromodomain, testis-specific 2.26732
JADE2 jade family PHD finger 2 2.26595
GALR3 galanin receptor 3 2.26241
S100A5 S100 calcium binding protein A5 2.25546
GRTP1 growth hormone regulated TBC protein 1 2.255
FNDC8 fibronectin type III domain containing 8 2.2529
PKP1 plakophilin 1 2.25103
GRIA4 glutamate receptor, ionotropic, AMPA 4 2.25055
OXT oxytocin/neurophysin I prepropeptide 2.24519
SPATA31A3 SPATA31 subfamily A, member 3 2.23854
CXCR3 chemokine (C-X-C motif) receptor 3 2.23708
HSFX2 heat shock transcription factor family, X linked 2 2.23574
LIM2 lens intrinsic membrane protein 2, 19kDa 2.23358
S1PR2 sphingosine-1-phosphate receptor 2 2.22943
TSSK2 testis-specific serine kinase 2 2.226
OR1D4 olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene) 2.22134
CRHR2 corticotropin releasing hormone receptor 2 2.21337
SH2D3C SH2 domain containing 3C 2.19916
RAX retina and anterior neural fold homeobox 2.19873
LMO1 LIM domain only 1 (rhombotin 1) 2.19521
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 2.19475
PSPN persephin 2.19456
SOX21 SRY (sex determining region Y)-box 21 2.19358
FAT2 FAT atypical cadherin 2 2.18943
GFI1B growth factor independent 1B transcription repressor 2.18719
ALOX12 arachidonate 12-lipoxygenase 2.18587
OMP olfactory marker protein 2.18422
TEX28 testis expressed 28 2.18407
CT55 cancer/testis antigen 55 2.18092
OVOL1 ovo-like zinc finger 1 2.17802
TSSK1B testis-specific serine kinase 1B 2.1743
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 2.16815
TESK1 testis-specific kinase 1 2.1677
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 2.16572
GPR68 G protein-coupled receptor 68 2.16472
EPHX3 epoxide hydrolase 3 2.16462
CRYBG2 crystallin beta-gamma domain containing 2 2.16305
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.16287
FSTL4 follistatin-like 4 2.1596
LOC124900193 uncharacterized LOC124900193 2.1576
TUBA8 tubulin, alpha 8 2.15665
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta 2.15519
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.15507
TRAT1 T cell receptor associated transmembrane adaptor 1 2.1527
TPSD1 tryptase delta 1 2.15042
ABHD6 abhydrolase domain containing 6 2.15004
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.14958
TREH trehalase (brush-border membrane glycoprotein) 2.14818
CHRD chordin 2.14697
SLC22A14 solute carrier family 22, member 14 2.1459
SEC31B SEC31 homolog B (S. cerevisiae) 2.14571
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.1455
PRDM12 PR domain containing 12 2.14405
PDCD1 programmed cell death 1 2.14204
LYZL6 lysozyme-like 6 2.13293
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.13207
DOC2B double C2-like domains, beta 2.12666
GJA3 gap junction protein, alpha 3, 46kDa 2.12643
TLE6 transducin-like enhancer of split 6 2.12539
SRPK3 SRSF protein kinase 3 2.12494
AVPR1B arginine vasopressin receptor 1B 2.12199
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 2.12066
DLK2 delta-like 2 homolog (Drosophila) 2.12031
IL21 interleukin 21 2.11832
DCAF1 DDB1 and CUL4 associated factor 1 2.11773
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.11569
GJC2 gap junction protein, gamma 2, 47kDa 2.1156
RBMS3 RNA binding motif, single stranded interacting protein 3 2.11461
SBSPON somatomedin B and thrombospondin, type 1 domain containing 2.11355
NEU3 sialidase 3 (membrane sialidase) 2.11304
TEC tec protein tyrosine kinase 2.11294
RAB40A RAB40A, member RAS oncogene family 2.10603
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.10493
IRX5 iroquois homeobox 5 2.10485
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 2.10345
XCR1 chemokine (C motif) receptor 1 2.10318
HSPB3 heat shock 27kDa protein 3 2.10159
IKZF4 IKAROS family zinc finger 4 (Eos) 2.09879
POMC proopiomelanocortin 2.09816
KRT36 keratin 36, type I 2.09629
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.0932
HEYL hes-related family bHLH transcription factor with YRPW motif-like 2.09248
PVRIG poliovirus receptor related immunoglobulin domain containing 2.09203
PHEX phosphate regulating endopeptidase homolog, X-linked 2.09106
LALBA lactalbumin, alpha- 2.08619
ACTN3 actinin, alpha 3 (gene/pseudogene) 2.08471
NCOR2 nuclear receptor corepressor 2 2.08433
JMJD7 jumonji domain containing 7 2.08248
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.08154
POM121 POM121 transmembrane nucleoporin 2.07468
VWA7 von Willebrand factor A domain containing 7 2.07448
KIAA1614 KIAA1614 2.07402
VCX3A variable charge, X-linked 3A 2.07258
MYOD1 myogenic differentiation 1 2.07254
LOC122526780 uncharacterized LOC122526780 2.07162
GPX5 glutathione peroxidase 5 2.07087
RCVRN recoverin 2.06993
TNN tenascin N 2.06689
KLF15 Kruppel-like factor 15 2.0662
TMPRSS11E transmembrane protease, serine 11E 2.06592
FER fer (fps/fes related) tyrosine kinase 2.06585
CATSPERG catsper channel auxiliary subunit gamma 2.0655
JPH2 junctophilin 2 2.0619
DGKG diacylglycerol kinase, gamma 90kDa 2.06176
PCDHA2 protocadherin alpha 2 2.06124
ECEL1 endothelin converting enzyme-like 1 2.06083
SCT secretin 2.06005
SIGLEC8 sialic acid binding Ig-like lectin 8 2.05852
PAX3 paired box 3 2.05471
DOT1L DOT1-like histone H3K79 methyltransferase 2.05426
DNAAF8 dynein axonemal assembly factor 8 2.05194
MIMS2 mitochondrial inner membrane scaffold 2 2.05047
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 2.04915
LCN2 lipocalin 2 2.04332
NCR1 natural cytotoxicity triggering receptor 1 2.04257
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 2.04216
H1-1 H1.1 linker histone, cluster member 2.0417
GUCA1B guanylate cyclase activator 1B (retina) 2.04089
OR10H2 olfactory receptor, family 10, subfamily H, member 2 2.03361
CER1 cerberus 1, DAN family BMP antagonist 2.03281
CLCN2 chloride channel, voltage-sensitive 2 2.03253
EDNRA endothelin receptor type A 2.0297
NTN3 netrin 3 2.02885
CCKAR cholecystokinin A receptor 2.02828
HRH2 histamine receptor H2 2.02801
ARR3 arrestin 3, retinal (X-arrestin) 2.02608
TMED1 transmembrane emp24 protein transport domain containing 1 2.02186
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 2.01843
LRRC14 leucine rich repeat containing 14 2.01626
TLX2 T-cell leukemia homeobox 2 2.01116
PI15 peptidase inhibitor 15 2.01074
LYPLA2 lysophospholipase II 2.0097
DSG3 desmoglein 3 2.00866
HTN3 histatin 3 2.00632
TULP1 tubby like protein 1 2.00616
PTH1R parathyroid hormone 1 receptor 2.00372
TMEM143 transmembrane protein 143 2.00121
ANK1 ankyrin 1, erythrocytic 2.00109

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -7.03428
DNM1L dynamin 1-like -6.79245
CCDC86 coiled-coil domain containing 86 -6.23304
DUSP6 dual specificity phosphatase 6 -4.58868
COG7 component of oligomeric golgi complex 7 -4.4962
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.31914
C2CD5 C2 calcium-dependent domain containing 5 -4.21456
DSG2 desmoglein 2 -4.18033
KDM3A lysine (K)-specific demethylase 3A -4.06854
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.05669
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.02071
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.91864
GOLT1B golgi transport 1B -3.84454
MRPS16 mitochondrial ribosomal protein S16 -3.7768
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.77221
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.65597
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.63767
PEG10 paternally expressed 10 -3.57148
LDHD lactate dehydrogenase D -3.48926
MRPS2 mitochondrial ribosomal protein S2 -3.43177
TUBB6 tubulin, beta 6 class V -3.40711
NGRN neugrin, neurite outgrowth associated -3.28311
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.15053
THAP11 THAP domain containing 11 -3.14655
FAIM Fas apoptotic inhibitory molecule -3.12905
CHMP4B charged multivesicular body protein 4B -3.11151
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.10292
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.08138
HMG20B high mobility group 20B -3.04652
TLR4 toll-like receptor 4 -2.94115
ITGB1BP1 integrin beta 1 binding protein 1 -2.88857
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.87622
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.83093
ANKRD10 ankyrin repeat domain 10 -2.8005
SCAND1 SCAN domain containing 1 -2.78505
TRIB3 tribbles pseudokinase 3 -2.73269
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.6371
CTNND1 catenin (cadherin-associated protein), delta 1 -2.60736
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -2.55937
LYPLA1 lysophospholipase I -2.46159
CCDC6 coiled-coil domain containing 6 -2.44033
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.4034
HEATR1 HEAT repeat containing 1 -2.35649
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.34856
CCNB1 cyclin B1 -2.32964
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.3227
RUVBL1 RuvB-like AAA ATPase 1 -2.28735
PAK1IP1 PAK1 interacting protein 1 -2.20182
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.18374
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.14719
TOR1A torsin family 1, member A (torsin A) -2.14674
MACF1 microtubule-actin crosslinking factor 1 -2.1122
DCTPP1 dCTP pyrophosphatase 1 -2.10308
RAD51AP1 RAD51 associated protein 1 -2.06819
FOS FBJ murine osteosarcoma viral oncogene homolog -2.06462
DERA deoxyribose-phosphate aldolase (putative) -2.06305
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -2.04728
SLC12A8 solute carrier family 12, member 8 -2.04652
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -2.03213
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -2.02256
YME1L1 YME1-like 1 ATPase -2.00363
MNT MAX network transcriptional repressor -2.00227