CRCGN014_HEPG2_24H:E05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tin (ii) chloride 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN014_HEPG2_24H:E05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 7.34151
SQOR sulfide quinone oxidoreductase 6.33552
CXCL2 chemokine (C-X-C motif) ligand 2 4.95301
CNPY3 canopy FGF signaling regulator 3 4.56012
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.68456
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.46558
C2CD2 C2 calcium-dependent domain containing 2 3.45134
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.37818
RPL39L ribosomal protein L39-like 3.24043
STK10 serine/threonine kinase 10 3.1758
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.11586
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.00147
AMDHD2 amidohydrolase domain containing 2 2.98795
MAMLD1 mastermind-like domain containing 1 2.98674
INTS3 integrator complex subunit 3 2.90402
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.89355
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.89216
SFTPB surfactant protein B 2.75527
TIAM1 T-cell lymphoma invasion and metastasis 1 2.75387
HLA-DMA major histocompatibility complex, class II, DM alpha 2.66208
MYLK myosin light chain kinase 2.61953
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.47119
STIMATE STIM activating enhancer 2.24204
GATA3 GATA binding protein 3 2.15039
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.10262
KDM5A lysine (K)-specific demethylase 5A 2.0587
CDPF1 cysteine-rich, DPF motif domain containing 1 2.02992

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -5.27704
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.97756
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.75324
TLR4 toll-like receptor 4 -3.75316
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.61884
ADI1 acireductone dioxygenase 1 -3.61828
TP53BP2 tumor protein p53 binding protein 2 -3.4669
MRPS2 mitochondrial ribosomal protein S2 -3.44629
LAP3 leucine aminopeptidase 3 -3.32543
CAB39 calcium binding protein 39 -3.31183
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.30152
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.269
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.97997
DERA deoxyribose-phosphate aldolase (putative) -2.93608
CD320 CD320 molecule -2.87042
FHL2 four and a half LIM domains 2 -2.77134
GTPBP8 GTP-binding protein 8 (putative) -2.68916
MRPS16 mitochondrial ribosomal protein S16 -2.68004
PUF60 poly-U binding splicing factor 60KDa -2.64316
CDC20 cell division cycle 20 -2.58659
CDC25B cell division cycle 25B -2.43838
ZDHHC6 zinc finger, DHHC-type containing 6 -2.40211
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.38409
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.21148
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.04342