CRCGN014_HEPG2_24H:E07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

122 genes differentially expressed following the CRCGN014_HEPG2_24H:E07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 7.52467
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 7.35451
ADRB2 adrenoceptor beta 2, surface 7.30503
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 6.17268
AMDHD2 amidohydrolase domain containing 2 5.57372
GSTZ1 glutathione S-transferase zeta 1 5.21966
TIAM1 T-cell lymphoma invasion and metastasis 1 5.14441
MAP7 microtubule-associated protein 7 4.94995
ATP11B ATPase, class VI, type 11B 4.86372
SATB1 SATB homeobox 1 4.82642
MICALL1 MICAL-like 1 4.69608
UBQLN2 ubiquilin 2 4.66398
DYNLT3 dynein, light chain, Tctex-type 3 4.62599
KLHL21 kelch-like family member 21 4.62012
CARMIL1 capping protein regulator and myosin 1 linker 1 4.54321
HDGFL3 HDGF like 3 3.91666
CHN1 chimerin 1 3.90838
ZNF589 zinc finger protein 589 3.90533
VGLL4 vestigial-like family member 4 3.77391
VAV3 vav 3 guanine nucleotide exchange factor 3.7498
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.68642
PMM2 phosphomannomutase 2 3.42984
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.37192
LOC122526780 uncharacterized LOC122526780 3.29707
ARL4C ADP-ribosylation factor-like 4C 3.22209
GAA glucosidase, alpha; acid 3.18067
CCNF cyclin F 3.1333
PRR15L proline rich 15-like 3.1199
RPP38 ribonuclease P/MRP 38kDa subunit 2.94218
TBP TATA box binding protein 2.9242
ABHD6 abhydrolase domain containing 6 2.8852
CCDC85B coiled-coil domain containing 85B 2.86879
MAST2 microtubule associated serine/threonine kinase 2 2.79434
MAPK6 mitogen-activated protein kinase 6 2.77947
CCL2 chemokine (C-C motif) ligand 2 2.66922
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.6189
FZD7 frizzled class receptor 7 2.61428
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.50355
DSG3 desmoglein 3 2.40159
COL9A1 collagen, type IX, alpha 1 2.37035
GARRE1 granule associated Rac and RHOG effector 1 2.36214
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.35414
EVL Enah/Vasp-like 2.32928
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2.29831
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.27381
TENM3 teneurin transmembrane protein 3 2.26968
CHAF1B chromatin assembly factor 1, subunit B (p60) 2.2685
PITPNB phosphatidylinositol transfer protein, beta 2.2684
RNF208 ring finger protein 208 2.26771
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 2.20497
OXCT1 3-oxoacid CoA transferase 1 2.19438
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 2.188
NUTF2 nuclear transport factor 2 2.1845
TOM1L2 target of myb1-like 2 (chicken) 2.17918
CD40LG CD40 ligand 2.16306
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.16024
CHEK2 checkpoint kinase 2 2.14385
COL4A5 collagen, type IV, alpha 5 2.12217
LY86 lymphocyte antigen 86 2.09123
CASQ2 calsequestrin 2 (cardiac muscle) 2.08248
PES1 pescadillo ribosomal biogenesis factor 1 2.06236
CRELD1 cysteine-rich with EGF-like domains 1 2.05191
VTA1 vesicle (multivesicular body) trafficking 1 2.04931
CD48 CD48 molecule 2.0461
COL10A1 collagen, type X, alpha 1 2.03961
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 2.03505
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 2.03418
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 2.03322
CFAP298 cilia and flagella associated protein 298 2.0274
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.01434
TATDN2 TatD DNase domain containing 2 2.01156
SH3GL3 SH3-domain GRB2-like 3 2.01088
ZNF26 zinc finger protein 26 2.0104

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -10.0
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.76167
ZDHHC6 zinc finger, DHHC-type containing 6 -5.51572
VAT1 vesicle amine transport 1 -5.49756
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.9708
KDM3A lysine (K)-specific demethylase 3A -4.73025
TRIB3 tribbles pseudokinase 3 -4.69281
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -4.68246
LDHD lactate dehydrogenase D -4.5459
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.47523
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.36113
GDF15 growth differentiation factor 15 -4.31356
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.2917
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.19558
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.13012
COG2 component of oligomeric golgi complex 2 -4.08518
JMJD6 jumonji domain containing 6 -3.81234
TM9SF3 transmembrane 9 superfamily member 3 -3.72952
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.29432
UBE3C ubiquitin protein ligase E3C -3.17847
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.17559
TOMM34 translocase of outer mitochondrial membrane 34 -2.99679
ITGB1BP1 integrin beta 1 binding protein 1 -2.937
MRPS2 mitochondrial ribosomal protein S2 -2.86556
TENT4A terminal nucleotidyltransferase 4A -2.79238
SCCPDH saccharopine dehydrogenase (putative) -2.74309
RNF167 ring finger protein 167 -2.71158
ZMIZ1 zinc finger, MIZ-type containing 1 -2.67965
LAP3 leucine aminopeptidase 3 -2.6082
NRIP1 nuclear receptor interacting protein 1 -2.57737
MAPK13 mitogen-activated protein kinase 13 -2.55305
CDC20 cell division cycle 20 -2.48412
TRIM8 tripartite motif containing 8 -2.46949
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.45613
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.42424
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.4239
DNM1L dynamin 1-like -2.36322
SLC35F2 solute carrier family 35, member F2 -2.32717
ZW10 zw10 kinetochore protein -2.27275
ADI1 acireductone dioxygenase 1 -2.24126
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.19218
PCNA proliferating cell nuclear antigen -2.18499
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.14846
YME1L1 YME1-like 1 ATPase -2.13167
HPCAL1 hippocalcin-like 1 -2.12252
CAPN1 calpain 1, (mu/I) large subunit -2.0951
RBM39 RNA binding motif protein 39 -2.08346
CDHR1 cadherin-related family member 1 -2.02449
DUSP14 dual specificity phosphatase 14 -2.01686