CRCGN014_HEPG2_24H:E08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN014_HEPG2_24H:E08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 7.0165
CHMP6 charged multivesicular body protein 6 5.88495
UBQLN2 ubiquilin 2 5.3155
NOTCH1 notch 1 5.3151
CYCS cytochrome c, somatic 4.89565
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.84025
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.73815
GATA3 GATA binding protein 3 3.4765
ATP11B ATPase, class VI, type 11B 3.36505
ZNF589 zinc finger protein 589 3.35418
PRR15L proline rich 15-like 3.08315
CHN1 chimerin 1 3.0725
PMM2 phosphomannomutase 2 3.03
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.828
SNX7 sorting nexin 7 2.60515
KIF20A kinesin family member 20A 2.3759
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.3405
MTX2 metaxin 2 2.16145
RFTN1 raftlin, lipid raft linker 1 2.1605
COQ9 coenzyme Q9 2.1019

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -5.1988
ZNF586 zinc finger protein 586 -5.1215
CD320 CD320 molecule -5.0468
FABP5 fatty acid binding protein 5 (psoriasis-associated) -5.0
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.9356
CDC20 cell division cycle 20 -4.8605
LDHD lactate dehydrogenase D -4.7944
ZW10 zw10 kinetochore protein -3.5392
CCNB2 cyclin B2 -3.03285
EGF epidermal growth factor -2.64605
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.57792
TBP TATA box binding protein -2.57315
ITGB1BP1 integrin beta 1 binding protein 1 -2.45703
FBXL12 F-box and leucine-rich repeat protein 12 -2.457
SLC35F2 solute carrier family 35, member F2 -2.42495
TRAPPC6A trafficking protein particle complex 6A -2.41275
ARID4A AT rich interactive domain 4A (RBP1-like) -2.2255
UBAP1 ubiquitin associated protein 1 -2.16563
PCBP4 poly(rC) binding protein 4 -2.0757
HYOU1 hypoxia up-regulated 1 -2.0683
MXRA8 matrix-remodelling associated 8 -2.0139
EPCAM epithelial cell adhesion molecule -2.0127
CD4 CD4 molecule -2.01095
PXDNL peroxidasin-like -2.00975
STXBP1 syntaxin binding protein 1 -2.00755