CRCGN014_HEPG2_24H:E10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hydrazine sulfate 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN014_HEPG2_24H:E10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 9.02745
CBR3 carbonyl reductase 3 6.14694
LCN2 lipocalin 2 5.46237
MAP7 microtubule-associated protein 7 4.43581
CHN1 chimerin 1 3.72574
CXCR4 chemokine (C-X-C motif) receptor 4 3.51587
AMDHD2 amidohydrolase domain containing 2 3.3915
MYLK myosin light chain kinase 3.35833
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.28927
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.18004
STK10 serine/threonine kinase 10 3.16676
RPL39L ribosomal protein L39-like 3.15545
NOTCH1 notch 1 3.0732
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.03044
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.80745
MMP1 matrix metallopeptidase 1 2.77704
KDM5A lysine (K)-specific demethylase 5A 2.65191
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.64969
SKIC8 SKI8 subunit of superkiller complex 2.59694
GPER1 G protein-coupled estrogen receptor 1 2.44906
VGLL4 vestigial-like family member 4 2.43628
CD40 CD40 molecule, TNF receptor superfamily member 5 2.34548
HDGFL3 HDGF like 3 2.29204
PEX11A peroxisomal biogenesis factor 11 alpha 2.27294
HLA-DRA major histocompatibility complex, class II, DR alpha 2.24714
EPHB2 EPH receptor B2 2.14762
CYB561 cytochrome b561 2.08996
SATB1 SATB homeobox 1 2.04356
RXYLT1 ribitol xylosyltransferase 1 2.02838
CCNF cyclin F 2.00759

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -9.1552
CD320 CD320 molecule -8.06505
TLCD3A TLC domain containing 3A -4.94655
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.02174
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.8777
GADD45A growth arrest and DNA-damage-inducible, alpha -3.69185
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -3.57555
CDC20 cell division cycle 20 -3.54164
TRIB3 tribbles pseudokinase 3 -3.53697
OXA1L oxidase (cytochrome c) assembly 1-like -3.29305
THAP11 THAP domain containing 11 -3.25991
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.25511
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.99624
ARID5B AT rich interactive domain 5B (MRF1-like) -2.937
RAI14 retinoic acid induced 14 -2.89014
DSG2 desmoglein 2 -2.8417
TSPAN4 tetraspanin 4 -2.73643
ZMIZ1 zinc finger, MIZ-type containing 1 -2.70639
ITGB1BP1 integrin beta 1 binding protein 1 -2.67434
FAIM Fas apoptotic inhibitory molecule -2.39972
EIF5 eukaryotic translation initiation factor 5 -2.39265
ACAA1 acetyl-CoA acyltransferase 1 -2.33178
CHMP4B charged multivesicular body protein 4B -2.32675
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -2.25085
PUS3 pseudouridylate synthase 3 -2.24535
HSPA1L heat shock 70kDa protein 1-like -2.2123
PLA1A phospholipase A1 member A -2.16554
AMIGO2 adhesion molecule with Ig-like domain 2 -2.15315
PRPF4 pre-mRNA processing factor 4 -2.1369
ZNF280A zinc finger protein 280A -2.10538
FGFR4 fibroblast growth factor receptor 4 -2.07396
ADIPOR1 adiponectin receptor 1 -2.04084
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.02536
MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough -2.02335