CRCGN014_HEPG2_24H:E16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description prednisolone 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

52 genes differentially expressed following the CRCGN014_HEPG2_24H:E16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 8.56287
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.83759
CHMP6 charged multivesicular body protein 6 4.09428
TIAM1 T-cell lymphoma invasion and metastasis 1 4.05732
STK10 serine/threonine kinase 10 3.83536
ANO1 anoctamin 1, calcium activated chloride channel 3.70977
EAPP E2F-associated phosphoprotein 3.69778
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.65786
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.65398
BACE2 beta-site APP-cleaving enzyme 2 3.45649
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.45032
PPARG peroxisome proliferator-activated receptor gamma 3.38324
RPP38 ribonuclease P/MRP 38kDa subunit 3.21879
ZFP36 ZFP36 ring finger protein 3.1997
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.09146
KIFBP kinesin family binding protein 2.96397
HOXA10 homeobox A10 2.94682
BLMH bleomycin hydrolase 2.91475
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.76845
MAMLD1 mastermind-like domain containing 1 2.71101
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.64169
SMIM40 small integral membrane protein 40 2.52387
LCN2 lipocalin 2 2.36442
GTPBP8 GTP-binding protein 8 (putative) 2.28778
CA14 carbonic anhydrase XIV 2.13627
CBR3 carbonyl reductase 3 2.11944
DDIT4 DNA-damage-inducible transcript 4 2.08661
GRB10 growth factor receptor-bound protein 10 2.06723
ROPN1B rhophilin associated tail protein 1B 2.04973
E2F2 E2F transcription factor 2 2.00405

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.4246
TLR4 toll-like receptor 4 -5.36149
ADI1 acireductone dioxygenase 1 -4.91265
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.3295
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.90909
VAT1 vesicle amine transport 1 -3.79828
HMG20B high mobility group 20B -3.70741
FASTKD5 FAST kinase domains 5 -3.67888
UGDH UDP-glucose 6-dehydrogenase -3.67539
DNM1L dynamin 1-like -3.51298
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.48075
CHMP4B charged multivesicular body protein 4B -3.07088
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.02491
DSG2 desmoglein 2 -2.89449
MRPS2 mitochondrial ribosomal protein S2 -2.82037
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.69728
COG2 component of oligomeric golgi complex 2 -2.62729
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A -2.42473
RNF167 ring finger protein 167 -2.40781
TRIB3 tribbles pseudokinase 3 -2.1353
CCNB1 cyclin B1 -2.13408
VDAC1 voltage-dependent anion channel 1 -2.10399