CRCGN014_HEPG2_24H:E19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hexylresorcinol 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

295 genes differentially expressed following the CRCGN014_HEPG2_24H:E19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SHB Src homology 2 domain containing adaptor protein B 6.86937
UBE2L6 ubiquitin-conjugating enzyme E2L 6 5.99323
BPHL biphenyl hydrolase-like (serine hydrolase) 5.87507
EDN1 endothelin 1 5.60924
GFOD1 glucose-fructose oxidoreductase domain containing 1 5.25888
CIAO3 cytosolic iron-sulfur assembly component 3 5.08373
PMM2 phosphomannomutase 2 4.96347
SMIM40 small integral membrane protein 40 4.72481
CCNA1 cyclin A1 4.41107
TESK1 testis-specific kinase 1 4.29679
E2F2 E2F transcription factor 2 4.20498
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 4.075
PTPRK protein tyrosine phosphatase, receptor type, K 4.06401
IFNAR1 interferon (alpha, beta and omega) receptor 1 4.0603
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.04332
BIRC2 baculoviral IAP repeat containing 2 4.03853
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.98249
HEBP1 heme binding protein 1 3.97406
CYCS cytochrome c, somatic 3.96466
STK10 serine/threonine kinase 10 3.95959
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 3.85955
CBR3 carbonyl reductase 3 3.82928
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.66033
CXCL2 chemokine (C-X-C motif) ligand 2 3.64493
NPDC1 neural proliferation, differentiation and control, 1 3.64088
IL1B interleukin 1, beta 3.62902
TRIM13 tripartite motif containing 13 3.53757
RAB21 RAB21, member RAS oncogene family 3.50374
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 3.4214
NOTCH1 notch 1 3.36733
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.33395
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 3.31623
LCN2 lipocalin 2 3.28943
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.18009
ATP11B ATPase, class VI, type 11B 3.11851
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.09048
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.08095
BAMBI BMP and activin membrane-bound inhibitor 3.03968
NVL nuclear VCP-like 3.02174
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 3.02122
ZFP36 ZFP36 ring finger protein 3.01427
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 3.00894
FAIM Fas apoptotic inhibitory molecule 2.96257
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.95846
CTSD cathepsin D 2.95446
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.94595
SFTPB surfactant protein B 2.93662
PRKX protein kinase, X-linked 2.92432
GADD45A growth arrest and DNA-damage-inducible, alpha 2.89333
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.86918
GRB7 growth factor receptor-bound protein 7 2.84482
UBQLN2 ubiquilin 2 2.80075
NGRN neugrin, neurite outgrowth associated 2.79287
SOX2 SRY (sex determining region Y)-box 2 2.78853
ALAS1 5'-aminolevulinate synthase 1 2.76829
KIFBP kinesin family binding protein 2.71897
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.7068
FKBP4 FK506 binding protein 4, 59kDa 2.68159
TNF tumor necrosis factor 2.66262
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.65791
TREM1 triggering receptor expressed on myeloid cells 1 2.64296
EXO5 exonuclease 5 2.61595
RAI14 retinoic acid induced 14 2.60161
MMP2 matrix metallopeptidase 2 2.59916
FGFR2 fibroblast growth factor receptor 2 2.59678
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.58831
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.58321
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.58232
ANXA1 annexin A1 2.58047
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.55543
MOB3B MOB kinase activator 3B 2.53968
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.52612
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.52083
SNX7 sorting nexin 7 2.50251
PTPN14 protein tyrosine phosphatase, non-receptor type 14 2.47869
SOCS2 suppressor of cytokine signaling 2 2.47843
GHR growth hormone receptor 2.46964
FANCE Fanconi anemia, complementation group E 2.45154
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 2.43472
H2BC12 H2B clustered histone 12 2.42144
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 2.41684
ZFP69B ZFP69 zinc finger protein B 2.40516
IL37 interleukin 37 2.4009
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 2.39958
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.39532
CERK ceramide kinase 2.38665
ARL4C ADP-ribosylation factor-like 4C 2.38082
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.37419
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.37278
HABP2 hyaluronan binding protein 2 2.3719
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 2.3517
MSRA methionine sulfoxide reductase A 2.34735
RGCC regulator of cell cycle 2.3454
ACVRL1 activin A receptor type II-like 1 2.3422
CYSLTR1 cysteinyl leukotriene receptor 1 2.34173
PRR15L proline rich 15-like 2.33628
CCL2 chemokine (C-C motif) ligand 2 2.32905
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 2.32605
TES testin LIM domain protein 2.31344
SCGB1D2 secretoglobin, family 1D, member 2 2.30982
LYN LYN proto-oncogene, Src family tyrosine kinase 2.30852
MTNR1A melatonin receptor 1A 2.28994
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 2.28423
SUSD4 sushi domain containing 4 2.28034
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.2789
RTN2 reticulon 2 2.27563
CAPN1 calpain 1, (mu/I) large subunit 2.27171
ZNF34 zinc finger protein 34 2.27094
PRAMEF10 PRAME family member 10 2.26954
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 2.26876
PACC1 proton activated chloride channel 1 2.26801
SIX3 SIX homeobox 3 2.25629
HTRA1 HtrA serine peptidase 1 2.25543
RRH retinal pigment epithelium-derived rhodopsin homolog 2.2551
NUCB2 nucleobindin 2 2.24924
BGN biglycan 2.2465
TBC1D31 TBC1 domain family, member 31 2.23943
MAGIX MAGI family member, X-linked 2.23589
PCDHA9 protocadherin alpha 9 2.2333
JAG2 jagged 2 2.23191
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 2.23112
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 2.2285
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 2.22546
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 2.2253
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.2247
CTNND1 catenin (cadherin-associated protein), delta 1 2.22122
NRG1 neuregulin 1 2.2208
TRIB3 tribbles pseudokinase 3 2.21913
ESM1 endothelial cell-specific molecule 1 2.2188
KIF26B kinesin family member 26B 2.21721
ZNF362 zinc finger protein 362 2.21483
RFTN1 raftlin, lipid raft linker 1 2.20988
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 2.20933
TENT4A terminal nucleotidyltransferase 4A 2.19288
ZNF250 zinc finger protein 250 2.18806
SHBG sex hormone-binding globulin 2.18704
NNAT neuronatin 2.186
ADAM9 ADAM metallopeptidase domain 9 2.18529
RUSC2 RUN and SH3 domain containing 2 2.18521
SIRPA signal-regulatory protein alpha 2.18286
CNTNAP3B contactin associated protein-like 3B 2.17572
NME6 NME/NM23 nucleoside diphosphate kinase 6 2.17104
DYSF dysferlin 2.16784
PDYN prodynorphin 2.16627
PELI1 pellino E3 ubiquitin protein ligase 1 2.15519
FAM234B family with sequence similarity 234 member B 2.1533
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.14232
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.14188
APOBR apolipoprotein B receptor 2.1391
AFAP1 actin filament associated protein 1 2.13729
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 2.12822
GPR3 G protein-coupled receptor 3 2.12327
CHN1 chimerin 1 2.1213
PGRMC2 progesterone receptor membrane component 2 2.11957
CD200R1 CD200 receptor 1 2.1179
NECAP1 NECAP endocytosis associated 1 2.11362
CEP41 centrosomal protein 41kDa 2.09961
TRIM8 tripartite motif containing 8 2.09876
TAS2R3 taste receptor, type 2, member 3 2.08705
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.08676
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.08164
TXNRD1 thioredoxin reductase 1 2.07935
TFDP3 transcription factor Dp family, member 3 2.07887
CEP15 centrosomal protein 15 2.07339
MMRN2 multimerin 2 2.07087
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 2.07073
CRYGA crystallin, gamma A 2.06982
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 2.06812
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 2.06701
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa 2.06356
OPN1SW opsin 1 (cone pigments), short-wave-sensitive 2.05938
EXT1 exostosin glycosyltransferase 1 2.05816
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2.05484
PKP2 plakophilin 2 2.05263
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2.04923
FZD1 frizzled class receptor 1 2.04402
ADAM21 ADAM metallopeptidase domain 21 2.03907
KLF11 Kruppel-like factor 11 2.03639
CRIP2 cysteine-rich protein 2 2.03068
ATG10 autophagy related 10 2.03038
OSGIN2 oxidative stress induced growth inhibitor family member 2 2.03032
PTPRT protein tyrosine phosphatase, receptor type, T 2.02998
OR3A1 olfactory receptor, family 3, subfamily A, member 1 2.0235
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 2.02225
EFHD1 EF-hand domain family, member D1 2.01831
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.01711
CORO2A coronin, actin binding protein, 2A 2.01707
SLC17A4 solute carrier family 17, member 4 2.01381
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.01167
SSTR4 somatostatin receptor 4 2.01094
OR10H3 olfactory receptor, family 10, subfamily H, member 3 2.01045
BHMT betaine--homocysteine S-methyltransferase 2.01006
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 2.00896
NXF3 nuclear RNA export factor 3 2.00509
PRDM14 PR domain containing 14 2.00247
CCDC30 coiled-coil domain containing 30 2.00234

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.97862
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -5.6771
CDC25B cell division cycle 25B -5.41178
TCTN1 tectonic family member 1 -5.28275
INTS3 integrator complex subunit 3 -4.92929
ZNF586 zinc finger protein 586 -4.58429
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.43569
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -4.28185
ANKRD10 ankyrin repeat domain 10 -4.24326
B4GAT1 beta-1,4-glucuronyltransferase 1 -4.12864
ETFB electron-transfer-flavoprotein, beta polypeptide -4.03974
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.97058
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.90619
CCDC86 coiled-coil domain containing 86 -3.81627
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.75221
CCNB1 cyclin B1 -3.64582
CCNB2 cyclin B2 -3.53687
SCCPDH saccharopine dehydrogenase (putative) -3.50384
TCERG1 transcription elongation regulator 1 -3.48822
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.43639
LBR lamin B receptor -3.32838
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -3.22193
HYOU1 hypoxia up-regulated 1 -3.21347
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -3.18499
SKIC2 SKI2 subunit of superkiller complex -3.15637
PSRC1 proline/serine-rich coiled-coil 1 -3.12556
GALE UDP-galactose-4-epimerase -3.11326
AMDHD2 amidohydrolase domain containing 2 -3.06439
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.05898
ALDOC aldolase C, fructose-bisphosphate -3.04311
ICAM3 intercellular adhesion molecule 3 -2.97215
C2CD5 C2 calcium-dependent domain containing 5 -2.94459
EED embryonic ectoderm development -2.94287
NNT nicotinamide nucleotide transhydrogenase -2.92825
GAA glucosidase, alpha; acid -2.92711
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.90832
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.86968
PCCB propionyl CoA carboxylase, beta polypeptide -2.84878
CDC20 cell division cycle 20 -2.8206
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.79973
HAT1 histone acetyltransferase 1 -2.79675
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.79228
RNF167 ring finger protein 167 -2.7546
BLMH bleomycin hydrolase -2.64038
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -2.62803
ARF5 ADP-ribosylation factor 5 -2.61248
TOP2A topoisomerase (DNA) II alpha 170kDa -2.60797
TWF2 twinfilin actin binding protein 2 -2.57949
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.54208
NISCH nischarin -2.51635
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.51536
ACAA1 acetyl-CoA acyltransferase 1 -2.50298
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.40906
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.40776
CDK1 cyclin-dependent kinase 1 -2.39543
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.39482
RSU1 Ras suppressor protein 1 -2.39027
MYLK myosin light chain kinase -2.37588
COG4 component of oligomeric golgi complex 4 -2.32267
ODF2 outer dense fiber of sperm tails 2 -2.31863
ANKRD17 ankyrin repeat domain 17 -2.31757
PTER phosphotriesterase related -2.31657
FOXO4 forkhead box O4 -2.31548
CDKN3 cyclin-dependent kinase inhibitor 3 -2.30546
MELK maternal embryonic leucine zipper kinase -2.30279
RHEB Ras homolog enriched in brain -2.29646
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.29359
DES desmin -2.29188
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.26273
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.25789
AFG3L2 AFG3-like AAA ATPase 2 -2.25049
STK25 serine/threonine kinase 25 -2.23812
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.21611
ZDHHC6 zinc finger, DHHC-type containing 6 -2.20813
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.20542
TM9SF3 transmembrane 9 superfamily member 3 -2.19937
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.1968
ENDOG endonuclease G -2.18646
PEBP1 phosphatidylethanolamine binding protein 1 -2.16665
GPD1L glycerol-3-phosphate dehydrogenase 1-like -2.15568
CASC3 cancer susceptibility candidate 3 -2.12157
USP6NL USP6 N-terminal like -2.12101
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) -2.11876
TBC1D10C TBC1 domain family, member 10C -2.09675
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 -2.09647
CST3 cystatin C -2.09078
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.09028
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.07992
PGM1 phosphoglucomutase 1 -2.07858
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.077
NCK1 NCK adaptor protein 1 -2.06949
YME1L1 YME1-like 1 ATPase -2.05883
CCNA2 cyclin A2 -2.0585
DDB2 damage-specific DNA binding protein 2, 48kDa -2.05707
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -2.04686
WTAP Wilms tumor 1 associated protein -2.03871
PIH1D1 PIH1 domain containing 1 -2.03451
CRTAP cartilage associated protein -2.02471
PLP1 proteolipid protein 1 -2.0129