CRCGN014_HEPG2_24H:E20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p,p'-dichlorodiphenyl sulfone 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN014_HEPG2_24H:E20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPP38 ribonuclease P/MRP 38kDa subunit 4.75483
UBQLN2 ubiquilin 2 4.6851
ADGRE5 adhesion G protein-coupled receptor E5 4.62566
TBC1D10C TBC1 domain family, member 10C 4.59479
MAP7 microtubule-associated protein 7 4.54069
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.52226
GPATCH8 G patch domain containing 8 4.22791
CARMIL1 capping protein regulator and myosin 1 linker 1 3.9487
GATA3 GATA binding protein 3 3.73035
PIH1D1 PIH1 domain containing 1 3.58045
PEX11A peroxisomal biogenesis factor 11 alpha 3.57115
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.49154
STK10 serine/threonine kinase 10 3.11617
CIAO3 cytosolic iron-sulfur assembly component 3 3.02995
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.80046
CCDC92 coiled-coil domain containing 92 2.79012
BPHL biphenyl hydrolase-like (serine hydrolase) 2.70126
ANO1 anoctamin 1, calcium activated chloride channel 2.68904
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.41243
PRR15L proline rich 15-like 2.13651
ICAM1 intercellular adhesion molecule 1 2.05496
ZNF589 zinc finger protein 589 2.02427

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -7.29999
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -7.12665
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -5.2033
PLK1 polo-like kinase 1 -5.11937
TLR4 toll-like receptor 4 -4.9768
MRPS16 mitochondrial ribosomal protein S16 -4.26865
CHMP4B charged multivesicular body protein 4B -4.26125
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.13251
TM9SF3 transmembrane 9 superfamily member 3 -3.87542
TBCB tubulin folding cofactor B -3.41119
FBXL12 F-box and leucine-rich repeat protein 12 -3.37363
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.32463
CAPNS1 calpain, small subunit 1 -3.13517
HMG20B high mobility group 20B -2.95984
CDC20 cell division cycle 20 -2.8642
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.84655
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.76752
GDF15 growth differentiation factor 15 -2.68904
CD320 CD320 molecule -2.59486
ADI1 acireductone dioxygenase 1 -2.47681
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.43572
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.30849
SPRR1B small proline-rich protein 1B -2.14752
MAPK13 mitogen-activated protein kinase 13 -2.14149
TMEM147 transmembrane protein 147 -2.08478
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.04453