CRCGN014_HEPG2_24H:E21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-phenyl-2-thiourea 40.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

35 genes differentially expressed following the CRCGN014_HEPG2_24H:E21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.77191
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.63654
JADE2 jade family PHD finger 2 4.8839
MAMLD1 mastermind-like domain containing 1 4.23528
E2F2 E2F transcription factor 2 4.16511
STAP2 signal transducing adaptor family member 2 3.86034
NOSIP nitric oxide synthase interacting protein 3.22319
BPHL biphenyl hydrolase-like (serine hydrolase) 3.18872
PEX11A peroxisomal biogenesis factor 11 alpha 3.16651
TIAM1 T-cell lymphoma invasion and metastasis 1 2.76223
SMIM40 small integral membrane protein 40 2.72771
TREM1 triggering receptor expressed on myeloid cells 1 2.53093
EVL Enah/Vasp-like 2.48095
CHN1 chimerin 1 2.39582
MAP7 microtubule-associated protein 7 2.34003
RXYLT1 ribitol xylosyltransferase 1 2.28962
LPAR2 lysophosphatidic acid receptor 2 2.17172
MCM3 minichromosome maintenance complex component 3 2.10642
SOCS2 suppressor of cytokine signaling 2 2.07617

decreased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 -8.5506
LDHD lactate dehydrogenase D -5.24597
TM9SF3 transmembrane 9 superfamily member 3 -4.97085
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.41038
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.25038
TOR1A torsin family 1, member A (torsin A) -4.11524
KDM3A lysine (K)-specific demethylase 3A -3.91635
RHEB Ras homolog enriched in brain -3.81117
DNM1L dynamin 1-like -3.78664
CDC20 cell division cycle 20 -3.62336
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.22897
HYOU1 hypoxia up-regulated 1 -2.91351
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.42706
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.22052
ICAM3 intercellular adhesion molecule 3 -2.21485
ADI1 acireductone dioxygenase 1 -2.19073