| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | di(2-ethylhexyl)phthalate 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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156 genes differentially expressed following the CRCGN014_HEPG2_24H:F01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PNKP | polynucleotide kinase 3'-phosphatase | 6.74003 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 6.4205 |
| MOK | MOK protein kinase | 6.3346 |
| E2F2 | E2F transcription factor 2 | 6.10867 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 6.00778 |
| PPARG | peroxisome proliferator-activated receptor gamma | 5.86658 |
| CHN1 | chimerin 1 | 5.60811 |
| ADRB2 | adrenoceptor beta 2, surface | 5.4398 |
| LCN2 | lipocalin 2 | 5.31325 |
| MAP7 | microtubule-associated protein 7 | 4.73778 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 4.70861 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 4.43214 |
| EGF | epidermal growth factor | 4.31256 |
| CBR3 | carbonyl reductase 3 | 3.99324 |
| SQOR | sulfide quinone oxidoreductase | 3.78538 |
| CCL2 | chemokine (C-C motif) ligand 2 | 3.72051 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 3.62505 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.50068 |
| RPL39L | ribosomal protein L39-like | 3.41388 |
| SATB1 | SATB homeobox 1 | 3.34899 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.3473 |
| PKN1 | protein kinase N1 | 3.32919 |
| NNT | nicotinamide nucleotide transhydrogenase | 3.22349 |
| GPATCH8 | G patch domain containing 8 | 3.21028 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.17206 |
| PLOD3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 3.14654 |
| NOTCH1 | notch 1 | 2.98131 |
| LOC122526780 | uncharacterized LOC122526780 | 2.95899 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 2.88828 |
| JADE2 | jade family PHD finger 2 | 2.86802 |
| DOCK2 | dedicator of cytokinesis 2 | 2.70786 |
| PLSCR1 | phospholipid scramblase 1 | 2.63473 |
| PIH1D1 | PIH1 domain containing 1 | 2.63206 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.60996 |
| LAGE3 | L antigen family, member 3 | 2.56941 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 2.56373 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.53235 |
| EPHA3 | EPH receptor A3 | 2.47259 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 2.45183 |
| WLS | wntless Wnt ligand secretion mediator | 2.42044 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 2.41851 |
| BCL7B | B-cell CLL/lymphoma 7B | 2.4147 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.40373 |
| CHMP6 | charged multivesicular body protein 6 | 2.39084 |
| IRS1 | insulin receptor substrate 1 | 2.36679 |
| TPD52L1 | tumor protein D52-like 1 | 2.34545 |
| OGFRL1 | opioid growth factor receptor-like 1 | 2.33189 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2.32735 |
| RSF1 | remodeling and spacing factor 1 | 2.32008 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.27289 |
| MYLK | myosin light chain kinase | 2.27087 |
| INTS3 | integrator complex subunit 3 | 2.25194 |
| TBX3 | T-box 3 | 2.24408 |
| HOXB9 | homeobox B9 | 2.24266 |
| GEMIN7 | gem (nuclear organelle) associated protein 7 | 2.23186 |
| PAGE4 | P antigen family, member 4 (prostate associated) | 2.22188 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 2.21673 |
| PXDC1 | PX domain containing 1 | 2.18513 |
| ASB13 | ankyrin repeat and SOCS box containing 13 | 2.18346 |
| MELK | maternal embryonic leucine zipper kinase | 2.16288 |
| TOPORS | topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase | 2.16033 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 2.16025 |
| KLHL36 | kelch-like family member 36 | 2.11412 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 2.11208 |
| SLC22A3 | solute carrier family 22 (organic cation transporter), member 3 | 2.09281 |
| PTOV1 | prostate tumor overexpressed 1 | 2.08653 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | 2.07902 |
| DOK1 | docking protein 1, 62kDa (downstream of tyrosine kinase 1) | 2.07775 |
| DNMBP | dynamin binding protein | 2.05894 |
| WASF2 | WAS protein family, member 2 | 2.04224 |
| SMR3B | submaxillary gland androgen regulated protein 3B | 2.04056 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 2.03496 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 2.03027 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 2.0302 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 2.02611 |
| PALS1 | protein associated with LIN7 1, MAGUK p55 family member | 2.0245 |
| STAT5A | signal transducer and activator of transcription 5A | 2.01647 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 2.0151 |
| DDX52 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 | 2.01203 |
| Symbol | Name | Standardized Value |
|---|---|---|
| C2CD5 | C2 calcium-dependent domain containing 5 | -6.21222 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -6.19455 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -6.15746 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -6.06778 |
| LDHD | lactate dehydrogenase D | -6.01333 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -5.65395 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -5.65078 |
| CCNB1 | cyclin B1 | -4.34974 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -4.24826 |
| PEG10 | paternally expressed 10 | -3.9257 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -3.81791 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -3.55224 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.465 |
| TLCD3A | TLC domain containing 3A | -3.46192 |
| ZNF146 | zinc finger protein 146 | -3.42 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.38114 |
| NVL | nuclear VCP-like | -3.34686 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.34492 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -3.30957 |
| TBCB | tubulin folding cofactor B | -2.99993 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.98171 |
| COG7 | component of oligomeric golgi complex 7 | -2.75285 |
| RGS2 | regulator of G-protein signaling 2 | -2.72858 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.63554 |
| RBM34 | RNA binding motif protein 34 | -2.57838 |
| TEX10 | testis expressed 10 | -2.51509 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -2.46489 |
| RNF187 | ring finger protein 187 | -2.43939 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -2.43894 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -2.37048 |
| PRUNE2 | prune homolog 2 (Drosophila) | -2.32622 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -2.29652 |
| TRIB3 | tribbles pseudokinase 3 | -2.27868 |
| TRIM37 | tripartite motif containing 37 | -2.27049 |
| COX6B1 | cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) | -2.26458 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.2638 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -2.262 |
| KCTD15 | potassium channel tetramerization domain containing 15 | -2.25738 |
| NUP85 | nucleoporin 85kDa | -2.25325 |
| PPOX | protoporphyrinogen oxidase | -2.24154 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -2.24112 |
| TP53BP2 | tumor protein p53 binding protein 2 | -2.22739 |
| ISG20L2 | interferon stimulated exonuclease gene 20kDa-like 2 | -2.21313 |
| AMZ2 | archaelysin family metallopeptidase 2 | -2.18282 |
| ZNF529 | zinc finger protein 529 | -2.17906 |
| THAP11 | THAP domain containing 11 | -2.17303 |
| POGLUT2 | protein O-glucosyltransferase 2 | -2.17153 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | -2.16844 |
| NARS1 | asparaginyl-tRNA synthetase 1 | -2.163 |
| BFAR | bifunctional apoptosis regulator | -2.14405 |
| VPS4B | vacuolar protein sorting 4 homolog B (S. cerevisiae) | -2.14042 |
| ABHD17A | abhydrolase domain containing 17A | -2.13546 |
| KDM3A | lysine (K)-specific demethylase 3A | -2.13502 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -2.13067 |
| PSMD8 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | -2.11334 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | -2.11287 |
| SAP30BP | SAP30 binding protein | -2.11233 |
| LAD1 | ladinin 1 | -2.11084 |
| RABEPK | Rab9 effector protein with kelch motifs | -2.1091 |
| TRIM39-RPP21 | TRIM39-RPP21 readthrough | -2.10283 |
| COX6C | cytochrome c oxidase subunit VIc | -2.09902 |
| TES | testin LIM domain protein | -2.08729 |
| NIT1 | nitrilase 1 | -2.07633 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -2.0725 |
| TMEM147 | transmembrane protein 147 | -2.07 |
| ATP6V0C | ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c | -2.05815 |
| NGRN | neugrin, neurite outgrowth associated | -2.05703 |
| ATP5PD | ATP synthase peripheral stalk subunit d | -2.04476 |
| PFDN2 | prefoldin subunit 2 | -2.03937 |
| NDUFS2 | NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) | -2.0258 |
| UQCRC2 | ubiquinol-cytochrome c reductase core protein II | -2.02491 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -2.02424 |
| ZNF74 | zinc finger protein 74 | -2.02321 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -2.0221 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | -2.01823 |
| PGAM4 | phosphoglycerate mutase family member 4 | -2.01314 |
| SNRPC | small nuclear ribonucleoprotein polypeptide C | -2.0122 |
