CRCGN014_HEPG2_24H:F02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methyl parathion 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

111 genes differentially expressed following the CRCGN014_HEPG2_24H:F02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCL2 chemokine (C-C motif) ligand 2 8.61415
DYNLT3 dynein, light chain, Tctex-type 3 4.7624
TIAM1 T-cell lymphoma invasion and metastasis 1 4.53369
CGRRF1 cell growth regulator with ring finger domain 1 4.14445
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.13753
AMDHD2 amidohydrolase domain containing 2 4.00447
C2CD2 C2 calcium-dependent domain containing 2 3.91236
CARMIL1 capping protein regulator and myosin 1 linker 1 3.55041
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.51491
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.42277
CHMP6 charged multivesicular body protein 6 3.40508
SYNE2 spectrin repeat containing, nuclear envelope 2 3.38181
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.26358
MINDY1 MINDY lysine 48 deubiquitinase 1 3.25673
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.18371
UBQLN2 ubiquilin 2 3.17
GPER1 G protein-coupled estrogen receptor 1 3.15905
CBR3 carbonyl reductase 3 3.11773
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.05334
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.99894
SQOR sulfide quinone oxidoreductase 2.95883
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.88769
ADRB2 adrenoceptor beta 2, surface 2.84076
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.80986
HDGFL3 HDGF like 3 2.8005
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.7901
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.77213
GATA3 GATA binding protein 3 2.76814
PNKP polynucleotide kinase 3'-phosphatase 2.59318
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.51927
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.49109
TREM1 triggering receptor expressed on myeloid cells 1 2.48206
TAC4 tachykinin 4 (hemokinin) 2.48157
NUP133 nucleoporin 133kDa 2.47119
HOXA10 homeobox A10 2.46108
PMM2 phosphomannomutase 2 2.43097
DMXL1 Dmx-like 1 2.40002
GPATCH8 G patch domain containing 8 2.38281
CYCS cytochrome c, somatic 2.37177
GDF2 growth differentiation factor 2 2.36109
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.35389
PCDHB1 protocadherin beta 1 2.32458
KLHL12 kelch-like family member 12 2.30419
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.28939
NEK11 NIMA-related kinase 11 2.26903
PPP4R3B protein phosphatase 4 regulatory subunit 3B 2.26788
HROB homologous recombination factor with OB-fold 2.19404
TLE6 transducin-like enhancer of split 6 2.16695
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.12729
CFAP44 cilia and flagella associated protein 44 2.10708
HAS2 hyaluronan synthase 2 2.10676
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.09944
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.09117
PRB4 proline-rich protein BstNI subfamily 4 2.08773
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 2.08478
ALX1 ALX homeobox 1 2.08314
SLC75A1 solute carrier family 75 member 1 2.08095
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 2.06344
IFNA13 interferon, alpha 13 2.05496
ZBTB7B zinc finger and BTB domain containing 7B 2.03443
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 2.02711
TTBK2 tau tubulin kinase 2 2.02704

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -7.55764
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.75078
GDF15 growth differentiation factor 15 -6.63017
LDHD lactate dehydrogenase D -6.52705
DSG2 desmoglein 2 -6.33973
TLCD3A TLC domain containing 3A -5.67978
PCNA proliferating cell nuclear antigen -5.0557
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -4.87124
TM9SF3 transmembrane 9 superfamily member 3 -4.74651
ADI1 acireductone dioxygenase 1 -4.66334
HMG20B high mobility group 20B -4.26795
MAPK13 mitogen-activated protein kinase 13 -4.0797
TRAP1 TNF receptor-associated protein 1 -3.84912
TRIB3 tribbles pseudokinase 3 -3.68077
MRPS2 mitochondrial ribosomal protein S2 -3.64827
HSPB1 heat shock 27kDa protein 1 -3.5403
RPIA ribose 5-phosphate isomerase A -3.31161
PECR peroxisomal trans-2-enoyl-CoA reductase -3.09171
LAP3 leucine aminopeptidase 3 -3.08715
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.01116
C2CD5 C2 calcium-dependent domain containing 5 -3.00522
KDM3A lysine (K)-specific demethylase 3A -2.95132
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.93624
SCAND1 SCAN domain containing 1 -2.9176
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.91463
ZDHHC6 zinc finger, DHHC-type containing 6 -2.87773
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.86427
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.83589
TSPAN4 tetraspanin 4 -2.83464
CCNB2 cyclin B2 -2.73631
LYPLA1 lysophospholipase I -2.67556
NCK1 NCK adaptor protein 1 -2.66656
CDC20 cell division cycle 20 -2.65451
RGS2 regulator of G-protein signaling 2 -2.63254
THAP11 THAP domain containing 11 -2.61164
CCNB1 cyclin B1 -2.59305
CHMP4B charged multivesicular body protein 4B -2.54182
CCDC86 coiled-coil domain containing 86 -2.47152
RBM34 RNA binding motif protein 34 -2.44926
NGRN neugrin, neurite outgrowth associated -2.39149
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.33596
TLR4 toll-like receptor 4 -2.27466
SNRPF small nuclear ribonucleoprotein polypeptide F -2.15962
ISCU iron-sulfur cluster assembly enzyme -2.11132
HPCAL1 hippocalcin-like 1 -2.10611
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -2.09593
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.07545
RFC2 replication factor C (activator 1) 2, 40kDa -2.03228
TRIM8 tripartite motif containing 8 -2.03098