CRCGN014_HEPG2_24H:F08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

318 genes differentially expressed following the CRCGN014_HEPG2_24H:F08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 7.86863
MYLK myosin light chain kinase 7.66919
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 7.4248
E2F2 E2F transcription factor 2 7.2402
C2CD2 C2 calcium-dependent domain containing 2 7.14893
CHMP6 charged multivesicular body protein 6 6.66022
CCL2 chemokine (C-C motif) ligand 2 6.06297
LYN LYN proto-oncogene, Src family tyrosine kinase 5.53874
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.48006
RPL39L ribosomal protein L39-like 5.4501
MSRA methionine sulfoxide reductase A 5.34813
EGF epidermal growth factor 5.26502
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.24956
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.17164
PNKP polynucleotide kinase 3'-phosphatase 5.14639
MAP7 microtubule-associated protein 7 5.10243
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.07546
ADRB2 adrenoceptor beta 2, surface 5.07497
CIAO3 cytosolic iron-sulfur assembly component 3 5.05821
AMDHD2 amidohydrolase domain containing 2 5.01308
H2BC21 H2B clustered histone 21 4.99932
GSTZ1 glutathione S-transferase zeta 1 4.93883
NOTCH1 notch 1 4.93523
CXCL2 chemokine (C-X-C motif) ligand 2 4.87427
KLHL21 kelch-like family member 21 4.87217
CARMIL1 capping protein regulator and myosin 1 linker 1 4.78863
PLS1 plastin 1 4.68346
HDGFL3 HDGF like 3 4.68104
PRAF2 PRA1 domain family, member 2 4.66383
MOK MOK protein kinase 4.36525
SNAP25 synaptosomal-associated protein, 25kDa 4.27615
CXCR4 chemokine (C-X-C motif) receptor 4 3.74772
CHN1 chimerin 1 3.73521
EPHA3 EPH receptor A3 3.67829
GATA3 GATA binding protein 3 3.52782
ABHD6 abhydrolase domain containing 6 3.44871
PPARG peroxisome proliferator-activated receptor gamma 3.36938
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.31853
KDM5A lysine (K)-specific demethylase 5A 3.30065
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.2522
DENND2D DENN/MADD domain containing 2D 3.21612
VGLL4 vestigial-like family member 4 3.2114
PEX11A peroxisomal biogenesis factor 11 alpha 3.19656
NOSIP nitric oxide synthase interacting protein 3.17262
PID1 phosphotyrosine interaction domain containing 1 3.08291
MICALL1 MICAL-like 1 3.06012
GSTM5 glutathione S-transferase mu 5 3.02562
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.91508
TBP TATA box binding protein 2.9094
ZNF528 zinc finger protein 528 2.8932
TBXA2R thromboxane A2 receptor 2.89263
BPHL biphenyl hydrolase-like (serine hydrolase) 2.87499
NINJ1 ninjurin 1 2.87167
DMTF1 cyclin D binding myb-like transcription factor 1 2.86487
EDA2R ectodysplasin A2 receptor 2.744
ZFP36 ZFP36 ring finger protein 2.69073
FBXO5 F-box protein 5 2.69053
AGRP agouti related neuropeptide 2.68107
RASL10A RAS-like, family 10, member A 2.65106
CT55 cancer/testis antigen 55 2.64419
TMEM47 transmembrane protein 47 2.63523
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.61375
FAM169A family with sequence similarity 169, member A 2.58596
SLC30A3 solute carrier family 30 (zinc transporter), member 3 2.57695
FZD7 frizzled class receptor 7 2.56591
GRM2 glutamate receptor, metabotropic 2 2.5607
GPR63 G protein-coupled receptor 63 2.55096
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.54572
TBX3 T-box 3 2.53822
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.52032
EDDM3A epididymal protein 3A 2.51802
NDP Norrie disease (pseudoglioma) 2.51219
SLC75A1 solute carrier family 75 member 1 2.49547
CRHBP corticotropin releasing hormone binding protein 2.48864
ADAM7 ADAM metallopeptidase domain 7 2.48741
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 2.46611
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 2.46521
ZNF236 zinc finger protein 236 2.46156
LSR lipolysis stimulated lipoprotein receptor 2.45705
TPD52L1 tumor protein D52-like 1 2.44605
DEFB126 defensin, beta 126 2.442
EDNRA endothelin receptor type A 2.43923
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2.43879
GALR3 galanin receptor 3 2.43261
TRIM5 tripartite motif containing 5 2.42965
PF4V1 platelet factor 4 variant 1 2.42785
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.42506
PDE5A phosphodiesterase 5A, cGMP-specific 2.40977
TESMIN testis expressed metallothionein like protein 2.40808
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.38437
FHL5 four and a half LIM domains 5 2.38398
ETAA1 Ewing tumor-associated antigen 1 2.37923
H2AC19 H2A clustered histone 19 2.37479
SOCS2 suppressor of cytokine signaling 2 2.36936
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.36814
ZNF589 zinc finger protein 589 2.36756
PCDHB11 protocadherin beta 11 2.36746
ZNF552 zinc finger protein 552 2.35554
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 2.35226
PDK3 pyruvate dehydrogenase kinase, isozyme 3 2.34824
DGKG diacylglycerol kinase, gamma 90kDa 2.34608
CRYBB1 crystallin, beta B1 2.3449
ZIM2 zinc finger, imprinted 2 2.33525
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 2.33442
WDR4 WD repeat domain 4 2.33416
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 2.32878
FAM204A family with sequence similarity 204, member A 2.32704
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 2.32244
MGAM maltase-glucoamylase 2.31904
LGI2 leucine-rich repeat LGI family, member 2 2.31245
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 2.31242
PHEX phosphate regulating endopeptidase homolog, X-linked 2.30571
FRK fyn-related Src family tyrosine kinase 2.30016
BRS3 bombesin-like receptor 3 2.29956
SKA1 spindle and kinetochore associated complex subunit 1 2.2962
CTPS2 CTP synthase 2 2.29121
GRWD1 glutamate-rich WD repeat containing 1 2.2849
STIMATE STIM activating enhancer 2.27769
TCTN2 tectonic family member 2 2.27647
MCF2 MCF.2 cell line derived transforming sequence 2.276
EDDM3B epididymal protein 3B 2.27105
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.27008
RLBP1 retinaldehyde binding protein 1 2.26678
PRRG3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) 2.26506
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 2.26323
IKZF2 IKAROS family zinc finger 2 (Helios) 2.26184
PKN1 protein kinase N1 2.25747
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 2.25718
CCNF cyclin F 2.25473
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 2.25336
TAC3 tachykinin 3 2.25234
ZNF215 zinc finger protein 215 2.25179
EPHB1 EPH receptor B1 2.23993
MAPK10 mitogen-activated protein kinase 10 2.23355
PPP4R3B protein phosphatase 4 regulatory subunit 3B 2.23056
BMP2 bone morphogenetic protein 2 2.22816
DCHS2 dachsous cadherin-related 2 2.22312
GPX5 glutathione peroxidase 5 2.22238
YAF2 YY1 associated factor 2 2.21537
SLC30A5 solute carrier family 30 (zinc transporter), member 5 2.20201
ALX4 ALX homeobox 4 2.20119
HNF4G hepatocyte nuclear factor 4, gamma 2.18733
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 2.17905
TMEM101 transmembrane protein 101 2.1776
MRPL30 mitochondrial ribosomal protein L30 2.1776
LUC7L LUC7-like (S. cerevisiae) 2.17541
TRIM49B tripartite motif containing 49B 2.17492
SOCS6 suppressor of cytokine signaling 6 2.17266
ELSPBP1 epididymal sperm binding protein 1 2.1695
ATP10D ATPase, class V, type 10D 2.16261
TMEM242 transmembrane protein 242 2.15762
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.15617
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) 2.15081
OR1D4 olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene) 2.13393
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 2.12875
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) 2.12641
DYNLT3 dynein, light chain, Tctex-type 3 2.12414
PPP4R4 protein phosphatase 4, regulatory subunit 4 2.12111
FFAR2 free fatty acid receptor 2 2.12083
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2.11829
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 2.11808
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 2.11523
MSTN myostatin 2.11316
CDH9 cadherin 9, type 2 (T1-cadherin) 2.10885
AVPR1B arginine vasopressin receptor 1B 2.10608
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.10486
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 2.10424
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 2.10371
TENT5A terminal nucleotidyltransferase 5A 2.10343
TOX3 TOX high mobility group box family member 3 2.10206
UNC5C unc-5 homolog C (C. elegans) 2.10001
PFDN6 prefoldin subunit 6 2.09998
MERTK MER proto-oncogene, tyrosine kinase 2.09948
PSG2 pregnancy specific beta-1-glycoprotein 2 2.09682
RORB RAR-related orphan receptor B 2.09553
COX11 COX11 cytochrome c oxidase copper chaperone 2.09499
PAX7 paired box 7 2.09353
SNCB synuclein, beta 2.09264
H2AB2 H2A.B variant histone 2 2.08652
TEC tec protein tyrosine kinase 2.08649
IMPACT impact RWD domain protein 2.08459
AQP4 aquaporin 4 2.08388
BBS7 Bardet-Biedl syndrome 7 2.08181
ITGA1 integrin, alpha 1 2.07741
PCDHGA10 protocadherin gamma subfamily A, 10 2.07511
HKDC1 hexokinase domain containing 1 2.07377
S100G S100 calcium binding protein G 2.07212
MAGEB4 melanoma antigen family B4 2.06738
KLF15 Kruppel-like factor 15 2.06097
DRP2 dystrophin related protein 2 2.06074
ZFP91 ZFP91 zinc finger protein 2.06046
LHFPL2 lipoma HMGIC fusion partner-like 2 2.05822
SMIM8 small integral membrane protein 8 2.05756
CD80 CD80 molecule 2.05743
CD300A CD300a molecule 2.05535
PTCD2 pentatricopeptide repeat domain 2 2.05477
USP22 ubiquitin specific peptidase 22 2.05381
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 2.05294
CEND1 cell cycle exit and neuronal differentiation 1 2.05181
CD244 CD244 molecule, natural killer cell receptor 2B4 2.04858
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 2.04828
FGF1 fibroblast growth factor 1 (acidic) 2.04795
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.04542
PPCDC phosphopantothenoylcysteine decarboxylase 2.04537
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.0451
SGMS1 sphingomyelin synthase 1 2.04126
HEYL hes-related family bHLH transcription factor with YRPW motif-like 2.0382
CNGA1 cyclic nucleotide gated channel alpha 1 2.03815
SLC16A4 solute carrier family 16, member 4 2.03812
IFT74 intraflagellar transport 74 2.03585
GOLGA6B golgin A6 family, member B 2.03521
MAGEA11 melanoma antigen family A11 2.03403
ADAM18 ADAM metallopeptidase domain 18 2.0336
FAM120C family with sequence similarity 120C 2.03346
ANGPT1 angiopoietin 1 2.02902
BCO1 beta-carotene oxygenase 1 2.02892
LUZP2 leucine zipper protein 2 2.02674
RXRG retinoid X receptor, gamma 2.02404
RBMS3 RNA binding motif, single stranded interacting protein 3 2.02348
IRGC immunity-related GTPase family, cinema 2.02263
GCM1 glial cells missing homolog 1 (Drosophila) 2.02171
EPB41L5 erythrocyte membrane protein band 4.1 like 5 2.01959
GMEB1 glucocorticoid modulatory element binding protein 1 2.01911
SCUBE2 signal peptide, CUB domain, EGF-like 2 2.01843
POU3F4 POU class 3 homeobox 4 2.01838
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.01828
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 2.01456
IL13RA2 interleukin 13 receptor, alpha 2 2.01289
RCC1 regulator of chromosome condensation 1 2.00954
ADPRH ADP-ribosylarginine hydrolase 2.0055
PRDM16 PR domain containing 16 2.00352
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 2.00231
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 2.00175
RIN2 Ras and Rab interactor 2 2.00068

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.35492
C2CD5 C2 calcium-dependent domain containing 5 -5.48154
MRPS2 mitochondrial ribosomal protein S2 -5.39417
ZDHHC6 zinc finger, DHHC-type containing 6 -5.30181
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.11555
VAT1 vesicle amine transport 1 -5.08128
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.04474
FABP5 fatty acid binding protein 5 (psoriasis-associated) -5.0
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.99004
LAP3 leucine aminopeptidase 3 -4.95917
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.91298
DUSP6 dual specificity phosphatase 6 -4.91215
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -4.87864
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.87354
COG7 component of oligomeric golgi complex 7 -4.86002
CDC20 cell division cycle 20 -4.8489
NT5DC2 5'-nucleotidase domain containing 2 -4.83345
TUBB6 tubulin, beta 6 class V -4.81005
KDM3A lysine (K)-specific demethylase 3A -4.73113
THAP11 THAP domain containing 11 -4.72767
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.62227
CHMP4B charged multivesicular body protein 4B -4.38273
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.34024
MAPK13 mitogen-activated protein kinase 13 -4.26048
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.22929
FBXL12 F-box and leucine-rich repeat protein 12 -4.1167
DCTD dCMP deaminase -3.97336
NCK1 NCK adaptor protein 1 -3.8745
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.8381
TRAPPC3 trafficking protein particle complex 3 -3.82448
ITGB1BP1 integrin beta 1 binding protein 1 -3.80957
TLCD3A TLC domain containing 3A -3.58222
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.44141
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.42312
NGRN neugrin, neurite outgrowth associated -3.37752
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.31172
YME1L1 YME1-like 1 ATPase -3.12788
ACAA1 acetyl-CoA acyltransferase 1 -3.08868
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.02513
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -3.01015
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.9824
GNAS GNAS complex locus -2.90401
TES testin LIM domain protein -2.84522
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.82345
IFRD2 interferon-related developmental regulator 2 -2.75988
HYOU1 hypoxia up-regulated 1 -2.64564
CEP170B centrosomal protein 170B -2.64455
ACP5 acid phosphatase 5, tartrate resistant -2.5873
CCNB2 cyclin B2 -2.58673
TMEM109 transmembrane protein 109 -2.44356
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 -2.42994
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -2.3809
ETHE1 ethylmalonic encephalopathy 1 -2.36659
SPATS2 spermatogenesis associated, serine-rich 2 -2.31336
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase -2.30482
HMG20B high mobility group 20B -2.3022
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.29773
ADIPOR1 adiponectin receptor 1 -2.29049
UBE3C ubiquitin protein ligase E3C -2.28028
TEAD3 TEA domain family member 3 -2.27743
RNF187 ring finger protein 187 -2.26099
TRIB2 tribbles pseudokinase 2 -2.25536
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -2.25344
TTC19 tetratricopeptide repeat domain 19 -2.21061
UBB ubiquitin B -2.20773
IFT52 intraflagellar transport 52 -2.20142
CFAP20 cilia and flagella associated protein 20 -2.19136
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.19125
PCNA proliferating cell nuclear antigen -2.18779
CTDNEP1 CTD nuclear envelope phosphatase 1 -2.18158
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 -2.17851
IL10RB interleukin 10 receptor, beta -2.17728
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -2.15807
MRPS15 mitochondrial ribosomal protein S15 -2.15739
POGLUT1 protein O-glucosyltransferase 1 -2.14408
RANBP10 RAN binding protein 10 -2.10531
EPHB4 EPH receptor B4 -2.10418
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.09688
ZNF74 zinc finger protein 74 -2.09182
COL8A2 collagen, type VIII, alpha 2 -2.08463
STAT1 signal transducer and activator of transcription 1, 91kDa -2.06917
TTI1 TELO2 interacting protein 1 -2.0624
FLCN folliculin -2.04328
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.01538