CRCGN014_HEPG2_24H:F09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclohexanone 41.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN014_HEPG2_24H:F09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 6.83414
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.54183
CIAO3 cytosolic iron-sulfur assembly component 3 5.2348
MYLK myosin light chain kinase 4.97963
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.94022
CARMIL1 capping protein regulator and myosin 1 linker 1 4.75399
AMDHD2 amidohydrolase domain containing 2 4.67171
C2CD2 C2 calcium-dependent domain containing 2 4.56042
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.41902
PLS1 plastin 1 3.6567
GATA3 GATA binding protein 3 3.20684
LOC122526780 uncharacterized LOC122526780 3.03387
EPHA3 EPH receptor A3 2.87769
PRR15L proline rich 15-like 2.87436
DIPK1A divergent protein kinase domain 1A 2.76864
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.60599
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.55657
CHN1 chimerin 1 2.50788
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.45276
C4A complement component 4A (Rodgers blood group) 2.25991
EVL Enah/Vasp-like 2.2219
KLHL1 kelch-like family member 1 2.19896
TMEM268 transmembrane protein 268 2.12996
NUP93 nucleoporin 93kDa 2.1254
PKD2L1 polycystic kidney disease 2-like 1 2.09943
BIRC2 baculoviral IAP repeat containing 2 2.09445
CEMIP2 cell migration inducing hyaluronidase 2 2.08505
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.05734

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.71603
VAT1 vesicle amine transport 1 -5.17112
LDHD lactate dehydrogenase D -4.99886
CDC20 cell division cycle 20 -4.90991
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.90814
PLK1 polo-like kinase 1 -4.83414
CCNB1 cyclin B1 -4.43701
MAPK13 mitogen-activated protein kinase 13 -3.97213
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.55103
PEG10 paternally expressed 10 -3.22888
GNAS GNAS complex locus -3.144
HMG20B high mobility group 20B -3.0176
NVL nuclear VCP-like -2.56607
PCNA proliferating cell nuclear antigen -2.40241
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -2.21958
PORCN porcupine homolog (Drosophila) -2.16324
EIF5 eukaryotic translation initiation factor 5 -2.14466
UBE2S ubiquitin-conjugating enzyme E2S -2.13137
ADI1 acireductone dioxygenase 1 -2.07828
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.07556