CRCGN014_HEPG2_24H:F10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methyl (z)-2-(dimethylamino)-n-((methylcarbamoyl)oxy)-2-oxoethanimidothioate 20.07 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

23 genes differentially expressed following the CRCGN014_HEPG2_24H:F10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 5.40075
CHMP6 charged multivesicular body protein 6 4.21875
CXCL2 chemokine (C-X-C motif) ligand 2 4.08362
C2CD2 C2 calcium-dependent domain containing 2 3.25526
KDM5A lysine (K)-specific demethylase 5A 3.04096
HACD2 3-hydroxyacyl-CoA dehydratase 2 2.33877
TREM1 triggering receptor expressed on myeloid cells 1 2.3209
DIPK1A divergent protein kinase domain 1A 2.25913
SFTPB surfactant protein B 2.25724
RPL29 ribosomal protein L29 2.1415
PIH1D1 PIH1 domain containing 1 2.0941
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.03748

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -8.72261
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.87544
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.12501
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.63148
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.46364
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.91284
TRAPPC3 trafficking protein particle complex 3 -2.85153
EIF5 eukaryotic translation initiation factor 5 -2.78678
OXA1L oxidase (cytochrome c) assembly 1-like -2.64526
RAI14 retinoic acid induced 14 -2.55635
ZNF586 zinc finger protein 586 -2.25509