CRCGN014_HEPG2_24H:F16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4,6-trimethylaniline 20.07 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN014_HEPG2_24H:F16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 8.50312
E2F2 E2F transcription factor 2 4.3792
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.07195
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.7728
MAP7 microtubule-associated protein 7 3.22526
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.09077
TIAM1 T-cell lymphoma invasion and metastasis 1 2.86048
TREM1 triggering receptor expressed on myeloid cells 1 2.6741
HEBP1 heme binding protein 1 2.45816
PLSCR1 phospholipid scramblase 1 2.42967
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.18167
FAIM Fas apoptotic inhibitory molecule 2.18153
ZFP36 ZFP36 ring finger protein 2.08609
GPER1 G protein-coupled estrogen receptor 1 2.03914
MAMLD1 mastermind-like domain containing 1 2.03258

decreased expression

Symbol Name Standardized Value
UGDH UDP-glucose 6-dehydrogenase -4.3143
SCAND1 SCAN domain containing 1 -4.15931
CDC20 cell division cycle 20 -4.01534
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.75091
TLR4 toll-like receptor 4 -3.66213
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -3.63897
TXNRD1 thioredoxin reductase 1 -3.11187
MAPK13 mitogen-activated protein kinase 13 -2.85943
GDF15 growth differentiation factor 15 -2.70186
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.58614
DNM1L dynamin 1-like -2.525
LOC124907782 dual specificity protein phosphatase 22 -2.17815
RGS2 regulator of G-protein signaling 2 -2.10565
OXA1L oxidase (cytochrome c) assembly 1-like -2.03546