CRCGN014_HEPG2_24H:F18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(2-bromo-2-ethylbutanoyl)urea 20.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

124 genes differentially expressed following the CRCGN014_HEPG2_24H:F18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EPHB2 EPH receptor B2 7.08702
NOTCH1 notch 1 6.85202
STIMATE STIM activating enhancer 5.62316
MAP7 microtubule-associated protein 7 5.54215
MYLK myosin light chain kinase 5.17744
CIAO3 cytosolic iron-sulfur assembly component 3 4.98541
EVL Enah/Vasp-like 4.10466
PLSCR1 phospholipid scramblase 1 3.88661
CRIPTO3 cripto, EGF-CFC family member 3 3.3249
DPEP1 dipeptidase 1 (renal) 3.26272
GSTZ1 glutathione S-transferase zeta 1 3.12344
TIAM1 T-cell lymphoma invasion and metastasis 1 3.09827
DEFA6 defensin, alpha 6, Paneth cell-specific 3.02487
EPHB3 EPH receptor B3 3.02388
LPAR2 lysophosphatidic acid receptor 2 3.00609
GPHN gephyrin 2.7904
CDX1 caudal type homeobox 1 2.73766
NPDC1 neural proliferation, differentiation and control, 1 2.73607
CXCL2 chemokine (C-X-C motif) ligand 2 2.67327
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.64095
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.5818
ZBTB7B zinc finger and BTB domain containing 7B 2.5757
VAV3 vav 3 guanine nucleotide exchange factor 2.51885
ABHD6 abhydrolase domain containing 6 2.5178
OVOL3 ovo-like zinc finger 3 2.51207
DEFA5 defensin, alpha 5, Paneth cell-specific 2.47152
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.43415
PMFBP1 polyamine modulated factor 1 binding protein 1 2.42599
CCL24 chemokine (C-C motif) ligand 24 2.42197
CDPF1 cysteine-rich, DPF motif domain containing 1 2.41316
AMDHD2 amidohydrolase domain containing 2 2.41236
KCTD11 potassium channel tetramerization domain containing 11 2.40434
RPL39L ribosomal protein L39-like 2.38941
L1TD1 LINE-1 type transposase domain containing 1 2.36828
NOX1 NADPH oxidase 1 2.33662
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.3264
ADGRB1 adhesion G protein-coupled receptor B1 2.31482
LCN2 lipocalin 2 2.3127
GPATCH8 G patch domain containing 8 2.30966
CLCA1 chloride channel accessory 1 2.3081
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 2.30683
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.30663
LY6G6F-LY6G6D LY6G6F-LY6G6D readthrough 2.29386
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.29083
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.26847
GJC2 gap junction protein, gamma 2, 47kDa 2.26593
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 2.26148
AMHR2 anti-Mullerian hormone receptor, type II 2.25884
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 2.24646
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.24622
TRIM25 tripartite motif containing 25 2.24203
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.23691
TREML2 triggering receptor expressed on myeloid cells-like 2 2.2123
REG3A regenerating islet-derived 3 alpha 2.2106
PCDHGA3 protocadherin gamma subfamily A, 3 2.20371
DOT1L DOT1-like histone H3K79 methyltransferase 2.19847
GUCY2C guanylate cyclase 2C 2.19805
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 2.19518
KLK15 kallikrein-related peptidase 15 2.1768
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.16775
HOXB9 homeobox B9 2.15877
KANSL3 KAT8 regulatory NSL complex subunit 3 2.15677
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.1484
GPSM2 G-protein signaling modulator 2 2.1417
SAMD4B sterile alpha motif domain containing 4B 2.14116
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 2.13044
WNT11 wingless-type MMTV integration site family, member 11 2.12023
HEYL hes-related family bHLH transcription factor with YRPW motif-like 2.1189
FGF18 fibroblast growth factor 18 2.11776
TEX28 testis expressed 28 2.11567
SHH sonic hedgehog 2.10339
ASCL2 achaete-scute family bHLH transcription factor 2 2.10171
ELL elongation factor RNA polymerase II 2.09818
GADD45G growth arrest and DNA-damage-inducible, gamma 2.09635
GCGR glucagon receptor 2.07528
VWA7 von Willebrand factor A domain containing 7 2.07451
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 2.07297
CAMK1D calcium/calmodulin-dependent protein kinase ID 2.07224
NOSIP nitric oxide synthase interacting protein 2.07103
WDR18 WD repeat domain 18 2.04919
TLX1 T-cell leukemia homeobox 1 2.04746
GDF9 growth differentiation factor 9 2.04583
ZNF428 zinc finger protein 428 2.03923
TTPA tocopherol (alpha) transfer protein 2.03459
LAGE3 L antigen family, member 3 2.02657
RAB40C RAB40C, member RAS oncogene family 2.02207
ADH6 alcohol dehydrogenase 6 (class V) 2.01669
SBNO2 strawberry notch homolog 2 (Drosophila) 2.01429
NHLH1 nescient helix loop helix 1 2.01127
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 2.00989
DOK3 docking protein 3 2.00722
MED16 mediator complex subunit 16 2.00523
SCTR secretin receptor 2.00222

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -7.4993
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -7.37221
LDHD lactate dehydrogenase D -7.3042
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.0782
ACOT9 acyl-CoA thioesterase 9 -4.92401
TUBB6 tubulin, beta 6 class V -4.85456
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.79271
FASTKD5 FAST kinase domains 5 -4.69948
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -4.53074
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.01824
OXA1L oxidase (cytochrome c) assembly 1-like -3.96067
ZW10 zw10 kinetochore protein -3.32194
PEG10 paternally expressed 10 -3.2413
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.10931
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.89574
FBXL12 F-box and leucine-rich repeat protein 12 -2.7295
DNM1L dynamin 1-like -2.66955
PRPF4 pre-mRNA processing factor 4 -2.66922
TRIB3 tribbles pseudokinase 3 -2.51707
GSDME gasdermin E -2.4729
NVL nuclear VCP-like -2.47051
FKBP1B FK506 binding protein 1B, 12.6 kDa -2.42319
ICAM3 intercellular adhesion molecule 3 -2.40222
SNX11 sorting nexin 11 -2.3002
SPAG4 sperm associated antigen 4 -2.2832
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 -2.1242
RPIA ribose 5-phosphate isomerase A -2.10023
GTPBP8 GTP-binding protein 8 (putative) -2.09301
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.08198
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -2.02262
STX4 syntaxin 4 -2.00914