| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | spironolactone 20.64 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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66 genes differentially expressed following the CRCGN014_HEPG2_24H:F20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF589 | zinc finger protein 589 | 5.7238 |
| H2BC12 | H2B clustered histone 12 | 4.45144 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 4.21013 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 3.5776 |
| BIRC2 | baculoviral IAP repeat containing 2 | 3.4845 |
| EPHB2 | EPH receptor B2 | 3.44892 |
| TMEM50A | transmembrane protein 50A | 3.36844 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.29526 |
| NMU | neuromedin U | 3.06007 |
| CHN1 | chimerin 1 | 3.02894 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 2.95746 |
| STK10 | serine/threonine kinase 10 | 2.91269 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.89885 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.89756 |
| CHMP6 | charged multivesicular body protein 6 | 2.78256 |
| VGLL4 | vestigial-like family member 4 | 2.7692 |
| ECD | ecdysoneless homolog (Drosophila) | 2.76838 |
| CCDC92 | coiled-coil domain containing 92 | 2.69803 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 2.68669 |
| ABHD6 | abhydrolase domain containing 6 | 2.622 |
| DSG2 | desmoglein 2 | 2.46445 |
| PCSK7 | proprotein convertase subtilisin/kexin type 7 | 2.46015 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 2.44095 |
| EMC3 | ER membrane protein complex subunit 3 | 2.42237 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 2.37602 |
| DEAF1 | DEAF1 transcription factor | 2.37522 |
| SIRT3 | sirtuin 3 | 2.32475 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | 2.26927 |
| MBIP | MAP3K12 binding inhibitory protein 1 | 2.07975 |
| TESK1 | testis-specific kinase 1 | 2.07365 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | 2.06483 |
| H2BC21 | H2B clustered histone 21 | 2.01488 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -9.80031 |
| FGFR4 | fibroblast growth factor receptor 4 | -5.06797 |
| PCNA | proliferating cell nuclear antigen | -4.7492 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -4.62241 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -4.15237 |
| PLK1 | polo-like kinase 1 | -4.14575 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -3.7122 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.70826 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -3.5157 |
| KDM3A | lysine (K)-specific demethylase 3A | -3.34312 |
| GOLT1B | golgi transport 1B | -3.29887 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.18618 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | -3.17131 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | -3.09477 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.08177 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -2.96941 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -2.94644 |
| DNM1L | dynamin 1-like | -2.90375 |
| ZNF586 | zinc finger protein 586 | -2.88065 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -2.79872 |
| TLR4 | toll-like receptor 4 | -2.78902 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -2.57067 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -2.49166 |
| WASHC4 | WASH complex subunit 4 | -2.45675 |
| SPAG7 | sperm associated antigen 7 | -2.35094 |
| RPS5 | ribosomal protein S5 | -2.27632 |
| EGF | epidermal growth factor | -2.19845 |
| HMG20B | high mobility group 20B | -2.1798 |
| UNG | uracil-DNA glycosylase | -2.17779 |
| CCNB2 | cyclin B2 | -2.10859 |
| NBPF19 | neuroblastoma breakpoint family, member 19 | -2.03857 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -2.02899 |
| NGRN | neugrin, neurite outgrowth associated | -2.01235 |
| FUT5 | fucosyltransferase 5 (alpha (1,3) fucosyltransferase) | -2.0018 |
