CRCGN014_HEPG2_24H:F23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description monochloroacetic acid 38.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

97 genes differentially expressed following the CRCGN014_HEPG2_24H:F23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KLHL21 kelch-like family member 21 5.45177
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.77739
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.49928
UBQLN2 ubiquilin 2 4.2267
VGLL4 vestigial-like family member 4 4.21826
CAPN1 calpain 1, (mu/I) large subunit 4.13706
MOK MOK protein kinase 4.03895
MAMLD1 mastermind-like domain containing 1 4.03711
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.99622
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.95199
HLA-DMA major histocompatibility complex, class II, DM alpha 3.94405
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.94175
EPHA3 EPH receptor A3 3.91185
ADGRE5 adhesion G protein-coupled receptor E5 3.70601
HOXA10 homeobox A10 3.64998
MEF2C myocyte enhancer factor 2C 3.44781
DENND2D DENN/MADD domain containing 2D 3.32349
AMDHD2 amidohydrolase domain containing 2 3.17906
KDM5A lysine (K)-specific demethylase 5A 3.0374
NMU neuromedin U 2.86998
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.79795
SATB1 SATB homeobox 1 2.71156
AHR aryl hydrocarbon receptor 2.68925
CXCL2 chemokine (C-X-C motif) ligand 2 2.67518
ABHD6 abhydrolase domain containing 6 2.62541
HEBP1 heme binding protein 1 2.57618
PRKCH protein kinase C, eta 2.46874
PRR15L proline rich 15-like 2.44357
EPHA4 EPH receptor A4 2.43527
JADE2 jade family PHD finger 2 2.42422
LOC122526780 uncharacterized LOC122526780 2.38927
ARID4A AT rich interactive domain 4A (RBP1-like) 2.37156
DGKI diacylglycerol kinase, iota 2.369
CCN3 cellular communication network factor 3 2.3534
ENTREP1 endosomal transmembrane epsin interactor 1 2.32685
COL6A3 collagen, type VI, alpha 3 2.29337
NUP133 nucleoporin 133kDa 2.26571
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.23604
PPARG peroxisome proliferator-activated receptor gamma 2.17633
TSHR thyroid stimulating hormone receptor 2.17582
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.16579
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.14355
FZD7 frizzled class receptor 7 2.14274
ARMCX5 armadillo repeat containing, X-linked 5 2.13079
DMTF1 cyclin D binding myb-like transcription factor 1 2.12335
OSBPL7 oxysterol binding protein-like 7 2.11486
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.10114
RBM12B RNA binding motif protein 12B 2.08998
PLGLB2 plasminogen-like B2 2.08592
MAP7 microtubule-associated protein 7 2.07637
BPHL biphenyl hydrolase-like (serine hydrolase) 2.03536
PCDHB11 protocadherin beta 11 2.03174
PCDHGA10 protocadherin gamma subfamily A, 10 2.0191
ZNF589 zinc finger protein 589 2.00754
CHN1 chimerin 1 2.0004

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.80909
MAPK13 mitogen-activated protein kinase 13 -5.03925
ZNF586 zinc finger protein 586 -4.82691
FGFR4 fibroblast growth factor receptor 4 -4.49147
PCCB propionyl CoA carboxylase, beta polypeptide -4.21911
ZDHHC6 zinc finger, DHHC-type containing 6 -4.16306
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.13233
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.04936
DSG2 desmoglein 2 -3.97279
CDC20 cell division cycle 20 -3.90432
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.89442
CCDC86 coiled-coil domain containing 86 -3.8916
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.51503
NT5DC2 5'-nucleotidase domain containing 2 -3.48269
TM9SF3 transmembrane 9 superfamily member 3 -3.46081
GADD45A growth arrest and DNA-damage-inducible, alpha -3.35353
JMJD6 jumonji domain containing 6 -3.28907
NGRN neugrin, neurite outgrowth associated -3.23132
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.07041
DERA deoxyribose-phosphate aldolase (putative) -3.04768
CHMP4B charged multivesicular body protein 4B -2.96981
NRIP1 nuclear receptor interacting protein 1 -2.88901
FASTKD5 FAST kinase domains 5 -2.81857
YME1L1 YME1-like 1 ATPase -2.77658
LYPLA1 lysophospholipase I -2.7567
PEG10 paternally expressed 10 -2.73721
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.73244
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.69111
RFC2 replication factor C (activator 1) 2, 40kDa -2.65231
HEATR1 HEAT repeat containing 1 -2.53243
CCNB2 cyclin B2 -2.41936
SLC35F2 solute carrier family 35, member F2 -2.39299
PDHX pyruvate dehydrogenase complex, component X -2.33166
GNAS GNAS complex locus -2.30876
STX4 syntaxin 4 -2.25195
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.16847
SMAD7 SMAD family member 7 -2.16424
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.16423
EGF epidermal growth factor -2.15932
NAT10 N-acetyltransferase 10 (GCN5-related) -2.09208
PCSK7 proprotein convertase subtilisin/kexin type 7 -2.06896
GRPEL1 GrpE-like 1, mitochondrial (E. coli) -2.03924