CRCGN014_HEPG2_24H:F24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description theophylline 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

91 genes differentially expressed following the CRCGN014_HEPG2_24H:F24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 7.20213
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.89723
ADRB2 adrenoceptor beta 2, surface 6.74668
HOXA10 homeobox A10 5.51924
ABHD6 abhydrolase domain containing 6 4.86864
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 4.51355
DYNLT3 dynein, light chain, Tctex-type 3 4.22016
MAP7 microtubule-associated protein 7 4.19544
GPER1 G protein-coupled estrogen receptor 1 4.18195
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.97316
CHN1 chimerin 1 3.33888
TATDN2 TatD DNase domain containing 2 3.31969
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.29007
SYNE2 spectrin repeat containing, nuclear envelope 2 3.22555
MSRA methionine sulfoxide reductase A 3.12723
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.05212
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 3.04549
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.92197
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.90081
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.80796
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.77393
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.77217
ANO1 anoctamin 1, calcium activated chloride channel 2.76349
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.74875
ADGRE5 adhesion G protein-coupled receptor E5 2.6257
BZW2 basic leucine zipper and W2 domains 2 2.61364
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.59275
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.49688
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.44143
PNKP polynucleotide kinase 3'-phosphatase 2.43252
SFTPB surfactant protein B 2.34129
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.30745
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.25815
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.25577
CYCS cytochrome c, somatic 2.25515
AMDHD2 amidohydrolase domain containing 2 2.24979
NOTCH1 notch 1 2.23184
CARMIL1 capping protein regulator and myosin 1 linker 1 2.22771
KIF5C kinesin family member 5C 2.21845
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.21679
STK10 serine/threonine kinase 10 2.20942
CLSTN2 calsyntenin 2 2.18672
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.12545
CCNA1 cyclin A1 2.1202
E2F2 E2F transcription factor 2 2.09676
PPARG peroxisome proliferator-activated receptor gamma 2.09526
CHMP6 charged multivesicular body protein 6 2.05499
ATP11B ATPase, class VI, type 11B 2.05057
NOSIP nitric oxide synthase interacting protein 2.03792
CD40 CD40 molecule, TNF receptor superfamily member 5 2.00241

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.11566
ZNF586 zinc finger protein 586 -5.46626
COG2 component of oligomeric golgi complex 2 -4.70826
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.96369
LDHD lactate dehydrogenase D -3.93275
PLK1 polo-like kinase 1 -3.75119
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.59345
GOLT1B golgi transport 1B -3.42603
TLR4 toll-like receptor 4 -3.282
PCCB propionyl CoA carboxylase, beta polypeptide -3.12895
OXA1L oxidase (cytochrome c) assembly 1-like -3.11749
TWF2 twinfilin actin binding protein 2 -3.11196
GTPBP8 GTP-binding protein 8 (putative) -3.02356
FGFR4 fibroblast growth factor receptor 4 -3.00245
C2CD5 C2 calcium-dependent domain containing 5 -2.98997
HAT1 histone acetyltransferase 1 -2.93635
TRIB3 tribbles pseudokinase 3 -2.92921
UGDH UDP-glucose 6-dehydrogenase -2.89047
DUSP6 dual specificity phosphatase 6 -2.87947
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.86804
GDF15 growth differentiation factor 15 -2.76349
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.72833
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.72081
ZDHHC6 zinc finger, DHHC-type containing 6 -2.6974
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.64066
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.55801
RPIA ribose 5-phosphate isomerase A -2.43008
DERA deoxyribose-phosphate aldolase (putative) -2.36249
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.2758
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.25491
CDC20 cell division cycle 20 -2.25395
FASTKD5 FAST kinase domains 5 -2.24449
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.20289
LYPLA1 lysophospholipase I -2.11414
VCAN versican -2.10958
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.10292
THAP11 THAP domain containing 11 -2.09922
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.09181
FAIM Fas apoptotic inhibitory molecule -2.0873
CCDC86 coiled-coil domain containing 86 -2.05936
CRELD2 cysteine-rich with EGF-like domains 2 -2.04209