CRCGN014_HEPG2_24H:G01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description furfural 38.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

137 genes differentially expressed following the CRCGN014_HEPG2_24H:G01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 9.73679
CXCL2 chemokine (C-X-C motif) ligand 2 7.30547
KCNK1 potassium channel, two pore domain subfamily K, member 1 6.55186
CHMP6 charged multivesicular body protein 6 5.95876
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.70157
MAMLD1 mastermind-like domain containing 1 5.22584
EVL Enah/Vasp-like 4.47056
INTS3 integrator complex subunit 3 4.0873
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 3.92295
RPP38 ribonuclease P/MRP 38kDa subunit 3.89681
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.8693
CBR3 carbonyl reductase 3 3.86783
PNKP polynucleotide kinase 3'-phosphatase 3.8446
UBQLN2 ubiquilin 2 3.83057
BZW2 basic leucine zipper and W2 domains 2 3.77536
ADGRE5 adhesion G protein-coupled receptor E5 3.76686
LSR lipolysis stimulated lipoprotein receptor 3.75731
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.73268
MOK MOK protein kinase 3.55658
NOSIP nitric oxide synthase interacting protein 3.54697
SFTPB surfactant protein B 3.2587
DIPK1A divergent protein kinase domain 1A 2.9954
ZNF589 zinc finger protein 589 2.94266
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 2.87747
PEX11A peroxisomal biogenesis factor 11 alpha 2.87692
CXCR4 chemokine (C-X-C motif) receptor 4 2.87341
MTERF3 mitochondrial transcription termination factor 3 2.77421
ABHD6 abhydrolase domain containing 6 2.73187
PPARG peroxisome proliferator-activated receptor gamma 2.7112
PLSCR3 phospholipid scramblase 3 2.66361
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.60163
ZNF232 zinc finger protein 232 2.58019
MTA2 metastasis associated 1 family, member 2 2.57675
TIAM1 T-cell lymphoma invasion and metastasis 1 2.56002
FAM114A1 family with sequence similarity 114, member A1 2.49419
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 2.4891
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.46619
SNX17 sorting nexin 17 2.4335
PRKX protein kinase, X-linked 2.39979
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.39827
EPHB2 EPH receptor B2 2.36979
JMJD4 jumonji domain containing 4 2.3661
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 2.36165
MNMIP1 manchette microtubule inner protein 1 2.33497
CHEK2 checkpoint kinase 2 2.32635
TUBG1 tubulin, gamma 1 2.3181
TMEM187 transmembrane protein 187 2.27286
PTOV1 prostate tumor overexpressed 1 2.26989
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.26413
ZBTB32 zinc finger and BTB domain containing 32 2.26093
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 2.25735
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 2.24507
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 2.22248
NUP133 nucleoporin 133kDa 2.2179
CNGA1 cyclic nucleotide gated channel alpha 1 2.18483
MICALL1 MICAL-like 1 2.17889
PORCN porcupine homolog (Drosophila) 2.16807
SATB1 SATB homeobox 1 2.15831
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 2.15505
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 2.14407
KDM1A lysine (K)-specific demethylase 1A 2.13807
AGBL2 ATP/GTP binding protein-like 2 2.12592
KRT76 keratin 76, type II 2.10297
ERO1B endoplasmic reticulum oxidoreductase 1 beta 2.09613
SUZ12 SUZ12 polycomb repressive complex 2 subunit 2.08064
RPA3 replication protein A3, 14kDa 2.07679
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.07664
BRD9 bromodomain containing 9 2.07591
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.06082
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 2.04946
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.04507
GMPPA GDP-mannose pyrophosphorylase A 2.03851
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.02973
CDK19 cyclin-dependent kinase 19 2.02592
PRM2 protamine 2 2.02257
ZBTB25 zinc finger and BTB domain containing 25 2.0146
MBNL3 muscleblind-like splicing regulator 3 2.0094

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -8.92065
LDHD lactate dehydrogenase D -8.83219
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -6.0581
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.35371
TLR4 toll-like receptor 4 -5.19599
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.58156
CCNB2 cyclin B2 -4.51015
RPS4Y1 ribosomal protein S4, Y-linked 1 -4.30196
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.2224
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.21014
KDM3A lysine (K)-specific demethylase 3A -4.20414
GTPBP8 GTP-binding protein 8 (putative) -4.12643
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.95927
CDC20 cell division cycle 20 -3.88671
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.83797
MRPS2 mitochondrial ribosomal protein S2 -3.81991
THAP11 THAP domain containing 11 -3.74382
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.71931
DNM1L dynamin 1-like -3.63658
C2CD5 C2 calcium-dependent domain containing 5 -3.59617
CHMP4B charged multivesicular body protein 4B -3.57157
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.55661
NCK1 NCK adaptor protein 1 -3.51643
ZNF146 zinc finger protein 146 -3.4043
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.33502
ZNF586 zinc finger protein 586 -3.30972
TSPAN4 tetraspanin 4 -3.28948
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.18821
TRIB3 tribbles pseudokinase 3 -3.15602
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.90564
DERA deoxyribose-phosphate aldolase (putative) -2.79907
ANKRD40 ankyrin repeat domain 40 -2.77586
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 -2.705
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.49233
PTPRK protein tyrosine phosphatase, receptor type, K -2.41783
CTSD cathepsin D -2.40492
H2BC5 H2B clustered histone 5 -2.38982
HDAC9 histone deacetylase 9 -2.38885
NOX4 NADPH oxidase 4 -2.38479
DOCK2 dedicator of cytokinesis 2 -2.32935
MOAP1 modulator of apoptosis 1 -2.29899
CD320 CD320 molecule -2.28536
CREBL2 cAMP responsive element binding protein-like 2 -2.27885
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.27618
ZNF274 zinc finger protein 274 -2.26566
SPAG16 sperm associated antigen 16 -2.25646
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) -2.25568
DSG2 desmoglein 2 -2.24883
CRELD2 cysteine-rich with EGF-like domains 2 -2.23244
SYNGR3 synaptogyrin 3 -2.23087
UNC13A unc-13 homolog A (C. elegans) -2.21349
ILK integrin-linked kinase -2.20448
FGFR4 fibroblast growth factor receptor 4 -2.19374
PILRB paired immunoglobin-like type 2 receptor beta -2.18639
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.14414
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.13039
NR1H2 nuclear receptor subfamily 1, group H, member 2 -2.12756
ARHGAP8 Rho GTPase activating protein 8 -2.11378
S100A14 S100 calcium binding protein A14 -2.02329
FOS FBJ murine osteosarcoma viral oncogene homolog -2.01745