CRCGN014_HEPG2_24H:G04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-aminoanthraquinone 39.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

73 genes differentially expressed following the CRCGN014_HEPG2_24H:G04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.90633
RPL39L ribosomal protein L39-like 3.90361
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.90253
PHKG2 phosphorylase kinase, gamma 2 (testis) 3.8505
CHN1 chimerin 1 3.7199
SFTPB surfactant protein B 3.67261
EGF epidermal growth factor 3.61333
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.41936
CCL2 chemokine (C-C motif) ligand 2 3.38239
UBQLN2 ubiquilin 2 3.28853
RPP38 ribonuclease P/MRP 38kDa subunit 3.21335
LCN2 lipocalin 2 3.09335
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.07833
ABHD6 abhydrolase domain containing 6 2.83887
PFKL phosphofructokinase, liver 2.72125
PMM2 phosphomannomutase 2 2.646
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.58145
TXNL4B thioredoxin-like 4B 2.5574
CCNF cyclin F 2.55571
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.53954
PTK7 protein tyrosine kinase 7 (inactive) 2.52671
FZD7 frizzled class receptor 7 2.50176
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.40304
GSTZ1 glutathione S-transferase zeta 1 2.38945
GATD3 glutamine amidotransferase class 1 domain containing 3 2.37401
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.30218
TNS3 tensin 3 2.14776
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.13825
GPER1 G protein-coupled estrogen receptor 1 2.08326
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.06695
JADE2 jade family PHD finger 2 2.02848
INPPL1 inositol polyphosphate phosphatase-like 1 2.0042
SREBF1 sterol regulatory element binding transcription factor 1 2.00339

decreased expression

Symbol Name Standardized Value
LAP3 leucine aminopeptidase 3 -6.99608
PCNA proliferating cell nuclear antigen -6.57721
UGDH UDP-glucose 6-dehydrogenase -6.18885
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.12244
COG2 component of oligomeric golgi complex 2 -5.87846
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.24185
ADI1 acireductone dioxygenase 1 -4.8156
DNM1L dynamin 1-like -3.67958
DSG2 desmoglein 2 -3.53979
NT5DC2 5'-nucleotidase domain containing 2 -3.51831
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.4811
ZDHHC6 zinc finger, DHHC-type containing 6 -3.45624
NRIP1 nuclear receptor interacting protein 1 -3.42725
GOLT1B golgi transport 1B -3.4256
MRPS2 mitochondrial ribosomal protein S2 -3.36455
GDF15 growth differentiation factor 15 -3.36115
CDC20 cell division cycle 20 -3.34863
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.34709
KDM3A lysine (K)-specific demethylase 3A -3.26813
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.23249
THAP11 THAP domain containing 11 -3.23005
SOAT2 sterol O-acyltransferase 2 -3.04718
CCDC86 coiled-coil domain containing 86 -3.01337
CHMP4B charged multivesicular body protein 4B -2.99338
TRIB3 tribbles pseudokinase 3 -2.9695
ZNF586 zinc finger protein 586 -2.91924
LDHD lactate dehydrogenase D -2.91638
ALDOC aldolase C, fructose-bisphosphate -2.81377
CD320 CD320 molecule -2.80102
RPIA ribose 5-phosphate isomerase A -2.60662
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.46669
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.46029
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.45414
TCTN1 tectonic family member 1 -2.42121
CHIC2 cysteine-rich hydrophobic domain 2 -2.21326
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.2062
GNAS GNAS complex locus -2.07375
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.06081
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -2.01971
LOC128966601 pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial-like -2.01757